Lights, camera, actin! The cytoskeleton takes center stage in mechanotransduction. Focus on "Mapping the dynamics of shear stress-induced structural changes in endothelial cells"

American Journal of Physiology - Cell Physiology

Volumn 293, Issue 6, 2007, Pages

  Rizzo, Victor ^a  

^a TEMPLE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACTIN; CD31 ANTIGEN; FOCAL ADHESION KINASE; G PROTEIN COUPLED RECEPTOR; INTEGRIN; RHOA GUANINE NUCLEOTIDE BINDING PROTEIN;

ACTIN POLYMERIZATION; CELL ADHESION; CELL JUNCTION; EDITORIAL; ENDOTHELIUM CELL; EXTRACELLULAR MATRIX; HUMAN; MECHANOTRANSDUCTION; NONHUMAN; PRIORITY JOURNAL; SHEAR STRESS;

ACTINS; ANIMALS; CYTOSKELETON; ENDOTHELIAL CELLS; EXTRACELLULAR MATRIX; FOCAL ADHESIONS; MECHANOTRANSDUCTION, CELLULAR; STRESS, MECHANICAL;

EID: 37149019967     PISSN: 03636143     EISSN: 15221563     Source Type: Journal    
DOI: 10.1152/ajpcell.00453.2007     Document Type: Editorial

References (14)

1. Chien S. Molecular and mechanical bases of focal lipid accumulation in arterial wall. Prog Biophys Mol Biol 83: 131, 2003.
2. Cunningham K, Gotlieb A. The role of shear stress in the pathogenesis of atherosclerosis. Lab Invest 85: 9-23, 2005.
3. Davies PF. Flow-mediated endothelial mechanotransduction. Physiol Rev 75: 519-560, 1995.
4. Helmke BP, Thakker DB, Goldman RD, Davies PF. Spatiotemporal analysis of flow-induced intermediate filament displacement in living endothelial cells. Biophys J 80: 184-194, 2001.
5. Katsumi A, Orr AW, Tzima E, Schwartz MA. Integrins in Mechanotransduction. J Biol Chem 279: 12001-12004, 2004.
6. Li S, Butler P, Wang Y, Hu Y, Han DC, Usami S, Guan JL, Chien S. The role of the dynamics of focal adhesion kinase in the mechanotaxis of endothelial cells. Proc Natl Acad Sci USA 99: 3546-3551, 2002.
7. Li S, Chen BP, Azuma N, Hu YL, Wu SZ, Sumpio BE, Shyy JY, Chien S. Distinct roles for the small GTPases Cdc42 and Rho in endothelial responses to shear stress. J Clin Invest 103: 1141-1150, 1999.
8. Martinac B. Mechanosensitive ion channels: molecules of mechanotransduction. J Cell Sci 117: 2449-2460, 2004.
9. McCue S, Noria S, Langille BL. Shear-induced reorganization of endothelial cell cytoskeleton and adhesion complexes. Trends Cardiovasc Med 14: 143-151, 2004.
10. Mott RE, Helmke BP. Mapping the dynamics of shear stress-induced structural changes in endothelial cells. Am J Physiol Cell Physiol 293: C1616-C1626, 2007.
11. Osawa M, Masuda M, Kusano K, Fujiwara K. Evidence for a role of platelet endothelial cell adhesion molecule-1 in endothelial cell mechanosignal transduction: is it a mechanoresponsive molecules? J Cell Biol 158: 773-785, 2002.
12. Rizzo V, Sung A, Oh P, Schnitzer JE. Rapid mechanotransduction in situ at the luminal cell surface of vascular endothelium and its caveolae. J Biol Chem 273: 26323-26329, 1998.
13. Tzima E, Del Pozo MA, Kiosses WB, Mohamed SA, Li S, Chien S, Schwartz MA. Activation of Rac1 by shear stress in endothelial cells mediates both cytoskeletal reorganization and effects on gene expression. EMBO J 21: 6791-6800, 2002.
14. Weinbaum S, Zhang X, Han Y, Vink H, Cowin SC. Mechanotransduction and flow across the endothelial glycocalyx. Proc Natl Acad Sci USA 100: 7988-7995, 2003.