Facile regioselective synthesis of pyrazolo[5,1-α]isoquinolines via ring-opening cyclization/oxidation reactions of stable aroyldiaziridines of 3,4-tetrahydroisoquinoline with alkynes

Synthesis

Volumn , Issue 23, 2007, Pages 3683-3691

  Ortega, Heriberto ^a   Ahmed, Sara ^a   Alper, Howard ^a  

^a UNIVERSITY OF OTTAWA   (Canada)

Author keywords

Alkynes; Cycloadditions; Diaziridines; Isoquinolines; Oxidations

Indexed keywords

ALKYNES; DIAZIRIDINES; ISOQUINOLINES;

AROMATIZATION; CYCLIZATION; CYCLOADDITION; OXIDATION; REGIOSELECTIVITY; SYNTHESIS (CHEMICAL);

ORGANIC COMPOUNDS;

1 (2 ETHYL 5,6 DIHYDROPYRAZOLO[5,1 A]ISOQUINOLIN 1 YL)ETHANONE; 1 (2 PHENYL 5,6 DIHYDROPYRAZOLO[5,1 A]ISOQUINOLIN 1 YL)ETHANONE; 1 (TOLUENE 4 SULFONYL) 1,2,3,7B TETRAHYDRO 1 ,1A DIAZACYCLOPROPA NAPHTHALENE; 2 (4 BROMOPHENYL) 5,6 DIHYDROPYRAZOLO[5,1 A]ISOQUINOLINE; 2 (4 FLUOROPHENYL) 5,6 DIHYDROPYRAZOLO[5,1 A]ISOQUINOLINE; 2 (4 METHOXYPHENYL) 5,6 DIHYDROPYRAZOLO[5,1 A]ISOQUINOLINE; 2 (6 METHOXYNAPHTHALEN 2 YL) 5,6 DIHYDROPYRAZOLO[5,1 A]ISOQUINOLINE; 2 M TOLYL 5,6 DIHYDROPYRAZOLO[5,1 A]ISOQUINOLINE; 2 O TOTYL 5,6 DIHYDROPYRAZOLO[5,1 A]ISOQUINOLINE; 2 P TOLYL 5,6 DIHYDROPYRAZOLO[5,1 A]ISOQUINOLINE; 2 PHENYL 5,6 DIHYDROPYRAZOLO[5,1 A]ISOQUINOLINE; 2 PHENYL 6,10B DIHYDRO 5H PYRAZOLO[5,1 A]ISOQUINOLIN 3 YL P TOLYLMETHANONE; 3,4 TETRAHYDROISOQUINOLINE; 3,7B DIHYDRO 2H 1,1A DIAZACYCLOPROPA[A]NAPHTHALENE 1 CARBOXYLIC ACID 9H FLUOREN 9 YLMETHYL ESTER; ALKYNE; AROYLDIAZIRIDINE; DIOXANE; ISOQUINOLINE DERIVATIVE; OXYGEN; PYRAZOLINE DERIVATIVE; PYRAZOLO[5,1 A]ISOQUINOLINE; QUINOLINE DERIVATIVE; UNCLASSIFIED DRUG;

AROMATIZATION; ARTICLE; CATALYSIS; CHEMICAL REACTION; CONFORMATIONAL TRANSITION; CYCLIZATION; CYCLOADDITION; OXIDATION; RING OPENING; SUBSTITUTION REACTION; SYNTHESIS;

EID: 37049016664     PISSN: 00397881     EISSN: None     Source Type: Journal    
DOI: 10.1055/s-2007-990888     Document Type: Article

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