Effects of probucol on ox-LDL induced apoptosis and CD36, Caveolin-1 expression in THP-1 macrophages

Chinese Pharmacological Bulletin

Volumn 23, Issue 9, 2007, Pages

  Su, Bo ^a   He, Hui ^a   Luo, Qi Fi ^a   Zhu, Bing Yang ^a   Duan fang, Liao ^a  

^a UNIVERSITY OF SOUTH CHINA   (China)

Author keywords

Apoptosis; Caveolin 1; CD36; Macrophages; Ox LDL; Probucol

Indexed keywords

CASPASE 3; CAVEOLIN 1; LOW DENSITY LIPOPROTEIN; MESSENGER RNA; PROBUCOL;

APOPTOSIS; ARTICLE; DOWN REGULATION; DRUG EFFECT; FLOW CYTOMETRY; IMMUNOFLUORESCENCE; MACROPHAGE; PROTEIN EXPRESSION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION;

EID: 37049008677     PISSN: 10011978     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (12)

1. Ball R Y, Stowers E C, Burton J H, et al. Evidence that the death of macrophage foam cells contributes to the lipid core of atheroma [J]. Atherosclerosis, 1995,114(1):45-54.
2. Kinscherf R, Claus R, Wagner M, et al. Apoptosis caused by oxidized LDL is manganese superoxide dismutase and p53 dependent [J]. FASEB J, 1998,12(6):461-7.
3. Wang D, Ding H, Xu H Y, et al. Effect of lovastatin and probucol on intracellular cholesterol content in foam cells derived from mouse peritoneal macrophages[J]. Chin Pharmacol Bull, 2004,20 (6):680-4.
4. Braesen J H, Beisiegel U, Niendorf A. Probucol inhibits not only the progression of atherosclerotic disease, but causes a different composition of atherosclerotic lesions in WHHL-rabbits[J]. Virchows Arch, 1995,426(2):179-88.
5. Aoki M, Nata T, Morishita R, et al. Endothelial apoptosis induced by oxidative stress through activation of NF-κB: Antiapoptotic effect of antioxidant agents on endothelial cells[J]. Hypertension, 2001, 38(1):48-55.
6. Marchant C E, Law N S, van der Veen C, et al. Oxidized low-density lipoprotein is cytotoxic to human monocyte-macrophages: protection with lipophilic antioxidants[J]. FEBS Lett, 1995,358 (2):175-8.
7. Nicholson A C, Han J, Febbraio M, et al. Role of CD36, the macrophage class B scavenger receptor, in atherosclerosis[J]. Ann NY Acad Sci, 2001,947(1):224-8.
8. Frank P G, Lee H, Park D S, et al. Genetic ablation of Caveolin-1 confers protection against atherosclerosis[J]. Arterioscler Thromb Vasc Biol, 2004,24(1):98-105.
9. Wintergerst S, Jelk J, Rahner C, et al. Apoptosis induced by oxidized low density lipoprotein in human monocyte-derived macrophages involves CD36 and activation of caspase-3[J]. FEBS J, 2000,267(19):6050-9.
10. Gargalovic P, Dory L. Cellular apoptosis is associated with increased Caveolin-1 expression in macrophages[J]. J Lipid Res, 2003,44(9):1622-32.
11. Liao H S, Kodama T, Geng Y J. Expression of class A scavenger receptor inhibits apoptosis of macrophages triggered by oxidized low density lipoprotein and oxysterol[J]. Arterioscler Thromb Vasc Biol, 2000,20(8):1968- 75.
12. Febbraio M, Podrez E A, Smith J D, et al. Targeted disruption of the class B scavenger receptor CD36 protects against atherosclerotic lesion development in mice[J]. J Clin Invest, 2000,105(8):1049 -56.