Endothelial NO/cGMP-dependent vascular relaxation of cornuside isolated from the fruit of Cornus officinalis

Planta Medica

Volumn 73, Issue 14, 2007, Pages 1436-1440

  Dae, Gill Kang ^a,b   Deok, Ho Choi ^a   Jun, Kyoung Lee ^a   Yun, Jeong Lee ^a,b   Mi, Kyoung Moon ^a   Sun, Nye Yang ^a   Tae, Oh Kwon ^b   Ji, Woong Kwon ^b   Jin, Sook Kim ^c   Lee, Ho Sub ^a,b  

^a Wonkwang University   (South Korea)

^b Wonkwang University   (South Korea)

^c Korea Institute of Oriental Medicine (KIOM)   (South Korea)

Author keywords

Cornaceae; Cornus officinalis; Cornuside; Nitric oxide cGMP; Vasorelaxation

Indexed keywords

1H 1,2,4 OXADIAZOLO[4,3 A]QUINOXALIN 1 ONE; ATROPINE; CORNUS OFFICINALIS EXTRACT; CORNUSIDE; CYCLIC GMP; DILTIAZEM; ENDOTHELIUM DERIVED RELAXING FACTOR; GLIBENCLAMIDE; INDOMETACIN; N(G) NITROARGININE METHYL ESTER; NITRIC OXIDE; PROPRANOLOL; TETRYLAMMONIUM; UNCLASSIFIED DRUG; VERAPAMIL;

ANIMAL EXPERIMENT; ANIMAL TISSUE; AORTA; ARTICLE; BLOOD VESSEL TONE; CONTROLLED STUDY; CORNUS; CORNUS OFFICINALIS; DRUG MECHANISM; ENDOTHELIUM; ENDOTHELIUM CELL; HUMAN; HUMAN CELL; LEISURE; MALE; MEDICINAL PLANT; NONHUMAN; RAT; SPRAGUE DAWLEY RAT; UMBILICAL VEIN; VASODILATATION;

ANIMALS; AORTA; CORNUS; CYCLIC GMP; DOSE-RESPONSE RELATIONSHIP, DRUG; ENDOTHELIUM, VASCULAR; FRUIT; GLUCOSIDES; MALE; MOLECULAR STRUCTURE; NITRIC OXIDE; PYRANS; RATS; RATS, SPRAGUE-DAWLEY; VASODILATION;

CORNACEAE; CORNUS OFFICINALIS; RATTUS;

EID: 36949034713     PISSN: 00320943     EISSN: None     Source Type: Journal    
DOI: 10.1055/s-2007-990243     Document Type: Article

References (19)

1. Furchgott RF, Zawadzki JV. The obligatory role of endothelial cells in the relaxation of arterial smooth muscle by acetylcholine. Nature 1980; 288: 373-6.
2. Jaffe EA. Physiologic functions of normal endothelial cells. Ann NY Acad Sci 1985; 454: 279-91.
3. Beny JL, Brunet PC. Neither nitric oxide nor nitroglycerin accounts for all the characteristics of endothelially mediated vasodilatation of pig coronary arteries. Blood Vessels 1988; 25: 308-11.
4. Palmer RM, Ashton DS, Moncada S. Vascular endothelial cells synthesize nitric oxide from 1-arginine. Nature 1998; 333: 664-6.
5. Sato K, Ozaki H, Karaki H. Changes in cytosolic calcium level in vascular smooth muscle strip measured simultaneously with contraction using fluorescent calcium indicator fura 2. J Pharmacol Exp Ther 1988; 246: 294-300.
6. Zhao SP, Xue Z. Studies on the chemical constituents of Cornus officinalis Sieb et Zucc. Yao Xue Xue Bao 1992; 27: 845-8.
7. Hatano T, Yasuhara T, Abe R, Okuda T. A galloylated monoterpene glucoside and dimeric hydrolysable tannin from Cornus officinalis. Phytochemisty 1990; 29: 2975-8.
8. Damtoft S, Franzyk H, Jensen SR. Fontanesioside and 5-hydroxysecologanol from Fontanesia phillyreoides. Phytochemisty 1994; 35: 705-11.
9. de Martin R, Vanhove B, Cheng Q, Hofer E, Csizmadia V, Winkler H et al. Cytokine-inducible expression in endothelial cells of an I kappa B alpha-like gene is regulated by NF kappa B. EMBO J 1993; 12: 2773-9.
10. Kim SZ, Kim SH, Park JK, Koh GY, Cho KW. Presence and biological activity of C-type natriuretic peptide-dependent guanylate cyclase-coupled receptor in the penile corpus cavernosum. J Urol 1998; 159: 1741-6.
11. Standen NB, Quayle JM, Davies NW, Brayden JE, Huang Y, Nelson MT. Hyperpolarizing vasodilators activate ATP-sensitive K+ channels in arterial smooth muscle. Science 1989; 245: 177-80.
12. Loeb AL, Izzo NJ Jr, Johnson RM, Garrison JC, Peach MJ. Endothelium-derived relaxing factor release associated with increased endothelial cell inositol trisphosphate and intracellular calcium. Am J Cardiol 1988; 62: 36G-40G.
13. Gordon JL, Martin W. Stimulation of endothelial prostacyclin production plays no role in endothelium-dependent relaxation of the pig aorta. Br J Pharmacol 1983; 80: 179-86.
14. Satake N, Kiyoto S, Shibata S, Gandhi V, Jones DJ, Morikawa M. Possible mechanisms of inhibition with atropine against noradrenaline-induced contraction in the rabbit aorta. Br J Pharmacol 1992; 107: 553-8.
15. Rapoport RM, Draznin MB, Murad F. Endothelium-dependent relaxation in rat aorta may be mediated through cyclic GMP-dependent protein phosphorylation. Nature 1983; 306: 174-6.
16. Kang DG, Sohn EJ, Kwon EK, Han JH, Oh H, Lee HS. Effects of berberine on angiotensin-converting enzyme and NO/cGMP system in vessels. Vasc Pharmacol 2002; 39: 281-6.
17. Kang DG, Moon MK, Choi DH, Lee JK, Kwon TO, Lee HS. Vasodilatory and anti-inflammatory effects of the 1,2,3,4,6-penta-O-galloyl-beta- D-glucose (PGG) via a nitric oxide-cGMP pathway. Eur J Pharmacol 2005; 524: 111-9.
18. Kang DG, Yin MH, Oh H, Lee DH, Lee HS. Vasorelaxation by amentoflavone isolated from Selaginella tamariscina. Planta Med 2004; 70: 718-22.
19. Wong IY, Huang Y, He ZD, Lau CW, Chen ZY. Relaxing effects of Ligstrum purpurascens extract and purified acteoside in rat aortic rings. Planta Med 2001; 67: 317-21.