Physical mechanical and tablet formation properties of hydroxypropylcellulose: In pure form and in mixtures

AAPS PharmSciTech

Volumn 8, Issue 4, 2007, Pages

  Picker Freyer, Katharina M ^a   Dürig, Thomas ^b  

^a MARTIN LUTHER UNIVERSITY HALLE WITTENBERG   (Germany)

^b Hercules Incorporated   (United States)

Author keywords

3 D; DSC; Elastic recovery; Hydroxypropylcellulose; Mixtures; Modeling; Plastic deformation; Tableting

Indexed keywords

CALCIUM PHOSPHATE DIBASIC; EXCIPIENT; HYDROXYPROPYLCELLULOSE; LACTOSE; MICROCRYSTALLINE CELLULOSE; CALCIUM PHOSPHATE; CELLULOSE; DRUG DERIVATIVE; WATER;

ARTICLE; CONTROLLED STUDY; DIFFERENTIAL SCANNING CALORIMETRY; ELASTICITY; HEAT SENSITIVITY; HUMIDITY; MATERIALS TESTING; MOLECULAR WEIGHT; PARTICLE SIZE; PHYSICAL CHEMISTRY; PLASTICITY; PURIFICATION; STATISTICAL MODEL; TABLET COMPRESSION; TABLET FORMULATION; TABLET HARDNESS; TABLET MACHINE; TABLET PROPERTY; VISCOSITY; CHEMICAL MODEL; CHEMISTRY; COMPRESSIVE STRENGTH; DRUG FORMULATION; METHODOLOGY; PHARMACEUTICS; POROSITY; POWDER; PRESSURE; TABLET; TENSILE STRENGTH; TIME; TRANSITION TEMPERATURE;

CALCIUM PHOSPHATES; CELLULOSE; CHEMISTRY, PHARMACEUTICAL; COMPRESSIVE STRENGTH; DRUG COMPOUNDING; ELASTICITY; EXCIPIENTS; HUMIDITY; LACTOSE; MODELS, CHEMICAL; MOLECULAR WEIGHT; PARTICLE SIZE; POROSITY; POWDERS; PRESSURE; TABLETS; TECHNOLOGY, PHARMACEUTICAL; TENSILE STRENGTH; TIME FACTORS; TRANSITION TEMPERATURE; VISCOSITY; WATER;

EID: 36949013437     PISSN: None     EISSN: 15309932     Source Type: Journal    
DOI: 10.1208/pt0804092     Document Type: Article

References (21)

1. Thielmann F, Burnett D, Lusvardi KM, Dürig T. Correlating drug-binder adhesive strengths measured using inverse gas chromatography with tablet performance. Int J Pharm. 2006;In press.
2. Kristensen HG. Binders. In: Swarbrick J, Boylan JC, eds. Encyclopedia of Pharmaceutical Technology. vol. 1. New York, NY: Marcel Dekker Inc; 1988.
3. Nyström C, Mazur J, Sjögren J. Studies on direct compression of tablets. II. The influence of the particle size of a dry binder on the mechanical strength of tablets. Int J Pharm. 1982; 10:209-218.
4. Krycer I, Pope DG. An evaluation of tablet binding agents. Part I. Solution binders. Powder Technol. 1983;134:39-51.
5. Krycer I, Pope DG. An evaluation of tablet binding agents. Part II. Pressure binders. Powder Technol.1983;34:53-56.
6. Selmeczi B, Kereszted A, Rapo J. Influence of cellulosic derivatives on several parameters of tablets. Acta Pharm Hung. 1975;45:28-36.
7. Alvarez-Lorenzo C, Gomez-Amoza JL, Martinez-Pacheco R, Souto C, Concheiro A. Evaluation of low-substituted hydroxypropycelluloses (LHPCs) as filler-binders for direct compression. Int J Pharm. 2000;197:107-116.
8. Skinner GW, Harcum WW, Barnum PE, Guo JH. The evaluation of fine-particle hydroxypropylcellulose as a roller compaction binder in pharmaceutical applications. Drug Dev Ind Pharm. 1999;25: 1121-1128.
9. Harcum WW, Skinner GW, Altekar M, Joneja SK, Barnum PE, Guo JH. Modeling the effects of hydroxypropylcellulose in acetaminophen tablet formation. Drug Dev Ind Pharm. 1998;24:911-918.
10. Joneja SK, Harcum WW, Skinner GW, Barnum PE, Guo JH. Investigating the fundamental effects of binders on pharmaceutical tablet performance. Drug Dev Ind Pharm. 1999;25:1129-1135.
11. Suto S, Kudo M, Karasawa M. Static tensile and dynamic mechanical properties of hydroxypropylcellulose film prepared under various conditions. J Appl Pol Sci. 1986;31:1327-1341.
12. Rials TG, Glaser WG. Thermal and dynamic mechanical properties of hydroxy-propylcellulose films. J Appl Polym Sci. 1988;36: 749-758.
13. Kararli TT, Hurlbut JB, Needham TE. Glass-rubber transition of cellulosic polymers by dynamic mechanical analysis. J Pharm Sci. 1990;79:845-848.
14. Picker KM. A new theoretical model to characterize the densification behavior of tableting materials. Eur J Pharm Biopharm. 2000;49: 267-273.
15. Picker KM. The 3D model: explaining densification and deformation mechanisms by using 3D parameter plots. Drug Dev Ind Pharm. 2004;30:413-425.
16. Carr RL. Evaluating flow properties of solids. Chem Eng. 1965;72:163-168.
17. Heckel RW. An analysis of powder compaction phenomena. Trans Metall Soc AIME. 1961;221:1001-1008.
18. Heckel RW. Density-pressure relationships in powder compaction. Trans Metall Soc AIME. 1961;221:671-675.
19. Hancock BC, Zografi G. Characteristics and significance of the amorphous state in pharmaceutical systems. J Pharm Sci. 1997;86:1-12.
20. Picker KM, Hoag SW. Characterization of the thermal properties of microcrystalline cellulose by modulated temperature differential scanning calorimetry. J Pharm Sci. 2002;91:342-349.
21. Billmeyer FW. Textbook of Polymer Science. New York, NY: Wiley; 1984:341-342.