sHLA-G levels in the monitoring of immunosuppressive therapy and rejection following heart transplantation

Transplant Immunology

Volumn 17, Issue 1, 2006, Pages 70-73

  Luque, J ^a   Torres, M I ^b   Aumente, M D ^a   Lozano, J M ^a   Garcia Jurado G ^a   Gonzalez R ^a   Alvarez Lopez M R ^c   Arizon J M ^a   Pena J ^a  

^a HOSPITAL UNIVERSITARIO REINA SOFÍA   (Spain)

^b UNIVERSITY OF JAÉN   (Spain)

^c SN Hospital Virgen de la Arraixaca   (Spain)

Author keywords

Cyclosporine; Heart transplantation; Immunosuppressive treatment; sHLA G; Tolerance

Indexed keywords

CYCLOSPORIN A; EVEROLIMUS; HLA G ANTIGEN; METHYLPREDNISOLONE; MYCOPHENOLIC ACID 2 MORPHOLINOETHYL ESTER; TACROLIMUS;

ADULT; ALLOGRAFT; ARTICLE; BLOOD LEVEL; CARDIAC GRAFT REJECTION; CLINICAL ARTICLE; CONTROLLED STUDY; FEMALE; HEART GRAFT; HEART TRANSPLANTATION; HUMAN; IMMUNOSUPPRESSIVE TREATMENT; MALE; PRIORITY JOURNAL; PROGNOSIS;

ACUTE DISEASE; ADOLESCENT; ADULT; FEMALE; GRAFT REJECTION; HEART TRANSPLANTATION; HISTOCOMPATIBILITY ANTIGENS CLASS I; HLA ANTIGENS; HUMANS; IMMUNOSUPPRESSIVE AGENTS; MALE; MIDDLE AGED; PROGNOSIS; SOLUBILITY; TRANSPLANTATION TOLERANCE;

EID: 36949009704     PISSN: 09663274     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.trim.2006.09.009     Document Type: Article

References (18)

1. Lemaoult J., Rouas-Freiss N., and Carosella E.D. Immuno-tolerogenic functions of HLA-G: relevance in transplantation and oncology. Autoimmun Rev 4 (2005) 503-509
2. Lemaoult J., Le D.M., Rouas-Freiss N., Moreau P., Menier C., McCluskey J., et al. Biology and functions of human leukocyte antigen-G in health and sickness. Tissue Antigens 62 (2003) 273-284
3. O'Callaghan C.A., and Bell J.I. Structure and function of the human MHC class Ib molecules HLA-E, HLA-F and HLA-G. Immunol Rev 163 (1998) 129-138
4. Shiroishi M., Tsumoto K., Amano K., Shirakihara Y., Colonna M., Braud V.M., et al. Human inhibitory receptors Ig-like transcript 2 (ILT2) and ILT4 compete with CD8 for MHC class I binding and bind preferentially to HLA-G. Proc Natl Acad Sci U S A 100 (2003) 8856-8861
5. Navarro F., Llano M., Bellon T., Colonna M., Geraghty D.E., and Lopez-Botet M. The ILT2(LIR1) and CD94/NKG2A NK cell receptors respectively recognize HLA-G1 and HLA-E molecules co-expressed on target cells. Eur J Immunol 29 (1999) 277-283
6. Lila N., Carpentier A., Amrein C., Khalil-Daher I., Dausset J., and Carosella E.D. Implication of HLA-G molecule in heart-graft acceptance. Lancet 355 (2000) 2138
7. Creput C., Le F.G., Bahri R., Amiot L., Charpentier B., Carosella E., et al. Detection of HLA-G in serum and graft biopsy associated with fewer acute rejections following combined liver-kidney transplantation: possible implications for monitoring patients. Hum Immunol 64 (2003) 1033-1038
8. Qiu J., Terasaki PI., Miller J., Mizutani K., Cai J., and Carosella ED. Soluble HLA-G Expression and Renal Graft Acceptance. Am J Transplant 6 (2006) 2152-2156
9. Ristich V., Liang S., Zhang W., Wu J., and Horuzsko A. Tolerization of dendritic cells by HLA-G. Eur J Immunol 35 (2005) 1133-1142
10. Le R.S., Le M.J., Creput C., Menier C., Deschamps M., Le F.G., et al. Alloreactive CD4+ and CD8+ T cells express the immunotolerant HLA-G molecule in mixed lymphocyte reactions: in vivo implications in transplanted patients. Eur J Immunol 34 (2004) 649-660
11. Fournel S., guerre-Girr M., Huc X., Lenfant F., Alam A., Toubert A., et al. Cutting edge: soluble HLA-G1 triggers CD95/CD95 ligand-mediated apoptosis in activated CD8+ cells by interacting with CD8. J Immunol 164 (2000) 6100-6104
12. Lila N., Amrein C., Guillemain R., Chevalier P., Latremouille C., Fabiani J.N., et al. Human leukocyte antigen-G expression after heart transplantation is associated with a reduced incidence of rejection. Circulation 105 (2002) 1949-1954
13. Luque J., Torres M.I., Aumente M.D., Marin J., Garcia-Jurado G., Gonzalez R., et al. Soluble HLA-G in heart transplantation: their relationship to rejection episodes and immunosuppressive therapy. Hum Immunol 67 (2006) 257-263
14. Frustaci A., Chimenti C., Calabrese F., Pieroni M., Thiene G., and Maseri A. Immunosuppressive therapy for active lymphocytic myocarditis: virological and immunologic profile of responders versus nonresponders. Circulation 107 (2003) 857-863
15. Aumente-Rubio M.D., Arizon J.M., Lopez Malo M.D., Cardenas A.M., Segura Saint-Gerons J., Lopez G.A., et al. Clinical pharmacokinetics of tacrolimus in heart transplantation: new strategies of monitoring. Transplant Proc 35 (2003) 1988-1991
16. Rouas-Freiss N., Lemaoult J., Moreau P., Dausset J., and Carosella E.D. HLA-G in transplantation: a relevant molecule for inhibition of graft rejection?. Am J Transplant 3 (2003) 11-16
17. Moreau P., Faure O., Lefebvre S., Ibrahim E.C., O'Brien M., Gourand L., et al. Glucocorticoid hormones upregulate levels of HLA-G transcripts in trophoblasts. Transplant Proc 33 (2001) 2277-2280
18. Le Rond., Azema C., Krawice-Radanne I., Durrbach A., Guettier C., Carosella E.D., et al. Evidence to support the role of HLA-G5 in allograft acceptance through induction of immunosuppressive/regulatory T cells. J Immunol 176 (2006) 3266-3276