Structure and function of the human MHC class Ib molecules HLA-E, HLA-F and HLA-G

Immunological Reviews

Volumn 163, Issue , 1998, Pages 129-138

  O'Callaghan, Christopher A ^a   Bell, John I ^a  

^a UNIVERSITY OF OXFORD   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

HLA E ANTIGEN; HLA G ANTIGEN; ISOLEUCINE; LEUCINE; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 1; PROLINE; SIGNAL PEPTIDE; UNCLASSIFIED DRUG;

AMINO ACID SEQUENCE; CELL SURFACE; MAJOR HISTOCOMPATIBILITY COMPLEX; MOLECULAR RECOGNITION; NATURAL KILLER CELL; PRIORITY JOURNAL; PROTEIN TERTIARY STRUCTURE; REVIEW;

AMINO ACID SEQUENCE; HISTOCOMPATIBILITY ANTIGENS CLASS I; HLA ANTIGENS; HUMANS; MOLECULAR SEQUENCE DATA; PROTEIN CONFORMATION; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 0031815489     PISSN: 01052896     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1600-065X.1998.tb01192.x     Document Type: Review

References (51)

1. Townsend A, Bodmer H. Antigen recognition by class-I restricted lymphocytes. Annu Rev Immunol 1989;7:601-624.
2. Bjorkman PJ, Parham P. Structure, function and diversity of class I major histocompatibility complex molecules. Annu Rev Biochem 1990;59:253-288.
3. Madden DR. The three-dimensional structure of peptide- MHC complexes. Annu Rev Immunol 1995;13:587-622.
4. Shawar SM, Vyas JM, Rodgers JR, Rich RR. Antigen presentation by major histocompatibility complex class Ib molecules. Annu Rev Immunol 1994;12:839-880.
5. Geraghty DE, Koller BH, Hansen JA, Orr HT. The HLA class I gene family includes at least six genes and twelve pseudogenes and gene fragments. J Immunol 1992;149:1934-1946.
6. Shimuzu Y, Geraghty DE, Koller BH, Orr HT, DeMars R. Transfer and expression of three cloned human non-HLA-A, B, C class I major histocompatibility complex genes in mutant lymphoblastoid cells. Proc Natl Acad Sci USA 1988;85:227-231.
7. Gao GF, et al. Crystal structure of the complex between CD8 alpha-alpha and HLA-A2. Nature 1997;387:630-634.
8. Braud V, et al. HLA-E binds to natural killer cell receptors CD94/NKG2A, B and C. Nature 1998;391:795-799.
9. Perez-Villar JJ, et al. The CD94/NKG2-A inhibitory receptor complex is involved in natural killer cell-mediated recognition of cells expressing HLA-G1. J Immunol 1997;158:5736-5743.
10. Soderstrom K, Corliss B, Lanier LL, Phillips JH. CD94/NKG2 is the predominant inhibitory receptor involved in recognition of HLA-G by decidual and peripheral blood NK cells. J Immunol 1997;159:1072-1075.
11. Connolly DJ, et al. A cDNA clone encoding the mouse Qa-1a histocompatibility antigen and proposed structure of the putative peptide binding site. J Immunol 1993;151:6089-6098.
12. Aldrich CJ, DeCloux A, Woods AS, Cotter RJ, Soloski MJ, Forman J. Identification of a Tap-dependent leader peptide recognized by alloreactive T cells specific for a class Ib antigen. Cell 1994;79:649-658.
13. Kurepa Z, Forman J. Peptide binding to the class Ib molecule Qa-1b. J Immunol 1997;158:3244-3251.
14. DeCloux A, Woods AS, Cotter RJ, Soloski MJ, Forman J. Dominance of a single peptide bound to the Class Ib molecule Qa-1b. J Immunol 1997;158:2183-2191.
15. Cotterill LA, et al. Qa-1 interaction and T cell recognition of the Qa-1 determinant modifier peptide. Eur J Immunol 1997;27:2123-2132.
16. Henderson RA, et al. HLA-A2.1-associated peptides from a mutant cell line: a second pathway for antigen presentation. Science 1992;255:1264-1266.
17. Lowen LC, Aldrich CJ, Forman J. Analysis of T cell receptors specific for recognition of class Ib antigens. J Immunol 1993;151:6155-6165.
18. Vidovic D, Roglic M, McKune K, Guerder S, MacKay C, Dembic Z. Qa-1 restricted recognition of foreign antigen by a gamma-delta T-cell hybridoma. Nature 1989;340:646-648.
19. Ulbrecht M, Kellerman J, Johnson JP, Weiss EH. Impaired intracellular transport and cell surface expression on non polymorphic HLA-E: evidence for inefficient peptide binding. J Exp Med 1992;176:1083-1090.
20. Geraghty DE, et al. Abstract. 12th International Histocompatibility Workshop and Conference; 1996 June 3-8; Paris, France.
21. Braud V, Jones EY, McMichael AJ. The human major histocompatibility complex class Ib molecule HLA-E binds signal sequence derived peptides with primary anchor residues at positions 2 and 9. Eur J Immunol 1997;27:1164-1169.
22. Braud V, Allan DS, Wilson D, McMichael AJ. TAP and tapasin-dependent HLA-E surface expression correlates with the binding of an MHC class I leader peptide. Curr Biol 1998;8:1-10.
23. O'Callaghan CA, et al. Production, crystallization and preliminary x-ray analysis of the human class Ib MHC molecule HLA-E. Protein Sci 1998 (In press).
24. Altman JD. et al. Phenotypic analysis of antigen-specific T lymphocytes. Science 1996;274:94-96.
25. Borrego F, Ulbrecht M, Weiss EH, Coligan JE, Brooks AG. Recognition of Human Histocompatibility Leukocyte antigen (HLA)-E complexed with HLA class I signal sequence-derived peptides by CD94/NKG2 confers protection from natural killer cell-mediated lysis. J Exp Med 1998;187:813-818.
26. Lee N, et al. HLA-E is a major ligand for the NK inhibitory receptor CD94/NKG2A. Proc Natl Acad Sci USA 1998 (In press).
27. O'Callaghan CA, et al. Structural features impose tight peptide binding specificity in the nonclassical MHC molecule HLA-E. Molecular Cell 1998;1:531-541.
28. Saper MA, Bjorkman PJ, Wiley DC. Refined structure of human histocompatibility antigen HLA-A2 at 2.6 Angstrom resolution. J Mol Biol 1991;219:277-319.
29. Garboczi DN, Ghosh P, Utz U, Fan QR, Biddison WE, Wiley DC. Structure of the complex between the human T-cell receptor, viral peptide and HLA-A2. Nature 1996;384:134-141.
30. Boyson JE, et al. The MHC-E locus in macaques is polymorphic and is conserved between macaques and humans. Immunogenetics 1995;41:59-68.
31. Alvarez M, et al. High polymorphism of MHC-E locus in non human primates: alleles with identical exon 2 and 3 are found in two different species. Tissue Antigens 1997;49:160-167.
32. Barnes PD, Grundy JE. Down regulation of class I HLA heterodimer and beta 2-microglobulin on the surface of cells infected with cytomegalovirus. J Gen Virol 1992;73:2395-2403.
33. Fruh K, et al. A viral inhibitor of peptide transporters for antigen presentation. Nature 1995;375:415-418.
34. Wei X, Orr HT. Differential expression of HLA-E, HLA-F and HLA-G transcripts in human tissues. Hum Immunol 1990;29:131-142.
35. Geraghty DE, Wei X, Orr HT, Koller BH. Human leukocyte antigen F (HLA-F). An expressed HLA gene composed of a class I coding sequence linked to a novel transcribed repetitive element. J Exp Med 1990;171:1-18.
36. Uchigiri C, et al. An identification of the HLA-F null allele in Japanese. Immunogenetics 1997;45:466-467.
37. Geraghty DE, Koller BH, Orr HT. A human major histocompatibility complex class I gene that encodes a protein with a shortened cytoplasmic segment. Proc Natl Acad Sci USA 1987;84:9145-9149.
38. Sanders SK, Giblin PA, Kavathas P. Cell-cell adhesion mediated by CD8 and human histocompatibility leukocyte antigen G, a nonclassical major histocompatibility complex class I molecule on cytotrophoblasts. J Exp Med 1991;174:737-740.
39. Van der Ven K, Ober C. HLA-G polymorphism in African Americans. J Immunol 1994;153:5628-5633.
40. Le Bouteiller P, Lenfant F. Antigen-presenting functions of the non-classical HLA-E, -F and -G class I molecules: the beginning of a story. Res Immunol 1996;147:301-313.
41. McMaster MT, et al. Human placental HLA-G expression is restricted to differentiated cytotrophoblasts. J Immunol 1995;154:3771-3778.
42. Le Bouteiller P. HLA class I chromosomal region, genes and products: facts and questions. Crit Rev Immunol 1994;14:89-129.
43. Fujii T, Ishitani A, Geraghty DE. An incompletely spliced message encodes the soluble form of HLA-G. J Immunol 1994;153:5516-5524.
44. Lee N, et al. The membrane-bound and soluble forms of HLA-G bind identical sets of endogenous peptides but differ with respect to TAP association. Immunity 1995;3:591-600.
45. Diehl M, et al. Nonclassical HLA-G molecules are classical peptide presenters. Curr Biol 1996;6:305-314.
46. Shukla H, Swaroop A, Srivastava R, Weissman SM. The mRNA of a human class I gene HLA-G/HLA 6.0 exhibits a restricted pattern of expression. Nucleic Acids Res 1990;18:2189.
47. Crisa L, McMaster MT, Ishii JK, Fisher SJ, Salomon DR. Identification of a thymic epithelial subset sharing expression of the class Ib HLA-G molecule with fetal trophoblasts. J Exp Med 1997;186:289-298.
48. King A, et al. Evidence for the expression of HLA-C class I mRNA and protein by human first trimester trophoblast. J Immunol 1996;156:2068-2076.
49. Chumbley G, King A, Robertson K, Holmes N, Loke YW. Resistance of HLA-G and HLA-A2 transfectants to lysis by decidual NK cells. Cell Immunol 1994;155:312-322.
50. Deniz G, Christmas SE, Brew R, Johnson PM. Phenotypic and functional cellular differences between CD3- decidual and peripheral blood leukocytes. J Immunol 1994;152:4255-4261.
51. Pazmany L, Mandelboim O, Valès-Gómez M, Davis DM, Reyburn HT, Strominger JL. Protection from natural killer cell mediated lysis by HLA-G expression on target cells. Science 1996;274:792-795.