2′,4′-BNANC: A novel bridged nucleic acid analogue with excellent hybridizing and nuclease resistance profiles

Nucleosides, Nucleotides and Nucleic Acids

Volumn 26, Issue 10-12, 2007, Pages 1625-1628

  Rahman, S M Abdur ^a,c   Seki, Sayori ^a   Utsuki, Kazushige ^a   Obika, Satoshi ^a,b   Miyashita, Kazuyuki ^a   Imanishi, Takeshi ^a  

^a OSAKA UNIVERSITY   (Japan)

^b JAPAN SCIENCE AND TECHNOLOGY AGENCY   (Japan)

^c UNIVERSITY OF DHAKA   (Bangladesh)

Author keywords

BNA; Nuclease resistance; Oligonucleotide; Stability

Indexed keywords

NUCLEASE; NUCLEOSIDE DERIVATIVE; 2',4' BNA(NC); 2',4'-BNA(NC); BRIDGED COMPOUND; DNA; ENDONUCLEASE; NUCLEOTIDE; OLIGONUCLEOTIDE; UNCLASSIFIED DRUG;

ARTICLE; CHEMICAL MODIFICATION; DRUG SYNTHESIS; HYBRIDIZATION; MOLECULAR DYNAMICS; PH MEASUREMENT; PHYSICAL CHEMISTRY; STRUCTURE ANALYSIS; SUPRAMOLECULAR CHEMISTRY; CHEMISTRY; HEAT; NUCLEIC ACID HYBRIDIZATION;

BRIDGED COMPOUNDS; DNA; ENDONUCLEASES; HEAT; NUCLEIC ACID HYBRIDIZATION; NUCLEOTIDES; OLIGONUCLEOTIDES;

EID: 36949002749     PISSN: 15257770     EISSN: 15322335     Source Type: Journal    
DOI: 10.1080/15257770701548980     Document Type: Article

References (9)

1. Stein, C.A.; King, A.M. Applied Antisense Oligonucleotide Technology, Willy-Liss, New York, 1998.
2. Buchini, S.; Leumann, C.J. Recent improvement in antigene technology. Curr. Opin. Chem. Biol. 2003, 7, 117-130.
3. Imanishi, T.; Obika, S. BNAs: Novel nucleic acid analogues with a bridged sugar moiety. Chem. Commun. 2002, 1653-1659.
4. Obika, S.; Nandu, D.; Hari, Y.; Morio, K.; In, Y.; Ishida, T.; Imanishi, T. Synthesis of 2′-O-4′-C-methyleneuridine and -cytidine novel bicyclic nucleosides having a fixed C3′-endo sugar puckering. Tetrahedron Lett. 1997, 38, 8735-8738.
5. Sing, S.K.; Nielsen, P.; Koshkin, A.A.; Wengel, J. LNA (locked nucleic acids): Synthesis and high affinity nucleic acid recognition. Chem. Commun. 1998, 455-456.
6. Petersen, M.;Wengel, J. LNA: A versatile tool for therapeutics and genomics. Trends. Biotechnol. 2003, 21, 74-81.
7. Jespen, J.S.; Wengel, J. Locked nucleic acid: A potent nucleic acid analogue in therapeutics and biotechnology. Curr. Opin. Drug Discovery Dev. 2004, 7, 188-194.
8. Hari, Y.; Obika, S.; Ohnishi, K.; Eguchi, K.; Osaki, T.; Ohishi, H.; Imanishi, T. Synthesis and properties of 2′-O,4′-C methyleneoxomethylene bridged nucleic acids. Biorg. Med. Chem. 2006, 14, 1029-1038.
9. NC, a second-generation BNA. Nucleic Acids Symp. Ser. 2005, 49, 5-6.