Expeditious synthesis of steroids containing a 2-methylsulfanyl-acetyl side chain as potential glucocorticoid receptor imaging agents

Steroids

Volumn 73, Issue 1, 2008, Pages 69-76

  Wuest, Frank ^a   Carlson, Kathryn E ^b   Katzenellenbogen, John A ^b  

^a INSTITUTE OF ION BEAM PHYSICS AND MATERIALS RESEARCH   (Germany)

^b UNIVERSITY OF ILLINOIS AT URBANA CHAMPAIGN   (United States)

Author keywords

Carbon 11; Glucocorticoid receptor binding; Mitsunobu reaction; Positron emission tomography (PET)

Indexed keywords

21 BENZYLTHIO 9ALPHA FLUORO 17ALPHA 17 O ISOPROPYLIDENE 11BETA,17ALPHA,17ALPHA TRIHYDROXY 1,4 PREGNADIENE 3,20 DIONE; 21 METHYLTHIO 9ALPHA FLUORO 16ALPHA 17 O ISOPROPYLIDENE 11BETA,16ALPHA,17ALPHA TRIHYDROXY 1,4 PREGNADIENE 3,20 DIONE; BENZOIC ACID DERIVATIVE; CARBON 11; DEXAMETHASONE; GLUCOCORTICOID; GLUCOCORTICOID RECEPTOR; HYDROCORTISONE; METHYL GROUP; METHYL IODIDE; PREDNISOLONE; THIOBENZOIC ACID; TRIAMCINOLONE ACETONIDE; TRITIUM; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; BINDING AFFINITY; CARBON NUCLEAR MAGNETIC RESONANCE; DRUG PURITY; DRUG RECEPTOR BINDING; DRUG STRUCTURE; DRUG SYNTHESIS; LIVER; MALE; MITSUNOBU REACTION; NONHUMAN; POSITRON EMISSION TOMOGRAPHY; PROTON NUCLEAR MAGNETIC RESONANCE; RAT; REACTION ANALYSIS; SAPONIFICATION; STRUCTURE ANALYSIS;

BINDING, COMPETITIVE; CARBON RADIOISOTOPES; DEXAMETHASONE; GLUCOCORTICOIDS; MODELS, CHEMICAL; MOLECULAR STRUCTURE; POSITRON-EMISSION TOMOGRAPHY; RECEPTORS, GLUCOCORTICOID; STEROIDS;

EID: 36849095486     PISSN: 0039128X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.steroids.2007.08.013     Document Type: Article

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