In-vivo and in-vitro studies on the effect of Huang-Lian-Jie-Du-Tang on nimodipine transport across rat blood-brain barrier

Journal of Pharmacy and Pharmacology

Volumn 59, Issue 12, 2007, Pages 1733-1738

  Dong, Mei Zhang ^a   Zhen, Wei He ^b   Liu, Xiao Dong ^a   Li, Yang ^a   Xie, Lin ^a   Guang, Ji Wang ^b   Liu, Li ^a  

^a CHINA PHARMACEUTICAL UNIVERSITY   (China)

^b First People's Hospital of Nantong   (China)

Author keywords

[No Author keywords available]

Indexed keywords

CHINESE DRUG; GLYCOPROTEIN P; HERBACEOUS AGENT; HUANG LIAN JIE DU TANG EXTRACT; NIMODIPINE; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; BLOOD BRAIN BARRIER; CELL CULTURE; CONFERENCE PAPER; CONTROLLED STUDY; DRUG TRANSPORT; ENDOTHELIUM CELL; IN VITRO STUDY; IN VIVO STUDY; MALE; MICROVASCULATURE; NEWBORN; NONHUMAN; PROTEIN EXPRESSION; RAT;

ANIMALS; AREA UNDER CURVE; BIOLOGICAL TRANSPORT; BLOOD-BRAIN BARRIER; BLOTTING, WESTERN; BRAIN; CALCIUM CHANNEL BLOCKERS; CAPILLARIES; CELLS, CULTURED; DRUGS, CHINESE HERBAL; ENDOTHELIAL CELLS; MALE; METABOLIC CLEARANCE RATE; NIMODIPINE; P-GLYCOPROTEIN; PLANT EXTRACTS; RATS; RATS, SPRAGUE-DAWLEY; RHODAMINE 123; SERUM;

EID: 36849094927     PISSN: 00223573     EISSN: None     Source Type: Journal    
DOI: 10.1211/jpp.59.12.0017     Document Type: Conference Paper

References (26)

1. Ando, H., Nishio, Y., Ito, K., Nakao, A., Wang, L., Zhao, Y. L. (2001) Effect of endotoxin on P-glycoprotein mediated biliary and renal excretion of rhodamine-123 in rats. Antimicrob. Agents. Chemother. 45: 3462-3467
2. Audus, K. L., Borchardt, R. T. (1986) Characterization of an in vitro blood-brain barrier model system for studying drug transport and metabolism. Pharm. Res. 3: 81-87
3. Bradford, M. M. (1976) A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal. Biochem. 72: 248-254
4. Dhananjay P., Ashim K. (2006) MDR- and CYP3A4-mediated drug-herbal interactions. Life Sci. 78: 2131-2145
5. Fuhr, U., Maierbruggemann, A., Blume, H., Muca, W., Unger, S., Kuhcmann, J. (1998) Grapefruit juice increases oral nimodipine bioavailability. Int. J. Clin. Pharmacol. Ther. 36: 126-132
6. Fujiwara, M., Iwasaki, K. (1993) Toki-shakuyaku-San and Oren-Gedoku-To improve the disruption of spatial cognition induced by cerebral ischemia and central cholinergic dysfunction in rats. Phytother. Res. 7: S60-S62
7. Higasa, K., Hatake, K., Higasa, M., Hishida, S. (1992) Vasorelaxant effects of Oren-gedoku-to and its four constituent herbs. J. Med. Pharm. Soc. 9: 169-174
8. Hwang, Y., Shin, C., Huh, Y., Ryu, J. (2002) Hwangryun-Hae-Dok-tang (Huanglian-Jie-Du-Tang) extract and its constituents reduce ischemia-reperfusion brain injury and neutrophil infiltration in rats. Life Sci. 71: 2105-2117
9. Kondo, Y., Kondo, F., Asanuma, M., Tanaka, K., Ogawa, N. (2000) Protective effect of oren-gedoku-to against induction of neuronal death by transient cerebral ischemia in the C57BL/6 mouse. Neurochem. Res. 25: 205-209
10. Liu, X., Zhang, L., Xie, L. (2003) Effect of P-glycoprotein inhibitors erythromycin and cyclosporin A on brain pharmacokinetics of nimodipine in rats. Eur. J. Drug Metab. Pharmacokinet. 28: 309-313
11. Ljunggren, B., Brandt, L., Saveland, H., Romner, B., Ryman, T., Anderson, K. E. (1987) Aneurysmal subarachnoid hemorrhage: prevention of delayed ischemic dysfunction with intravenous nimodipine. Neurosurg. Rev. 10: 255-263
12. Lu, T., Song, J., Xie, L., Wang, G., Liu, X. (2005) Simultaneous determination of baicalin and wogonoside by HPLC in rat plasma administrated with Huangqin decoction and its pharmacokinetic study. Zhong Cao Yao. 36: 870-873
13. Lu, T., Liang, Y., Song, J., Xie, L., Wang, G., Liu, X. (2006) Simultaneous determination of berberine and palmatine in rat plasma by HPLC-ESI-MS after oral administration of traditional Chinese medicinal preparation Huang-Lian-Jie-Du decoction and the pharmacokinetic application of the method. J. Pharm. Biomed. Anal. 40: 1218-1224
14. Mizukawa, H., Yoshida, K., Honmura, A., Uchiyama, Y., Kaku, H., Nakajima, S., Haruki, E. (1993) The effect of orengedokuto on experimentally-inflamed rats. Am. J. Chin. Med. 21: 71-78
15. Mohr, J. P., Orgogozo, J. M., Harrison, M. J. G., Hennerici, M., Wahlgren, N. G., Gelmers, H. I. (1994) Meta-analysis of oral nimodipine trials in acute ischemic stroke. Cerebrovasc. Dis. 4: 177-210
16. Ohta, Y., Sasaki, E., Nishida, K., Hayashi, T., Nagata M., Ishiguro, I. (1997) Preventive effect of Oren-gedoku-to (Huang-lian-jie-du-tang) extract on progression of carbon tetrachloride-induced acute liver injury in rats. Am. J. Chin. Med. 25: 57-68
17. Ohta, Y., Sasaki, E., Nishida, K., Kongo, M., Hayashi, T., Nagata, M., Ishiguro, I. (1998) Inhibitory effect of Oren-gedoku-to (Huan-glian-jie-du-tang) extract on hepatic triglyceride accumulation with the progression of carbon tetrachloride-induced acute liver injury in rats. J. Ethnopharmacol. 61:75-80
18. Pantoni, L., Bianchi, C., Beneke, M., Inzitari, D., Wallin, A., Erkinjuntti, T. (2000) The Scandinavian multi-infarct dementia trial: a double-blind, placebo-controlled trial on nimodipine in multi-infarct dementia. J. Neurol. Sci. 175: 116-123
19. Raman, V., Bernard, K. Stephen, S. (2006) In vitro and in vivo assessment of herb drug interactions. Life Sci. 78: 2105-2115
20. Takase, H., Inoue, O., Saito, Y., Yumioka, E., Suzuki, A. (1991a) Roles of sulfhydryl compounds in the gastric mucosal protection of the herb drugs composing oren-gedoku-to (a traditional herbal medicine). Japan. J. Pharmacol. 56: 433-439
21. Takase, H., Tatsumi, Y., Miura, O., Yumioka, E., Suzuki, A. (1991b) The mechanism of the inhibitory effects of oren-gedoku-to (OGT) on gastric acid secretion in rats. Fol. Pharmacol. Japon. 97: 97-103
22. Wang, L. M., Mineshita, S. (1996) Preventive effects of unsei-in and oren-gedoku-to, Chinese traditional medicines, against rat paw oedema and abdominal constriction in mice. J. Pharm. Pharmacol. 48: 327-331
23. Xu, J., Murakami, Y., Matsumoto, K., Tohda, M., Watanable, H., Zhang, S., Yu, Q., Shen, J. (2000) Protective effect of oren-gedoku-to (Huang-Lian-Jie-Du-Tang) against impairment of learning and memory induced by transient cerebral ischemia in mice. J. Ethnopharmacol. 73: 405-413
24. Yamasaki, K., Kajimura, K., Nakano, M., Yokoyama, H., Yoneda, K., Umezawa, C., (1998) Effects of preparations of Chinese medicinal prescriptions on digestive enzymes in vitro and in vivo. Biol. Pharm. Bull. 21: 133-139
25. Zhang, L., Liu, X., Xie, L., Wang, G. (2003) P-glycoprotein restricted transport of nimodipine across blood-brain barrier. Acta Pharmacol. Sin. 24: 903-906
26. Zhang, D., Liu, H., Xie, Liu, X (2007) Effect of baicalin and berberine on transport of nimodipine on primary cultured, rat brain microvascular endothelial cells. Acta Pharmacol. Sin. 28: 573-578