Association of methylenetetrahydrofolate reductase C677T polymorphism with genetic susceptibility to colorectal cancer

World Chinese Journal of Digestology

Volumn 15, Issue 25, 2007, Pages 2754-2757

  Jin, Xia Xiang ^a   Zhu, Zhong Zheng ^a   Wang, Ai Zhong ^a   Jia, Hang Ruo ^a  

^a No 113 Hospital of People's Liberation Army   (China)

Author keywords

Colorectal cancer; Genetic polymorphism; Genetic susceptibility; Methylenetetrahydrofolate reductase

Indexed keywords

5,10 METHYLENETETRAHYDROFOLATE REDUCTASE (FADH2);

ADENOCARCINOMA; ALCOHOL CONSUMPTION; ALLELE; ARTICLE; ASSAY; BODY MASS; CANCER GRADING; CANCER GROWTH; CANCER RISK; CANCER STAGING; CIGARETTE SMOKING; COLORECTAL CANCER; CONFIDENCE INTERVAL; CORRELATION ANALYSIS; DRINKING BEHAVIOR; FAMILY HISTORY; GENE FREQUENCY; GENETIC ASSOCIATION; GENETIC POLYMORPHISM; GENETIC RISK; GENETIC SUSCEPTIBILITY; GENOTYPE; HETEROZYGOSITY; HISTOLOGY; HOMOZYGOSITY; HUMAN; LOGISTIC REGRESSION ANALYSIS; LYMPH NODE METASTASIS; MORPHOLOGY; MULTIVARIATE ANALYSIS; RISK ASSESSMENT; RISK FACTOR; RISK REDUCTION; STATISTICAL MODEL; TUMOR LOCALIZATION; TUMOR VOLUME;

EID: 36849092819     PISSN: 10093079     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (12)

1. Brockton NT. Localized depletion: the key to colorectal cancer risk mediated by MTHFR genotype and folate? Cancer Causes Control 2006; 17: 1005-1016
2. Kono S, Chen K. Genetic polymorphisms of methyl enetetrahydrofolate reductase and colorectal cancer and adenoma. Cancer Sci 2005; 96: 535-542
3. Jiang Q, Chen K, Ma X, Li Q, Yu W, Shu G, Yao K. Diets, polymorphisms of methylenetetrahydrofolate reductase, and the susceptibility of colon cancer and rectal cancer. Cancer Detect Prev 2005; 29: 146-154
4. Chinese source
5. Chinese source
6. Chinese source
7. Chinese source
8. Halsted CH, Villanueva JA, Devlin AM, Chandler CJ. Metabolic interactions of alcohol and folate. J Nutr 2002; 132: 2367S-2372S
9. Ma J, Stampfer MJ, Giovannucci E, Artigas C, Hunter DJ, Fuchs C, Willett WC, Selhub J, Hennekens CH, Rozen R. Methylenetetrahydrofolate reductase polymorphism, dietary interactions, and risk of colorectal cancer. Cancer Res 1997; 57: 1098-1102
10. Chen J, Giovannucci E, Kelsey K, Rimm EB, Stampfer MJ, Colditz GA, Spiegelman D, Willett WC, Hunter DJ. A methylenetetrahydrofolate reductase polymorphism and the risk of colorectal cancer. Cancer Res 1996; 56: 4862-4864
11. Jakobsen A, Nielsen JN, Gyldenkerne N, Lindeberg J. Thymidylate synthase and methylenetetrahydr ofolate reductase gene polymorphism in normal tissue as predictors of fluorouracil sensitivity. J Clin Oncol 2005; 23: 1365-1369
12. Odin E, Wettergren Y, Carlsson G, Danenberg PV, Termini A, Willen R, Gustavsson B. Expression and clinical significance of methylenetetrahydrofolate reductase in patients with colorectal cancer. Clin Colorectal Cancer 2006; 5: 344-349