Longitudinal monitoring of pediatric cystic fibrosis lung disease using nitrite in exhaled breath condensate

Pediatric Pulmonology

Volumn 42, Issue 12, 2007, Pages 1198-1206

  Horak Jr , F ^a   Moeller, A ^b   Singer, F ^a   Straub, D ^b   Holler B ^a   Helbich, T H ^c   Schneider, B ^c   Eichler, I ^a   Wildhaber, J H ^f   Hall, G L ^b,d,e  

^a UNIV KLIN KINDER JUGENDHEILKUNDE   (Austria)

^b UNIVERSITY CHILDREN S HOSPITAL   (Switzerland)

^c MEDICAL UNIVERSITY OF VIENNA   (Austria)

^d PRINCESS MARGARET HOSPITAL FOR CHILDREN   (Australia)

^e UNIVERSITY OF WESTERN AUSTRALIA   (Australia)

^f NONE   (Switzerland)

Author keywords

CF; Children; Exhaled breath condensate; Longitudinal; Monitoring; NO metabolites

Indexed keywords

NITRATE;

ADOLESCENT; ADULT; ARTICLE; BACTERIUM CULTURE; CHILD; CLINICAL ASSESSMENT; CONTROLLED STUDY; CORRELATION ANALYSIS; CYSTIC FIBROSIS; DISEASE ACTIVITY; DISEASE EXACERBATION; EXHALED BREATH CONDENSATE; FOLLOW UP; HUMAN; LONGITUDINAL STUDY; LUNG DISEASE; NON INVASIVE PROCEDURE; PREDICTION; PRIORITY JOURNAL; RESPIRATORY TRACT INFLAMMATION; SPIROMETRY; SPUTUM CULTURE; THORAX RADIOGRAPHY; THROAT CULTURE;

ADOLESCENT; ADULT; BREATH TESTS; CHILD; CYSTIC FIBROSIS; EXHALATION; FOLLOW-UP STUDIES; HUMANS; LUNG DISEASES; NITRIC OXIDE; PROGNOSIS; RADIOGRAPHY, THORACIC; SEVERITY OF ILLNESS INDEX;

EID: 36849078125     PISSN: 87556863     EISSN: 10990496     Source Type: Journal    
DOI: 10.1002/ppul.20719     Document Type: Article

References (41)

1. Armstrong DS, Grimwood K, Carlin JB, Carzino R, Gutierrez JP, Hull J, Olinsky A, Phelan EM, Robertson CF, Phelan PD. Lower airway inflammation in infants and young children with cystic fibrosis. Am J Respir Crit Care Med 1997; 156:1197-1204.
2. Balough K, McCubbin M, Weinberger M, Smits W, Ahrens R, Fick R. The relationship between infection and inflammation in the early stages of lung disease from cystic fibrosis. Pediatr Pulmonol 1995;20:63-70.
3. Dakin CJ, Numa AH, Wang H, Morton JR, Vertzyas CC, Henry RL. Inflammation, infection and pulmonary function in infants and young children with cystic fibrosis. Am J Respir Crit Care Med 2002;165:904-910.
4. Narang I, Ersu R, Wilson NM, Bush A. Nitric oxide in chronic airway inflammation in children: diagnostic use and pathophysiological significance. Thorax 2002;57:586-589.
5. Jobsis Q, Raatgeep HC, Schellekens SL, Kroesbergen A, Hop WC, de Jongste JC. Hydrogen peroxide and nitric oxide in exhaled air of children with cystic fibrosis during antibiotic treatment. Eur Respir J 2000;16:95-100.
6. Ho LP, Innes JA, Greening AP. Exhaled nitric oxide is not elevated in the inflammatory airways diseases of cystic fibrosis and bronchiectasis. Eur Respir J 1998;12:1290-1294.
7. Ojoo JC, Mulrennan SA, Kastelik JA, Morice AH, Redington AE. Exhaled breath condensate pH and exhaled nitric oxide in allergic asthma and in cystic fibrosis. Thorax 2005;60:22-26.
8. Brennan S, Hall GL, Horak F jr, Moeller A, Pitrez PMC, Franzmann A, et al. Correlation of forced oscillation technique in preschool children with cystic fibrosis with pulmonary inflammation. Thorax 2005;60:159-163.
9. Ho LP, Innes JA, Greening AP. Nitrite levels in breath condensate of patients with cystic fibrosis is elevated in contrast to exhaled nitric oxide. Thorax 1998;53:680-684.
10. Formanek W, Inci D, Lauener RP, Wildhaber JH, Frey U, Hall GL. Elevated nitrite in breath condensates of children with respiratory disease. Eur Respir J 2002;19:487-491.
11. Cunningham S, McColm JR, Ho LP, Greening AP, Marshall TG. Measurement of inflammatory markers in the breath condensate of children with cystic fibrosis. Eur Respir J 2000;15:955-957.
12. Jones KL, Hegab AH, Hillman BC, Simpson KL, Jinkins PA, Grisham MB, Owens MW, Sato E, Robbins RA. Elevation of nitrotyrosine and nitrate concentrations in cystic fibrosis sputum. Pediatr Pulmonol 2000;30:79-85.
13. Meng QH, Polak JM, Edgar AJ, Chacon MR, Evans TJ, Gruenert DC, Bishop AE. Neutrophils enhance expression of inducible nitric oxide synthase in human normal but not cystic fibrosis bronchial epithelial cells. J Pathol 2000;190:126-132.
14. Morrissey BM, Schilling K, Weil JV, Silkoff PE, Rodman DM. Nitric oxide and protein nitration in the cystic fibrosis airway. Arch Biochem Biophys 2002;406:33-39.
15. Moeller A, Horak F Jr, Lane C, Knight D, Kicic A, Brennan S, Franklin P, Terpolilli J, Wildhaber JH, Stick S. Inducible NO synthase expression is low in airway epithelium from young children with cystic fibrosis. Thorax 2006;61:514-520.
16. American Thoracic Society. Standardization of spirometry 1994 update. Am J Respir Crit Care Med 1995;152:1107-1136.
17. Zapletal A, Samanek M, Paul T. Lung function in children and adolescents: methods and reference values. Prog Respir Res 1987;22:113-218.
18. Chrispin AR, Norman AP. The systematic evaluation of a chest radiograph in CF. Pediatr Radiol 1974;2:101-106.
19. Rosenecker J, Eichler I, Barmeier H, von der Hardt H. Diabetes mellitus and cystic fibrosis: comparison of clinical parameters in patients treated with insulin versus oral glucose-lowering agents. Pediatr Pulmonol 2001;32:351-355.
20. Shwachman H, Kulczycki LL. Long term study of 105 patients with CF. Am J Dis Child 1958;96:6-15.
21. Franklin P, Moeller A, Hall GL, Horak F Jr, Patterson H, Stick SM. Variability of nitric oxide metabolites in exhaled breath condensate. Respir Med 2006;100:123-129.
22. Green LC, Wagner DA, Glogowski J, Skipper PL, Wishnok JS, Tannenbaum SR. Analysis of nitrate, nitrite and 15N nitrate in biological fluids. Anal Biochem 1982;126:131-138.
23. Silkoff PE, Erzurum SC, Lundberg JO, George SC, Marczin N, Hunt JF, Effros Horvath I, American Thoracic Society, HOC Subcommittee of the Assembly on Allergy. Immunology, and inflammation. ATS workshop proceedings: exhaled nitric oxide and nitric oxide oxidative metabolism in exhaled breath condensate. Proc Am Thorac Soc 2006;3:131-145
24. and Am J of Respir Crit Care Med 2006;173:811-813.
25. Rosias PP, Dompeling E, Hendriks HJ, Heijnens JW, Donckerwolcke RA, Jobsis Q. Exhaled breath condensate in children: pearls and pitfalls. Pediatr Allergy Immunol 2004;15:4-19.
26. Straub DA, Minocchieri S, Moeller A, Hamacher J, Wildhaber JH. The effect of montelukast on exhaled nitric oxide and lung function in asthmatic children 2 to 5 years old. Chest 2005;127:509-514.
27. Carpagno GE, Barnes PJ, Geddes DM, Hodson ME, Kharitonov SA. Increased leukotriene B4 and interleukin-6 in exhaled breath condensate in cystic fibrosis. Am J Resp Crit Care Med 2003;167:1109-1112.
28. Zacharasiewicz A, Wilson N, Lex C, Erin EM, Li AM, Hansel T, Khan M, Bush A. Clinical use of noninvasive measurements of airway inflammation in steroid reduction in children. Am J Respir Crit Care Med 2005;15:1077-1082.
29. Terheggen-Lagro S, Truijens N, van Poppel N, Gulmans V, van der Laag J, van der Ent C. Correlation of six different cystic fibrosis chest radiograph scoring systems with clinical parameters. Pediatr Pulmonol 2003;35:441-445.
30. Tate S, MacGregor G, Davis M, Innes JA, Greenin AP. Airways in cystic fibrosis are acidified: detection by exhaled breath condensate. Thorax 2002;57:926-929.
31. Hunt J. Exhaled breath condensate: an evolving tool for noninvasive evaluation of lung disease. J Allergy Clin Immunol 2002;110:28-34.
32. Cetin I, Özcelik U, Göcmen A, Kiper N, Dogru D, Yalcin E. BALF nitrite as an indicator of inflammation in children with CF. Respiration 2004;71:625-629.
33. Gessner AR, Mortensen JE. Pathogenic factors of Pseudomonas cepacia isolates from patients with cystic fibrosis. J Med Microbiol 1990;33:115-120.
34. Yoon SS, Hennigan EF, Hillard GM, Ochsner UA, Parvatiyar K, Kamani MC, Allen HL, DeKievit TR, Gardner PR, Schwab U, Rowe JJ, Iglewski BH, McDermott TR, Mason RP, Wozniak DJ, Hancock RE, Parsek MR, Noah TL, Boucher RC, Hassett DJ. Pseudomonas aeruginosa anaerobic respiration in biofilms: relationship to cystic fibrosis pathogenesis. Dev Cell 2002;3:593-603.
35. Gaston B, Ratjen F, Vaughan JW, Malhotra NR, Canady RG, Snyder AH, Hunt JF, Gaertig S, Goldberg JB. Nitrogen redox balance in the cystic fibrosis airway: effects of antipseudomonal therapy. Am J Respir Crit Care Med 2002;165:387-390.
36. Hunt JF, Fang K, Malik R, Snyder A, Malhotra N, Platts-Mills TA, Gaston B. Endogenous airway acidification: implications for asthma pathophysiology. Am J Respir Crit Care Med 2000;161:694-699.
37. Effros RM, Hoagland KW, Bosbous M, Castillo D, Foss B, Dunning M, Gare M, Lin W, Sun F. Dilution of respiratory solutes in exhaled condensates. Am J Respir Crit Care Med 2002;165:663-669.
38. Effros RM, Biller J, Foss B, Hoagland K, Dunning MB, Castillo D, Bosbous M, Sun F, Shaker R. A simple method for estimating respiratory solute dilution in exhaled breath condensates. Am J Respir Crit Care Med 2003;168:1500-1505.
39. Hull J, Skinner W, Robertson C, Phelan P. Elemental content of airway surface liquid from infants with cystic fibrosis. Am J Respir Crit Care Med 1998;157:10-14.
40. Halmerbauer G, Arri S, Schierl M, Strauch E, Koller DY. The relationship between eosinophil granule proteins to ions in the sputum of patients with cystic fibrosis. Clin Exp Allergy 2000;30:1771-1776.
41. Gaston B, Drazen J, Loscalzo J, Stamler JS. The biology of NO in the airways. Am J Respir Crit Care Med 1994;149:538-551.