Targeted disruption of homoserine dehydrogenase gene and its effect on cephamycin C production in Streptomyces clavuligerus

Journal of Industrial Microbiology and Biotechnology

Volumn 35, Issue 1, 2008, Pages 1-7

  Yilmaz, Ebru I ^a,b   Çaydasi, Ayse K ^a   Özcengiz, Gülay ^a  

^a MIDDLE EAST TECHNICAL UNIVERSITY   (Turkey)

^b DICLE UNIVERSITY   (Turkey)

Author keywords

Aspartate pathway; Cephamycin C; Gene disruption; Homoserine dehydrogenase; Streptomyces clavuligerus

Indexed keywords

AMINO ACID; ANTIBIOTIC AGENT; CEPHALOSPORIN C; CEPHAMYCIN C; HOMOSERINE DEHYDROGENASE; LYSINE; RECOMBINANT PROTEIN;

AMINO ACID COMPOSITION; ARTICLE; AUXOTROPHIC MUTANT; BACTERIAL GENE; BACTERIAL STRAIN; BIOSYNTHESIS; CONTROLLED STUDY; DRUG MANUFACTURE; ENZYME PURIFICATION; ESCHERICHIA COLI; GENE CASSETTE; GENE CONSTRUCT; GENE DISRUPTION; GENE INACTIVATION; GENE INSERTION; GENE TARGETING; GENETIC TRANSFORMATION; HETEROLOGOUS EXPRESSION; MOLECULAR CLONING; NONHUMAN; OPEN READING FRAME; PLASMID; STREPTOMYCES CLAVULIGERUS;

ANTI-BACTERIAL AGENTS; CEPHAMYCINS; CLONING, MOLECULAR; CULTURE MEDIA; ESCHERICHIA COLI; GENE EXPRESSION REGULATION, BACTERIAL; GENE SILENCING; HOMOSERINE DEHYDROGENASE; INDUSTRIAL MICROBIOLOGY; RECOMBINANT PROTEINS; STREPTOMYCES;

ESCHERICHIA COLI; STREPTOMYCES CLAVULIGERUS;

EID: 36849053355     PISSN: 13675435     EISSN: 14765535     Source Type: Journal    
DOI: 10.1007/s10295-007-0259-8     Document Type: Article

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