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Volumn 72, Issue 25, 2007, Pages 9491-9500

A novel approach to the synthesis of DNA and RNA lariats

Author keywords

[No Author keywords available]

Indexed keywords

BIOSYNTHESIS; HYDROLYSIS; MASS SPECTROMETRY; POLYAMIDES; POLYESTERS; RNA;

EID: 36849040522     PISSN: 00223263     EISSN: None     Source Type: Journal    
DOI: 10.1021/jo701418w     Document Type: Article
Times cited : (10)

References (66)
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    • Gendron, D.; Carriero, S.; Garneau, D.; Villemaire, J.; Klinck, R.; Abou, Elela, S.; Damha, M. J.; Chabot, B. BMC Biotechnol. 2006, 6, 1-12.
    • Gendron, D.; Carriero, S.; Garneau, D.; Villemaire, J.; Klinck, R.; Abou, Elela, S.; Damha, M. J.; Chabot, B. BMC Biotechnol. 2006, 6, 1-12.
  • 19
    • 0028134833 scopus 로고    scopus 로고
    • Nilsson, M.; Malmgren, H.; Samiotaki, Kwiatkowski, M. M.; Chowdhary, B. P.; Landegren, U. Science. 1994, 265, 2085-2088.
    • Nilsson, M.; Malmgren, H.; Samiotaki, Kwiatkowski, M. M.; Chowdhary, B. P.; Landegren, U. Science. 1994, 265, 2085-2088.
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    • 36849054431 scopus 로고    scopus 로고
    • Manuscript in preparation
    • Mitra, D.; Damha, M. J. Manuscript in preparation.
    • Mitra, D.1    Damha, M.J.2
  • 38
    • 36849055004 scopus 로고    scopus 로고
    • Attempted synthesis of 1b:4 with the RNA template, showing biphasic thermal denaturation curve in the nicked form, resulted in a 30% yield of 1c. The increase in product yield may be indicative of a stronger cooperative trend upon association to the RNA template. In general, however, the poor yields of 1c observed vs 2c may be the result of the inherent chemical ligation capability or efficiency of the CNBr reagent in the preferential formation rA internucleotide phosphodiester bonds vs that of rU.
    • Attempted synthesis of 1b:4 with the RNA template, showing biphasic thermal denaturation curve in the nicked form, resulted in a 30% yield of 1c. The increase in product yield may be indicative of a stronger cooperative trend upon association to the RNA template. In general, however, the poor yields of 1c observed vs 2c may be the result of the inherent chemical ligation capability or efficiency of the CNBr reagent in the preferential formation rA internucleotide phosphodiester bonds vs that of rU.
  • 41
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    • (1995)
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    • (1999)
    • Braich, R.S.1
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    • Chu, Vi, T.; Adamidi, C.; Liu, Q.; Perlman, P. S.; Pyle, A. M. EMBO 2001, 20, 6866-6876.
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* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.