메뉴 건너뛰기




Volumn 9, Issue 5, 2007, Pages 415-421

Renin inhibitors: Optimal strategy for renal protection

Author keywords

[No Author keywords available]

Indexed keywords

ALISKIREN; AMLODIPINE; ANGIOTENSIN 2 RECEPTOR ANTAGONIST; ANGIOTENSIN RECEPTOR ANTAGONIST; CALCIUM CHANNEL BLOCKING AGENT; CANDESARTAN; CAPTOPRIL; DIPEPTIDYL CARBOXYPEPTIDASE INHIBITOR; DIURETIC AGENT; ENALKIREN; IRBESARTAN; KIDNEY RENIN; LISINOPRIL; LOSARTAN; PLACEBO; REMIKIREN; RENIN INHIBITOR; TRANDOLAPRIL; VALSARTAN;

EID: 36849037315     PISSN: 15226417     EISSN: None     Source Type: Journal    
DOI: 10.1007/s11906-007-0076-5     Document Type: Review
Times cited : (6)

References (55)
  • 1
    • 36849030110 scopus 로고    scopus 로고
    • National Kidney Foundation:, Available at:, Accessed November 16, 2006
    • National Kidney Foundation: Kidney disease. Available at: http://www.kidney.org/kidneyDisease/. Accessed November 16, 2006.
    • Kidney disease
  • 2
    • 36849010009 scopus 로고    scopus 로고
    • US Renal Data System: USRDS 2006 Annual Data Report: Atlas of End-Stage Renal Disease in the United States. Bethesda, MD: National Institutes of Health, National Institute of Diabetes and Digestive and Kidney Diseases; 2006.
    • US Renal Data System: USRDS 2006 Annual Data Report: Atlas of End-Stage Renal Disease in the United States. Bethesda, MD: National Institutes of Health, National Institute of Diabetes and Digestive and Kidney Diseases; 2006.
  • 3
    • 0038460302 scopus 로고    scopus 로고
    • The Seventh Report of the Joint National Committee on Prevention, Detection, Evaluation, and Treatment of High Blood Pressure: The JNC 7 report
    • Chobanian AV, Bakris GL, Black HR, et al.: The Seventh Report of the Joint National Committee on Prevention, Detection, Evaluation, and Treatment of High Blood Pressure: the JNC 7 report. JAMA 2003, 289:2560-2572.
    • (2003) JAMA , vol.289 , pp. 2560-2572
    • Chobanian, A.V.1    Bakris, G.L.2    Black, H.R.3
  • 4
    • 0034627183 scopus 로고    scopus 로고
    • Effects of ACE inhibitors, calcium antagonists, and other blood-pressure-lowering drugs: Results of prospectively designed overviews of randomised trials. Blood Pressure Lowering Treatment Trialists' Collaboration
    • Neal B, MacMahon S, Chapman N, et al.: Effects of ACE inhibitors, calcium antagonists, and other blood-pressure-lowering drugs: results of prospectively designed overviews of randomised trials. Blood Pressure Lowering Treatment Trialists' Collaboration. Lancet 2000, 356:1955-1964.
    • (2000) Lancet , vol.356 , pp. 1955-1964
    • Neal, B.1    MacMahon, S.2    Chapman, N.3
  • 5
    • 42749099562 scopus 로고    scopus 로고
    • Angiotensin-converting enzyme inhibitors and angiotensin II receptor antagonists for preventing the progression of diabetic kidney disease
    • CD006257
    • Strippoli GF, Bonifati C, Craig M, et al.: Angiotensin-converting enzyme inhibitors and angiotensin II receptor antagonists for preventing the progression of diabetic kidney disease. Cochrane Database Syst Rev 2006, (4):CD006257.
    • (2006) Cochrane Database Syst Rev , Issue.4
    • Strippoli, G.F.1    Bonifati, C.2    Craig, M.3
  • 6
    • 0037667643 scopus 로고    scopus 로고
    • Newly recognized components of the renin-angiotensin system: Potential roles in cardiovascular and renal regulation
    • Carey RM, Siragy HM: Newly recognized components of the renin-angiotensin system: potential roles in cardiovascular and renal regulation. Endocr Rev 2003, 24:261-271.
    • (2003) Endocr Rev , vol.24 , pp. 261-271
    • Carey, R.M.1    Siragy, H.M.2
  • 7
    • 0037527730 scopus 로고    scopus 로고
    • Angiotensin AT1/AT2 receptors: Regulation, signalling and function
    • Kaschina E, Unger T: Angiotensin AT1/AT2 receptors: regulation, signalling and function. Blood Press 2003, 12:70-88.
    • (2003) Blood Press , vol.12 , pp. 70-88
    • Kaschina, E.1    Unger, T.2
  • 8
    • 0038506851 scopus 로고    scopus 로고
    • The renin-angiotensin-aldosterone system: Cardiorenal effects and implications for renal and cardiovascular disease states
    • Brewster UC, Setaro JF, Perazella MA: The renin-angiotensin-aldosterone system: cardiorenal effects and implications for renal and cardiovascular disease states. Am J Med Sci 2003, 326:15-24.
    • (2003) Am J Med Sci , vol.326 , pp. 15-24
    • Brewster, U.C.1    Setaro, J.F.2    Perazella, M.A.3
  • 9
    • 7944222897 scopus 로고    scopus 로고
    • The role of the renin-angiotensin-aldosterone system in diabetes and its vascular complications
    • Cooper ME: The role of the renin-angiotensin-aldosterone system in diabetes and its vascular complications. Am J Hypertens 2004, 17:16S-20S.
    • (2004) Am J Hypertens , vol.17
    • Cooper, M.E.1
  • 10
    • 0036209899 scopus 로고    scopus 로고
    • ACE inhibitors versus AT(1) receptor antagonists in patients with chronic renal disease
    • Hilgers KF, Mann JF: ACE inhibitors versus AT(1) receptor antagonists in patients with chronic renal disease. J Am Soc Nephrol 2002, 13:1100-1108.
    • (2002) J Am Soc Nephrol , vol.13 , pp. 1100-1108
    • Hilgers, K.F.1    Mann, J.F.2
  • 11
    • 18844366399 scopus 로고    scopus 로고
    • Mechanisms for the clinical benefits of angiotensin II receptor blockers
    • Schmieder RE: Mechanisms for the clinical benefits of angiotensin II receptor blockers. Am J Hypertens 2005, 18:720-730.
    • (2005) Am J Hypertens , vol.18 , pp. 720-730
    • Schmieder, R.E.1
  • 12
    • 17144469021 scopus 로고    scopus 로고
    • Renin-angiotensin system activation and interstitial inflammation in human diabetic nephropathy
    • Mezzano S, Droguett A, Burgos ME, et al.: Renin-angiotensin system activation and interstitial inflammation in human diabetic nephropathy. Kidney Int Suppl 2003, 86:S64-70.
    • (2003) Kidney Int Suppl , vol.86
    • Mezzano, S.1    Droguett, A.2    Burgos, M.E.3
  • 14
    • 0037213761 scopus 로고    scopus 로고
    • Glomerular hemodynamics and the renin-angiotensin system in patients with type 1 diabetes mellitus
    • Hollenberg NK, Price DA, Fisher ND, et al.: Glomerular hemodynamics and the renin-angiotensin system in patients with type 1 diabetes mellitus. Kidney Int 2003, 63:172-178.
    • (2003) Kidney Int , vol.63 , pp. 172-178
    • Hollenberg, N.K.1    Price, D.A.2    Fisher, N.D.3
  • 16
    • 0031733560 scopus 로고    scopus 로고
    • Angiotensin II is involved in the progression of renal disease: Importance of non-hemodynamic mechanisms
    • Wolf G: Angiotensin II is involved in the progression of renal disease: importance of non-hemodynamic mechanisms. Nephrologie 1998, 19:451-456.
    • (1998) Nephrologie , vol.19 , pp. 451-456
    • Wolf, G.1
  • 17
    • 34250353444 scopus 로고    scopus 로고
    • The potential role of prorenin in diabetic nephropathy
    • Schmieder RE: The potential role of prorenin in diabetic nephropathy. J Hypertens 2067, 25:1323-1326.
    • (2067) J Hypertens , Issue.25 , pp. 1323-1326
    • Schmieder, R.E.1
  • 18
    • 31944446459 scopus 로고    scopus 로고
    • The continuing saga of the AT2 receptor: A case of the good, the bad, and the innocuous
    • Reudelhuber TL: The continuing saga of the AT2 receptor: a case of the good, the bad, and the innocuous. Hypertension 2005, 46:1261-1262.
    • (2005) Hypertension , vol.46 , pp. 1261-1262
    • Reudelhuber, T.L.1
  • 19
    • 0030604561 scopus 로고    scopus 로고
    • Randomised placebo-controlled trial of effect of ramipril on decline in glomerular filtration rate and risk of terminal renal failure in proteinuric, non-diabetic nephropathy
    • The GISEN Group Gruppo Italiano di Studi Epidemiologici in Nefrologia
    • The GISEN Group (Gruppo Italiano di Studi Epidemiologici in Nefrologia): Randomised placebo-controlled trial of effect of ramipril on decline in glomerular filtration rate and risk of terminal renal failure in proteinuric, non-diabetic nephropathy. Lancet 1997, 349:1857-1863.
    • (1997) Lancet , vol.349 , pp. 1857-1863
  • 20
    • 0035922441 scopus 로고    scopus 로고
    • Effects of losartan on renal and cardiovascular outcomes in patients with type 2 diabetes and nephropathy
    • Brenner BM, Cooper ME, de Zeeuw D, et al.: Effects of losartan on renal and cardiovascular outcomes in patients with type 2 diabetes and nephropathy. N Engl J Med 2001, 345:861-869.
    • (2001) N Engl J Med , vol.345 , pp. 861-869
    • Brenner, B.M.1    Cooper, M.E.2    de Zeeuw, D.3
  • 21
    • 0035922447 scopus 로고    scopus 로고
    • Renoprotective effect of the angiotensin-receptor antagonist irbesartan in patients with nephropathy due to type 2 diabetes
    • Lewis EJ, Hunsicker LG, Clarke WR, et al.: Renoprotective effect of the angiotensin-receptor antagonist irbesartan in patients with nephropathy due to type 2 diabetes. N Engl J Med 2001, 345:851-860.
    • (2001) N Engl J Med , vol.345 , pp. 851-860
    • Lewis, E.J.1    Hunsicker, L.G.2    Clarke, W.R.3
  • 22
    • 33644912981 scopus 로고    scopus 로고
    • Independent and additive impact of blood pressure control and angiotensin II receptor blockade on renal outcomes in the irbesartan diabetic nephropathy trial: Clinical implications and limitations
    • Pohl MA, Blumenthal S, Cordonnier DJ, et al.: Independent and additive impact of blood pressure control and angiotensin II receptor blockade on renal outcomes in the irbesartan diabetic nephropathy trial: clinical implications and limitations. J Am Soc Nephrol 2005, 16:3027-3037.
    • (2005) J Am Soc Nephrol , vol.16 , pp. 3027-3037
    • Pohl, M.A.1    Blumenthal, S.2    Cordonnier, D.J.3
  • 23
    • 33746166863 scopus 로고    scopus 로고
    • Inhibiting the renin-angiotensin system to prevent cardiovascular diseases: Do we need a more comprehensive strategy?
    • Weber MA, Giles TD: Inhibiting the renin-angiotensin system to prevent cardiovascular diseases: do we need a more comprehensive strategy? Rev Cardiovasc Med 2006, 7:45-54.
    • (2006) Rev Cardiovasc Med , vol.7 , pp. 45-54
    • Weber, M.A.1    Giles, T.D.2
  • 24
    • 30944466929 scopus 로고    scopus 로고
    • Enhanced renoprotective effects of ultrahigh doses of irbesartan in patients with type 2 diabetes and microalbuminuria
    • Rossing K, Schjoedt KJ, Jensen BR, et al.: Enhanced renoprotective effects of ultrahigh doses of irbesartan in patients with type 2 diabetes and microalbuminuria. Kidney Int 2005, 68:1190-1198.
    • (2005) Kidney Int , vol.68 , pp. 1190-1198
    • Rossing, K.1    Schjoedt, K.J.2    Jensen, B.R.3
  • 25
    • 0037431774 scopus 로고    scopus 로고
    • Combination treatment of angiotensin-II receptor blocker and angiotensin-converting-enzyme inhibitor in non-diabetic renal disease (COOPERATE): A randomised controlled trial
    • Nakao N, Yoshimura A, Morita H, et al.: Combination treatment of angiotensin-II receptor blocker and angiotensin-converting-enzyme inhibitor in non-diabetic renal disease (COOPERATE): a randomised controlled trial. Lancet 2003, 361:117-124,
    • (2003) Lancet , vol.361 , pp. 117-124
    • Nakao, N.1    Yoshimura, A.2    Morita, H.3
  • 26
    • 0034627208 scopus 로고    scopus 로고
    • Randomised controlled trial of dual blockade of renin-angiotensin system in patients with hypertension, microalbuminuria, and non-insulin dependent diabetes: The candesartan and lisinopril microalbuminuria (CALM) study
    • Mogensen CE, Neldam S, Tikkanen I, et al.: Randomised controlled trial of dual blockade of renin-angiotensin system in patients with hypertension, microalbuminuria, and non-insulin dependent diabetes: the candesartan and lisinopril microalbuminuria (CALM) study. BMJ 2000, 321:1440-1444.
    • (2000) BMJ , vol.321 , pp. 1440-1444
    • Mogensen, C.E.1    Neldam, S.2    Tikkanen, I.3
  • 27
    • 33645060064 scopus 로고    scopus 로고
    • Additional antiproteinuric effect of ultrahigh-dose candesartan: A double-blind, randomized, prospective study
    • Schmieder RE, Klingbeil AU, Fleischmann EH, et al.: Additional antiproteinuric effect of ultrahigh-dose candesartan: a double-blind, randomized, prospective study. J Am Soc Nephrol 2005, 16:3038-3045.
    • (2005) J Am Soc Nephrol , vol.16 , pp. 3038-3045
    • Schmieder, R.E.1    Klingbeil, A.U.2    Fleischmann, E.H.3
  • 28
    • 0346895374 scopus 로고    scopus 로고
    • Therapeutic potential of renin inhibitors in the management of cardiovascular disorders
    • Stanton A: Therapeutic potential of renin inhibitors in the management of cardiovascular disorders. Am J Cardiovasc Drugs 2003, 3:389-394.
    • (2003) Am J Cardiovasc Drugs , vol.3 , pp. 389-394
    • Stanton, A.1
  • 29
    • 0042661157 scopus 로고    scopus 로고
    • Structure-based design of aliskiren, a novel orally effective renin inhibitor
    • Wood JM, Maibaum J, Rahuel J, et al.: Structure-based design of aliskiren, a novel orally effective renin inhibitor. Biochem Biophys Res Commun 2003, 308:698-705.
    • (2003) Biochem Biophys Res Commun , vol.308 , pp. 698-705
    • Wood, J.M.1    Maibaum, J.2    Rahuel, J.3
  • 30
    • 34548087645 scopus 로고    scopus 로고
    • Aliskiren, a novel renin inhibitor, provides long-term suppression of the renin system, when used alone or in combination with hydrochlorothiazide in the treatment of hypertension
    • Pool J, Gradman A, Kolloch R, et al.: Aliskiren, a novel renin inhibitor, provides long-term suppression of the renin system, when used alone or in combination with hydrochlorothiazide in the treatment of hypertension. Eur Heart J 2006, 27:119.
    • (2006) Eur Heart J , vol.27 , pp. 119
    • Pool, J.1    Gradman, A.2    Kolloch, R.3
  • 31
    • 33947197776 scopus 로고    scopus 로고
    • Aliskiren, a novel renin inhibitor for treatment of hypertension, enhances renin system suppression by reducing plasma renin activity alone or in combination with ramipril in patients with diabetes
    • Kilo C, Taylor A, Tschoepe D, et al.: Aliskiren, a novel renin inhibitor for treatment of hypertension, enhances renin system suppression by reducing plasma renin activity alone or in combination with ramipril in patients with diabetes. Eur Heart J 2006, 27:118-119.
    • (2006) Eur Heart J , vol.27 , pp. 118-119
    • Kilo, C.1    Taylor, A.2    Tschoepe, D.3
  • 32
    • 9644287897 scopus 로고    scopus 로고
    • Pharmacologic demonstration of the synergistic effects of a combination of the renin inhibitor aliskiren and the AT1 receptor antagonist valsartan on the angiotensin II-renin feedback interruption
    • Azizi M, Menard J, Bissery A, et al.: Pharmacologic demonstration of the synergistic effects of a combination of the renin inhibitor aliskiren and the AT1 receptor antagonist valsartan on the angiotensin II-renin feedback interruption. J Am Soc Nephrol 2004, 15:3126-3133.
    • (2004) J Am Soc Nephrol , vol.15 , pp. 3126-3133
    • Azizi, M.1    Menard, J.2    Bissery, A.3
  • 33
    • 0036266596 scopus 로고    scopus 로고
    • Pivotal role of the renin/ prorenin receptor in angiotensin II production and cellular responses to renin
    • Nguyen G, Delarue F, Burckle C, et al.: Pivotal role of the renin/ prorenin receptor in angiotensin II production and cellular responses to renin. J Clin Invest 2002, 109:1417-1427.
    • (2002) J Clin Invest , vol.109 , pp. 1417-1427
    • Nguyen, G.1    Delarue, F.2    Burckle, C.3
  • 34
    • 33644789557 scopus 로고    scopus 로고
    • Renin inhibition with aliskiren: Where are we now, and where are we going?
    • Azizi M, Webb R, Nussberger J, Hollenberg NK: Renin inhibition with aliskiren: where are we now, and where are we going? J Hypertens 2006, 24:243-256.
    • (2006) J Hypertens , vol.24 , pp. 243-256
    • Azizi, M.1    Webb, R.2    Nussberger, J.3    Hollenberg, N.K.4
  • 35
    • 0023635830 scopus 로고
    • Clinical and biochemical effects of the renin inhibitor H142 in humans
    • Webb DJ, Manhem PJ, Bali SG, et al.: Clinical and biochemical effects of the renin inhibitor H142 in humans. J Cardiovasc Pharmacol 1987, 10:S69-74.
    • (1987) J Cardiovasc Pharmacol , vol.10
    • Webb, D.J.1    Manhem, P.J.2    Bali, S.G.3
  • 36
    • 0028299990 scopus 로고
    • R-PEP-27, a potent renin inhibitor, decreases plasma angiotensin II and blood pressure in normal volunteers
    • Zusman RM, Hui KY, Nussberger J, et al.: R-PEP-27, a potent renin inhibitor, decreases plasma angiotensin II and blood pressure in normal volunteers. Am J Hypertens 1994, 7:295-301.
    • (1994) Am J Hypertens , vol.7 , pp. 295-301
    • Zusman, R.M.1    Hui, K.Y.2    Nussberger, J.3
  • 37
    • 0028895715 scopus 로고
    • Dose-dependent effects of the renin inhibitor zankiren HCI after a single oral dose in mildly sodium-depleted normotensive subjects
    • Menard J, Boger RS, Moyse DM, et al.: Dose-dependent effects of the renin inhibitor zankiren HCI after a single oral dose in mildly sodium-depleted normotensive subjects. Circulation 1995, 91:330-338.
    • (1995) Circulation , vol.91 , pp. 330-338
    • Menard, J.1    Boger, R.S.2    Moyse, D.M.3
  • 38
    • 0028210554 scopus 로고
    • Blood pressure effects of acute intravenous renin or oral angiotensin converting enzyme inhibition in essential hypertension
    • Azizi M, Guyene TT, Chatellier G, Menard J: Blood pressure effects of acute intravenous renin or oral angiotensin converting enzyme inhibition in essential hypertension. J Hypertens 1994, 12:419-427.
    • (1994) J Hypertens , vol.12 , pp. 419-427
    • Azizi, M.1    Guyene, T.T.2    Chatellier, G.3    Menard, J.4
  • 39
    • 0026010191 scopus 로고
    • Immediate blood pressure effects of the renin inhibitor enalkiren and the angiotensin-converting enzyme inhibitor enalaprilat
    • Neutel JM, Luther RR, Boger RS, Weber MA: Immediate blood pressure effects of the renin inhibitor enalkiren and the angiotensin-converting enzyme inhibitor enalaprilat. Am Heart J 1991, 122:1094-1100.
    • (1991) Am Heart J , vol.122 , pp. 1094-1100
    • Neutel, J.M.1    Luther, R.R.2    Boger, R.S.3    Weber, M.A.4
  • 40
    • 33745748133 scopus 로고    scopus 로고
    • Aliskiren, an oral renin inhibitor, provides dose-dependent efficacy and placebo-like tolerability in patients with hypertension
    • Oh B-H, Chung J, Khan M, et al.: Aliskiren, an oral renin inhibitor, provides dose-dependent efficacy and placebo-like tolerability in patients with hypertension. J Am Coll Cardiol 2006, 47:370A.
    • (2006) J Am Coll Cardiol , vol.47
    • Oh, B.-H.1    Chung, J.2    Khan, M.3
  • 41
    • 14844363404 scopus 로고    scopus 로고
    • Aliskiren, a novel orally effective renin inhibitor, provides dose-dependent antihypertensive efficacy and placebo-like tolerability in hypertensive patients
    • Gradman AH, Schmieder RE, Lins RL, et al.: Aliskiren, a novel orally effective renin inhibitor, provides dose-dependent antihypertensive efficacy and placebo-like tolerability in hypertensive patients. Circulation 2005, 111:1012-1018.
    • (2005) Circulation , vol.111 , pp. 1012-1018
    • Gradman, A.H.1    Schmieder, R.E.2    Lins, R.L.3
  • 42
    • 33845329332 scopus 로고    scopus 로고
    • Antihypertensive efficacy and safety of the oral renin inhibitor aliskiren in patients with hypertension: A pooled analysis
    • Weir MR, Bush C, Zhang J, et al.: Antihypertensive efficacy and safety of the oral renin inhibitor aliskiren in patients with hypertension: a pooled analysis. Eur Heart J 2006, 27:299.
    • (2006) Eur Heart J , vol.27 , pp. 299
    • Weir, M.R.1    Bush, C.2    Zhang, J.3
  • 43
    • 34548014546 scopus 로고    scopus 로고
    • The oral renin inhibitor aliskiren has comparable safety and efficacy to lisinopril in patients with severe hypertension
    • Strasser RH, Puig JG, Farsang C, et al.: The oral renin inhibitor aliskiren has comparable safety and efficacy to lisinopril in patients with severe hypertension. J Hypertens 2006, 24:99-100.
    • (2006) J Hypertens , vol.24 , pp. 99-100
    • Strasser, R.H.1    Puig, J.G.2    Farsang, C.3
  • 44
    • 33749847756 scopus 로고    scopus 로고
    • Aliskiren, a novel renin inhibitor, has greater BP lowering than ramipril and additional BP lowering when combined with ramipril in patients with diabetes and hypertension
    • Uresin Y, Taylor A, Kilo C, et al.: Aliskiren, a novel renin inhibitor, has greater BP lowering than ramipril and additional BP lowering when combined with ramipril in patients with diabetes and hypertension. J Hypertens 2006, 24:S82.
    • (2006) J Hypertens , vol.24
    • Uresin, Y.1    Taylor, A.2    Kilo, C.3
  • 45
    • 33749866573 scopus 로고    scopus 로고
    • The novel oral renin inhibitor aliskiren provides effective blood pressure control in patients with hypertension when used alone or in combination with hydrochlorothiazide
    • Villamil A, Chrysant S, Calhoun D, et al.: The novel oral renin inhibitor aliskiren provides effective blood pressure control in patients with hypertension when used alone or in combination with hydrochlorothiazide. J Clin Hypertens 2006, 8:A100.
    • (2006) J Clin Hypertens , vol.8
    • Villamil, A.1    Chrysant, S.2    Calhoun, D.3
  • 46
    • 33846323219 scopus 로고    scopus 로고
    • Aliskiren as add-on to amlodipine provides significant additional blood pressure lowering without increased oedema associated with doubling the amlodipine dose
    • Munger MA, Drummond W, Essop MR, et al.: Aliskiren as add-on to amlodipine provides significant additional blood pressure lowering without increased oedema associated with doubling the amlodipine dose. Eur Heart J 2006, 27:117.
    • (2006) Eur Heart J , vol.27 , pp. 117
    • Munger, M.A.1    Drummond, W.2    Essop, M.R.3
  • 47
    • 33846449197 scopus 로고    scopus 로고
    • Once-daily aliskiren provides effective, smooth 24-hour blood pressure control in patients with hypertension
    • Mitchell J, Oh B, Herron J, et al.: Once-daily aliskiren provides effective, smooth 24-hour blood pressure control in patients with hypertension. J Clin Hypertens 2006, 8:A93.
    • (2006) J Clin Hypertens , vol.8
    • Mitchell, J.1    Oh, B.2    Herron, J.3
  • 48
    • 33747332458 scopus 로고    scopus 로고
    • The novel renin inhibitor aliskiren is not associated with rebound effects on blood pressure or plasma renin activity following treatment withdrawal
    • Herron J, Mitchell J, Oh B, et al.: The novel renin inhibitor aliskiren is not associated with rebound effects on blood pressure or plasma renin activity following treatment withdrawal. J Clin Hypertens 2006, 8:A86-87.
    • (2006) J Clin Hypertens , vol.8
    • Herron, J.1    Mitchell, J.2    Oh, B.3
  • 49
    • 33947223136 scopus 로고    scopus 로고
    • Aliskiren, a novel renin inhibitor, is well tolerated and has sustained BP-lowering effects alone or in combination with HCTZ during long-term (52 weeks) treatment of hypertension
    • Sica D, Gradman A, Lederballe O, et al.: Aliskiren, a novel renin inhibitor, is well tolerated and has sustained BP-lowering effects alone or in combination with HCTZ during long-term (52 weeks) treatment of hypertension. Eur Heart J 2006, 27:121.
    • (2006) Eur Heart J , vol.27 , pp. 121
    • Sica, D.1    Gradman, A.2    Lederballe, O.3
  • 50
    • 0028969452 scopus 로고
    • Renal vascular responses to renin inhibition with zankiren in men
    • Fisher ND, Hollenberg N: Renal vascular responses to renin inhibition with zankiren in men. Clin Pharmacol Ther 1995, 57:342-348.
    • (1995) Clin Pharmacol Ther , vol.57 , pp. 342-348
    • Fisher, N.D.1    Hollenberg, N.2
  • 51
    • 0034050578 scopus 로고    scopus 로고
    • Renal and systemic effects of continued treatment with renin inhibitor remikiren in hypertensive patients with normal and impaired renal function
    • van Paassen P, de Zeeuw D, Navis G, de Jong PE: Renal and systemic effects of continued treatment with renin inhibitor remikiren in hypertensive patients with normal and impaired renal function. Nephrol Dial Transplant 2000, 15:637-643.
    • (2000) Nephrol Dial Transplant , vol.15 , pp. 637-643
    • van Paassen, P.1    de Zeeuw, D.2    Navis, G.3    de Jong, P.E.4
  • 52
    • 25444454353 scopus 로고    scopus 로고
    • Aliskiren, a human renin inhibitor, ameliorates cardiac and renal damage in double-transgenic rats
    • Pilz B, Shagdarsuren E, Wellner M, et al.: Aliskiren, a human renin inhibitor, ameliorates cardiac and renal damage in double-transgenic rats. Hypertension 2005, 46:569-576.
    • (2005) Hypertension , vol.46 , pp. 569-576
    • Pilz, B.1    Shagdarsuren, E.2    Wellner, M.3
  • 53
    • 36849075533 scopus 로고    scopus 로고
    • Low-dose renin inhibitor and AT1 receptor blocker ameliorate angiotensin II-induced end-organ damage despite persistence of hypertension
    • Philadelphia, PA; November 8-13
    • Fiebeler A, Shagdarsuren E, Pilz B, et al.: Low-dose renin inhibitor and AT1 receptor blocker ameliorate angiotensin II-induced end-organ damage despite persistence of hypertension. Results presented at Renal Week. Philadelphia, PA; November 8-13, 2005.
    • (2005) Results presented at Renal Week
    • Fiebeler, A.1    Shagdarsuren, E.2    Pilz, B.3
  • 54
    • 34547882245 scopus 로고    scopus 로고
    • Aliskiren, a human renin inhibitor induces persistent renoprotection comparable to ACE inhibition in double transgenic rats (dTGR)
    • Feldman DL, Jin L, Miserindino-Moltini R, et al.: Aliskiren, a human renin inhibitor induces persistent renoprotection comparable to ACE inhibition in double transgenic rats (dTGR). Am J Hypertens 2005, 8:230A.
    • (2005) Am J Hypertens , vol.8
    • Feldman, D.L.1    Jin, L.2    Miserindino-Moltini, R.3
  • 55
    • 36849026490 scopus 로고    scopus 로고
    • The renin inhibitor aliskiren ameliorates hypertensive diabetic nephropathy in transgenic (nRen-2)27 (Ren-2) rats
    • Philadelphia, PA; November 8-13
    • Feldman DL, Jin L, Miserindino-Moltini R, et al.: The renin inhibitor aliskiren ameliorates hypertensive diabetic nephropathy in transgenic (nRen-2)27 (Ren-2) rats. Results presented at Renal Week. Philadelphia, PA; November 8-13, 2005.
    • (2005) Results presented at Renal Week
    • Feldman, D.L.1    Jin, L.2    Miserindino-Moltini, R.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.