Absorption-excipient-pH classification gradient maps: Sparingly soluble drugs and the pH partition hypothesis

European Journal of Pharmaceutical Sciences

Volumn 33, Issue 1, 2008, Pages 29-41

  Avdeef, Alex ^a   Kansy, Manfred ^b   Bendels, Stefanie ^b   Tsinman, Konstantin ^a  

^a PION INC   (United States)

^b F HOFFMANN LA ROCHE LTD   (Switzerland)

Author keywords

Absorption; Absorption excipient pH; Double sink PAMPA; Excipients; HP CD; Low solubility; NMP; PEG400; Propylene glycol; Sodium taurocholate

Indexed keywords

2 HYDROXYPROPYL BETA CYCLODEXTRIN; 2 PYRROLIDONE DERIVATIVE; ALBENDAZOLE; AMIODARONE; ASTEMIZOLE; BUTACAINE; CLOTRIMAZOLE; DIPYRIDAMOLE; EXCIPIENT; GLIBENCLAMIDE; GRISEOFULVIN; MACROGOL 400; MEFENAMIC ACID; METHYL 2 PYRROLIDONE; NAPROXEN; POTASSIUM CHLORIDE; PROGESTERONE; PROPYLENE GLYCOL; TAUROCHOLIC ACID; UNCLASSIFIED DRUG;

ACCURACY; AQUEOUS SOLUTION; ARTICLE; ARTIFICIAL MEMBRANE; DRUG ADSORPTION; DRUG SOLUBILITY; HIGH THROUGHPUT SCREENING; IN VITRO STUDY; IN VIVO STUDY; MAXIMUM PLASMA CONCENTRATION; MEMBRANE PERMEABILITY; PH MEASUREMENT; PRIORITY JOURNAL;

ANIMALS; BENZOIC ACID; BETA-CYCLODEXTRINS; CELL MEMBRANE; CELL MEMBRANE PERMEABILITY; DIFFUSION; EXCIPIENTS; HUMANS; HYDROGEN-ION CONCENTRATION; INTESTINAL ABSORPTION; JEJUNUM; MEMBRANES, ARTIFICIAL; PHARMACEUTICAL PREPARATIONS; RATS; REGRESSION ANALYSIS; SOFTWARE; SOLUBILITY; TECHNOLOGY, PHARMACEUTICAL;

EID: 36849018496     PISSN: 09280987     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ejps.2007.09.009     Document Type: Article

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