Inhibition of HIV-1 replication in macrophages by red blood cell-mediated delivery of a heterodinucleotide of lamivudine and tenofovir

Nucleosides, Nucleotides and Nucleic Acids

Volumn 26, Issue 8-9, 2007, Pages 953-957

  Franchetti, P ^a   Cappellacci, L ^a   Petrelli, R ^a   Vita, P ^a   Grifantini, M ^a   Rossi, L ^b   Pierige F ^b   Serafini, S ^b   Magnani, M ^b   Balestra, E ^c   Perno, C F ^c  

^a UNIVERSITY OF CAMERINO   (Italy)

^b UNIVERSITY OF URBINO   (Italy)

^c UNIVERSITY OF ROME TOR VERGATA   (Italy)

Author keywords

Anti HIV 1 activity; Heterodinucleotides; Human macrophages

Indexed keywords

ANTIVIRUS AGENT; DINUCLEOTIDE; LAMIVUDINE; NUCLEOSIDE ANALOG; PRODRUG; RNA DIRECTED DNA POLYMERASE INHIBITOR; TENOFOVIR;

ANTIVIRAL ACTIVITY; ARTICLE; DRUG STRUCTURE; HIGHLY ACTIVE ANTIRETROVIRAL THERAPY; HUMAN IMMUNODEFICIENCY VIRUS 1; MACROPHAGE; VIROGENESIS; VIRUS REPLICATION;

ADENINE; ANTI-HIV AGENTS; DRUG DELIVERY SYSTEMS; DRUG DESIGN; ERYTHROCYTES; HIV-1; HUMANS; LAMIVUDINE; MACROPHAGES; PHOSPHONIC ACIDS; VIRUS REPLICATION;

HUMAN IMMUNODEFICIENCY VIRUS 1;

EID: 36849017392     PISSN: 15257770     EISSN: 15322335     Source Type: Journal    
DOI: 10.1080/15257770701508067     Document Type: Article

References (9)

1. Marcello, A. Latency: The hidden HIV-1 challenge. Retrovirology 2006, 3, 7.
2. a) Crowe, S.M.; Sonza, S. HIV-1 can be recovered from a variety of cells including peripheral blood monocytes of patients receiving highly active antiretroviral therapy: a further obstacle to eradication. J. Leukoc. Biol. 2000, 68, 345-350;
3. b) Zhu, T.; Muthui, D.; Holte, S.; NIckle, D.; Feng, F.; Brodie, S.; Hwangbo, Y.; Mullins, J.I.; Corey, L. Evidence for human immunodeficiency virus type 1 replication in vivo in CD14(+) monocytes and its potential role as a source of virus in patients on highly active antiretroviral therapy. J. Virol. 2002, 76, 707-716;
4. c) Sonza, S.; Mutimer, H.P.; Oelrichs, R.; Jardine D.; Harvey K.; Dunne, A.; Purcell, D.F.; Birch, C.; Crowe, S.M. Monocytes harbour replication- competent, non-latent HIV-1 in patients on highly active antiretroviral therapy. AIDS 2001, 15, 17-22.
5. Acquaro, S.; Svicher, V.; Schols, D.; Pollicita, M.; Antinori, A.; Balzarini, J.; Perno, C.-F. Mechanisms underlyng activity of antiretroviral drugs in HIV-1-infected macrophages: New therapeutic strategies. J. Leukoc. Biol. 2006, 80, 1103-1110.
6. Perno, C.-F.; Yarchoan, R.; Cooney, D.A.; Hartman, N.R.; Gartner, S.; Popovic, M.; Hao, Z.; Gerrard, T. L.; Wilson, Y.A.; Johns, D.G. Inhibition of human immunodeficiency virus (HIV-1/HTLV-IIIBa-L) replication in fresh and cultured human peripheral blood monocytes/macrophages by azidothymidine and related 2′,3′-dideoxynucleosides. J. Exp. Med. 1988, 168, 1111-1125.
7. Rossi, L.; Serafini, S.; Franchetti, P.; Cappellacci, L.; Fraternale, A.; Casabianca, A.; Brandi, G.; Pierigé, F.; Perno, C.-F.; Balestra, E.; Benatti, U.; Millo, E.; Grifantini, M.; Magnani, M. Targeting nucleotide dimers containing antiviral nucleosides. Curr. Med. Chem. Anti-Infective Agents 2005, 4, 37-54 and references cited therein.
8. AIDSinfo. Guidelines for the use of antiretroviral agents in HIV-1-infected adults and adolescents. Rockville: A Service of the U.S. Department of Health and Human Services; 6 October 2005. http://aidsinfo.nih. gov/ContentFiles/AdultandAdolescentGL.pdf. Accessed August 2, 2006.
9. Magnani, M.; Rossi, L.; Brandi, G.; Schiavano, G.F.;Montroni, M.; Piedimonte, G. Targeting antiretroviral nucleotide analogues in phosphorylated form to macrophages: in vitro and in vivo studies. Proc. Natl. Acad. Sci. USA 1992, 89, 6477-6481.