A pilot study of Banxia Houpu Tang, a traditional Chinese medicine, for reducing pneumonia risk in older adults with dementia

Journal of the American Geriatrics Society

Volumn 55, Issue 12, 2007, Pages 2035-2040

  Iwasaki, Koh ^a   Kato, Shiro ^c,d   Monma, Yasutake ^b   Niu, Kaijun ^b   Ohrui, Takashi ^b   Okitsu, Reina ^b   Higuchi, Satoshi ^b   Ozaki, Shiro ^d   Kaneko, Noboru ^c   Seki, Takashi ^b   Nakayama, Katsutoshi ^b   Furukawa, Katsutoshi ^b   Fujii, Masahiko ^e   Arai, Hiroyuki ^b  

^a TOHOKU UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

^b TOHOKU UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^c DOKKYO UNIVERSITY   (Japan)

^d Kawachi gun   (Japan)

^e National Hospital Organization   (Japan)

Author keywords

Aspiration pneumonia; Banxia Houpu Tang; Complementary medicine; Elderly; Traditional medicine

Indexed keywords

BANXIA HOUPU TANG; HERBACEOUS AGENT; OSELTAMIVIR; UNCLASSIFIED DRUG;

AGED; ALZHEIMER DISEASE; ARTICLE; ASPIRATION PNEUMONIA; CEREBROVASCULAR DISEASE; CHINESE MEDICINE; CLINICAL TRIAL; CONFIDENCE INTERVAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DEMENTIA; DRUG SYNTHESIS; ELDERLY CARE; FEEDING BEHAVIOR; FEMALE; HUMAN; INFLUENZA; LONG TERM CARE; MAJOR CLINICAL STUDY; MALE; MORTALITY; PARKINSON DISEASE; PILOT STUDY; PNEUMONIA; PROPORTIONAL HAZARDS MODEL; RANDOMIZED CONTROLLED TRIAL; SINGLE BLIND PROCEDURE;

AGED; AGED, 80 AND OVER; ANALYSIS OF VARIANCE; DEMENTIA; DRUGS, CHINESE HERBAL; FEMALE; HUMANS; JAPAN; MALE; PILOT PROJECTS; PNEUMONIA; PROPORTIONAL HAZARDS MODELS; PROSPECTIVE STUDIES; TREATMENT OUTCOME;

EID: 36849014434     PISSN: 00028614     EISSN: 15325415     Source Type: Journal    
DOI: 10.1111/j.1532-5415.2007.01448.x     Document Type: Article

References (24)

1. Centers for Disease Control and Prevention. National Center for Health Statistics. National nursing home survey [on-line]. Available at Accessed June 9, 2006.
2. Yamaya M, Yanai M, Ohrui T et al. Interventions to prevent pneumonia among older adults. J Am Geriatr Soc 2001 49 : 85 90.
3. Arai T, Sekizawa K, Ohrui T et al. ACE inhibitors and protection against pneumonia in elderly patients with stroke. Neurology 2005 64 : 573 574.
4. Nakayama K, Sekizawa K, Sasaki H. ACE inhibitors and swallowing reflex. Chest 1998 113 : 1425.
5. Israli Z, Hall W. Cough and angioneurotic edema associated with angiotensin-converting enzyme inhibitor therapy: A review of the literature and pathophysiology. Ann Intern Med 1992 117 : 234 242.
6. Iwasaki K, Wang Q, Nakagawa T et al. The Traditional Chinese Medicine Banxia Houpo Tang improves swallowing reflex. Phytomed 1999 6 : 103 106.
7. Iwasaki K, Wang Q, Seki H et al. The effects of the traditional Chinese medicine, "Banxia Houpo Tang (Hange-Koboku To)" on the swallowing reflex in Parkinson's disease. Phytomed 2000 7 : 259 263.
8. Iwasaki K, Cyong JC, Kitada S et al. A traditional Chinese herbal medicine, banxia houpo tang, improves cough reflex of patients with aspiration pneumonia. J Am Geriatr Soc 2002 50 : 1751 1752.
9. Nakagawa T, Sekizawa K, Arai H et al. High incidence of pneumonia in elderly patients with basal ganglia infarction. Arch Intern Med 1997 157 : 321 324.
10. Folstein MF, Folstein SE, McHugh PR. "Mini-mental state". A practical method for grading the cognitive state of patients for the clinician. J Psychiatr Res 1975 12 : 189 198.
11. Mahoney FI, Barthel DW. Functional evaluation: The Barthel index. Md State Med J 1965 14 : 61 65.
12. Kokusai-shippei-bunrui Dai 10 pan Available at [Japanese] Accessed August 12, 2007.
13. Marik PE. Aspiration pneumonitis and aspiration pneumonia. N Eng J Med 2001 344 : 665 671.
14. Ohkubo T, Chapman N, Neal B et al. Effects of an angiotensin-converting enzyme inhibitor-based regimen on pneumonia risk. Am J Respir Crit Care Med 2004 169 : 1041 1045.
15. Nakagawa T, Wada H, Sekizawa K et al. Amantadine and pneumonia. Lancet 1999 353 : 1157.
16. Yoneyama T, Yoshida M, Matsui T et al. Oral care and pneumonia. Lancet 1999 354 : 515.
17. Zhongjin Z, Fanglun JY. Published in 2 or 3 AD (Han Dynasty). English edition by Luo XM. Published by New World Press, Beijing, 1987.
18. Kusano E. How to diagnose and treat a licorice-induced syndrome with findings similar to that of primary hyperaldosteronism. Intern Med 2004 43 : 5 6.
19. Takeshita K, Saisho Y, Kitamura K et al. Pneumonitis induced by ou-gon (scullcap). Intern Med 2001 40 : 764 768.
20. Nakagawa T, Sekizawa K, Nakajoh K et al. Silent cerebral infarction: A potential risk for pneumonia in the elderly. J Intern Med 2000 247 : 255 259.
21. Arai T, Yoshimi N, Fujiwara H et al. Serum substance P concentrations and silent aspiration in elderly patients with stroke. Neurology 2003 61 : 1625 1626.
22. Kaneko A, Cho S, Hirai K et al. Hange-Koboku-To, a Kampo medicine, modulates cerebral levels of 5-HT (5-hydroxytryptamine), NA (noradrenaline) and DA (dopamine) in mice. Phytother Res 2005 19 : 491 495.
23. Guo Y, Kong L, Wang Y et al. Antidepressant evaluation of polysaccharides from a Chinese herbal medicine Banxia-Houpu decoction. Phytother Res 2004 18 : 204 207.
24. Mylotte JM, Goodnough S, Gould M. Pneumonia versus aspiration pneumonitis in nursing home residents: Prospective application of a clinical algorithm. J Am Geriatr Soc 2005 53 : 755 761.