Effect of monosodium glutamate on apoptosis and Bcl-2/Bax protein level in rat thymocyte culture

Physiological Research

Volumn 56, Issue 5, 2007, Pages 619-626

  Pavlović, Voja ^a   Cekic S ^a   Kocic G ^a   Sokolovic D ^a   Zivkovic V ^a  

^a UNIVERSITY OF NI   (Serbia)

Author keywords

Apoptosis; Bax; Bcl 2; Monosodium glutamate; Thymocytes

Indexed keywords

AMINO ACID RECEPTOR STIMULATING AGENT; BAX PROTEIN, RAT; FLAVORING AGENT; GLUTAMATE SODIUM; PROTEIN BAX; PROTEIN BCL 2; UNCLASSIFIED DRUG;

ANIMAL; APOPTOSIS; ARTICLE; CELL CULTURE; CELL SURVIVAL; DOSE RESPONSE; DOWN REGULATION; DRUG EFFECT; MALE; METABOLISM; PATHOLOGY; RAT; THYMUS; TIME; WISTAR RAT;

ANIMALS; APOPTOSIS; BCL-2-ASSOCIATED X PROTEIN; CELL SURVIVAL; CELLS, CULTURED; DOSE-RESPONSE RELATIONSHIP, DRUG; DOWN-REGULATION; EXCITATORY AMINO ACID AGONISTS; FLAVORING AGENTS; MALE; PROTO-ONCOGENE PROTEINS C-BCL-2; RATS; RATS, WISTAR; SODIUM GLUTAMATE; THYMUS GLAND; TIME FACTORS;

EID: 36849012157     PISSN: 08628408     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (43)

1. ADAMS JM, CORY S: The Bcl-2 protein family: arbiters of cell survival. Science 281: 1322-1326, 1998.
2. ALMAWI XY, MELEMEDJIAN OK, JAOUDE MM: On the link between Bcl-2 family proteins and glucocorticoid-induced apoptosis. J Leukoc Biol 76: 7-14, 2004.
3. ANKARCRONA M, DYPBUKT JM, BONFOCO E, ZHIVOTOVSKY B, ORRENIUS S, LIPTON SA, NICOTERA P: Glutamate-induced neuronal death: a succession of necrosis or apoptosis depending on mitochondrial function. Neuron 15: 961-973, 1998.
4. ANTONELLA A, DELIA D, BORRELLO MG, BIASSONI D, GIARDINI R, FONTANELLA E, PEZZELLA F, PULFORD K, PIEROTTI M, PORTA GD: Flow cytometric detection of the mitochondrial Bcl-2 protein in normal and neoplastic human lymphoid cells. Cytometry 13: 502-509, 1992.
5. ANTONSSON B, MARTINOU JC: The Bcl-2 protein family. Exp Cell Res 256: 50-57, 2000.
6. BAUMANN CA, BADAMCHIAN M, GOLDSTEIN AL: Thymosin alpha1 is a time- and dose-dependent antagonist of dexamethasone-induced apoptosis of murine thymocytes in vitro. Int J Immunopharmacol 22: 1057-1066, 2000.
7. BLADON J, TAYLOR PC: Lymphocytes treated by extracorporeal photopheresis demonstrate a drop in the Bcl-2/Bax ratio: a possible mechanism involved in extracorporeal photopheresis-induced apoptosis. Dermatology 204: 104-107, 2002.
8. BOLDYREV AA, KAZEY VI, LEINSOO TA, MASKINA A, TYULINA O, JOHNSON P, TUNEVA JO, CHITTUR S, CARPENTER DO: Rodent lymphocytes express functionally active glutamate receptors. Biochem Biophys Res Commun 324: 133-139, 2004.
9. BONFOCO E, KRAINC D, ANKARCRONA M, NICOTERIA P, LIPTON SA: Apoptosis and necrosis: two distinct events induced, respectively, by mild and intense insults with N-methyl-D-aspartate or nitric oxide/superoxide in cortical cell cultures. Proc Natl Acad Sci USA 92: 7162-7166, 1998.
10. 2+ signals. J Cell Sci 114: 2213-2222, 2001.
11. BURLACU A: Regulation of apoptosis by Bcl-2 family proteins. J Cell Mol Med 7: 249-257, 2003.
12. CHOUDHARY P, MALIK VB, PURI S, AHLUWALIA P: Studies on the effects of monosodium glutamate on hepatic microsomal lipid peroxidation, calcium, ascorbic acid and glutathione and its dependent enzymes in adult male mice. Toxicol Lett 89: 71-76, 1996.
13. DESAGHER S, MARTINOU JC: Mitochondria as central control point of apoptosis. Trends Cell Biol 10: 369-377, 2000.
14. ERAY M, MATTO M, KAARTINEN M, ANDERSON L, PELKONEN J: Flow cytometric analysis of apoptotic subpopulations with a combination of annexin V-FITC, propidium iodide, and SYTO 17. Cytometry 43: 134-142, 2001.
15. GANOR Y, BESSER M, BEN-ZAKAY N, UNGER T, LEVITE M: Human T-cells express a functional ionotropic glutamate receptor GluR3, and glutamate by itself triggers integrin-mediated adhesion to laminin and fibronectin and chemotactic migration. J Immunol 170: 4362-4372, 2003.
16. GILL SS, PULIDO OM: Glutamate receptors in peripheral tissues: current knowledge, future research, and implications for toxicology. Toxicol Pathol 29: 208-223, 2001.
17. GILL SS, PULIDO OM, MUELLER RW, MCGUIRE PF: Immunochemical localization of the metabotropic glutamate receptors in the rat heart. Brain Res Bull 48: 143-146, 1999.
18. GILL SS, MUELLER RW, MCGUIRE PF, REFINED OM: Potential target sites in peripheral tissues for excitatory neurotransmission and excitotoxicity. Toxicol Pathol 28: 277-285, 2000.
19. HINOI E, TAKARADA T, UESHIMA T, TSUCHIHASHI Y, YONEDA Y: Glutamate signaling in peripheral tissues. Eur J Biochem 271: 1-13, 2004.
20. KANKI R, NAKAMIZO T, YAMASHITA H, KIHARA T, SAWADA H, UEMURA K, KAWAMATA J, SHIBASAKI H, AKAIKE A, SHIMOHAMA S: Effects of mitochondrial dysfunction on glutamate receptor-mediated neurotoxicity in cultured rat spinal motor neurons. Brain Res 1015: 73-81, 2004.
21. 2+ homeostasis. Neurosci Behav Physiol 32: 541-547, 2002.
22. KNUDSON CM, KORSMETER SJ: Bcl-2 and Bax function independently to regulate cell death. Nat Genet 16: 358-363, 1997.
23. KOOPMAN G, REUTELINGSPERGER CP, KUIJTEN GA, KEEHNEN RM, PALS ST, VAN OERS MH: Annexin V for flow cytometric detection of phosphatidylserine expression on B cells undergoing apoptosis. Blood 84: 1415-1420, 1994.
24. LANGENAU DM, JETTE C, BERGHMANS S, POLOMERO T, KANKI JP, KUTOK JK, LOOK AT: Suppression of apoptosis by bcl-2 overexpression in lymphoid cells of transgenic zebrafish. Blood 105: 3278-3285, 2005.
25. LECOEUR H, PREVOST MC, GOUGEON ML: Oncosis is associated with exposure of phosphatidylserine residues on the outside layer of the plasma membrane: a reconsideration of the specificity of the annexin V/propidium iodide assay. Cytometry 44: 65-72, 2001.
26. LIU X, ZHU XZ: Roles of p53, c-Myc, Bcl-2, Bax and caspases in glutamate-induced neuronal apoptosis and the possible neuroprotective mechanism of basic fibroblast growth factor. Mol Brain Res 71: 210-216, 1999.
27. LOMBARDI G, DISANZANI C, MIGLIO G, CANONICO PL, FANTOZZI R: Characterization of ionotropic glutamate receptors in human lymphocytes. Br J Pharmacol 133: 936-944, 2001.
28. LOMBARDI G, MIGLIO G, DIANZANI C, MESTURINI R, VARSALDI F, CHIOCCHETI A, DIANZANI U, FANTOZI R: Glutamate modulation of human lymphocyte growth: in vitro studies. Biochem Biophys Res Commun 318: 496-502, 2004.
29. MARTIN LJ, SIEBER FE, TRAYSTMAN RJ: Apoptosis and necrosis occur in separate neuronal populations in hippocampus and cerebellum after ischemia and are associated with differential alterations in metabotropic glutamate receptor signaling pathways. J Cereb Blood Flow Metab 20: 153-167, 2000.
30. MIGLIO G, VARSALDI F, DIANZANI C, FANTOZZI R, LOMBARDI G: Stimulation of group I metabotropic glutamate receptors evokes calcium signals and c-jun and c-fos gene expression in human T cells. Biochem Pharmacol 70: 189-199, 2005.
31. MOLTO L, RAYMAN P, PASZKIEWICZ-KOZIK E, THORNTON M, REESE L, THOMAS JC, DAS T, KUDO D, BUKOWSKI R, DERWEESH I, TANNENBAUM CS, FINKE JH: The Bcl-2 transgene protects T cells from renal cell carcinoma-mediated apoptosis. Clin Cancer Res 9: 4060-4068, 2003.
32. OKASHA SA, RYU S, DO Y, MCKALLIP RJ, NAGARKATTI M, NAGARKATTI PS: Evidence for estradiol-induced apoptosis and dysregulated T cell maturation in the thymus. Toxicology 163: 49-62, 2001.
33. PACHECO R, CIRUELA F, CASADO V, MALLOL J, GALLART T, LUIS C, FRANCO R: Group I metabotropic glutamate receptors mediate a dual role of glutamate in T-cell activation. J Biol Chem 279: 33352-33358, 2004.
34. PETER ME, HEUFELDER AE, HENGARTNER MO: Advances in apoptosis research. Proc Natl Acad Sci USA 94: 12736-12737, 1997.
35. REZZANI R, CORSETTI G, RODELLA L, ANGOSCINI P, LONATI P, BIANCHI R: Cyclosporine-A treatment inhibits the expression of metabotropic glutamate receptors in rat thymus. Acta Histochem 105: 81-87, 2003.
36. RITTER AM, BOYD LR: Development in the thymus: it takes two to tango. Immunol Today 14: 462-470, 1993.
37. SAVINO W, DARDENNE M: Neuroendocrine control of thymus physiology. Endocr Rev 21: 412-443, 2000.
38. SCHELMAN WR, ANDRES RD, SIPE KJ, KANG E, WEYHENMEYER JA: Glutamate mediates cell death and increases the Bax to Bcl-2 ratio in a differentiated neuronal cell line. Brain Res Mol Brain Res 128: 160-169, 2004.
39. SEDLACK TW, OLTVAI ZN, YANG E, WANG K, BOISE LH, THOMPSON CB, KORSMEYER SJ: Multiple Bcl-2 family members demonstrate selective dimerisations with Bax. Proc Natl Acad Sci USA 92: 7834-7838, 1995.
40. SKERRY TM, GENEVER PG: Glutamate signalling in non-neuronal tissues. Trends Pharmacol Sci 22: 174-181, 2001.
41. STORTO M, GRAZIA U, BATTAGLIA G, FELLI M, MARODER M, GULINO A, RAGONA G, NICOLETTI F, SCREPANTI I, FRATI L, CALOGERO A: Expression of metabotropic glutamate receptors in murine thymocytes and thymic stromal cells. J Neuroimmunol 109: 112-120, 2000.
42. STORTO M, SALLESE M, SALVATORE L, POULET R, CONDORELI DF, DELL'ALBANI P, MARCELLO MF, ROMEO R, PIOMBONI P, BARONE N, NICOLETTI F, DE BLASI A: Expression of metabotropic glutamate receptors in the rat and human testis. J Endocrinol 170: 71-78, 2001.
43. VERMES I, HAANEN C, STEFFENS-NAKKEN H, REUTELINGSPERGER C: A novel assay for apoptosis. Flow cytometric detection of phosphatidylserine expression on early apoptotic cells using fluorescein labelled Annexin V. J Immunol Methods 184: 39-51, 1995.