MBL2 variants in relation to common childhood infections and atopy-related phenotypes in a large German birth cohort

Pediatric Allergy and Immunology

Volumn 18, Issue 8, 2007, Pages 665-670

  Müller, Sebastian ^a   Keil, Thomas ^a   Grüber, Christoph ^a   Zitnik, Simona Eva ^b   Lau, Susanne ^a   Wahn, Ulrich ^a   Witt, Heiko ^a   Nickel, Renate ^a,c  

^a CHARITÉ UNIVERSITÄTSMEDIZIN BERLIN   (Germany)

^b UNIVERSITY CHILDREN S HOSPITAL   (Slovenia)

^c Department of Pediatric Pneumology and Immunology ^*  (Germany)

Author keywords

Association; Asthma; Atopic dermatitis (AD); Atopy; Infection; MBL

Indexed keywords

MANNOSE BINDING LECTIN 2;

ARTICLE; ASTHMA; ATOPY; CHILD; CHILDHOOD DISEASE; FLUORESCENCE RESONANCE ENERGY TRANSFER; GENE MUTATION; GENETIC VARIABILITY; GERMANY; HUMAN; INFANT; INFECTION; INNATE IMMUNITY; MAJOR CLINICAL STUDY; NEWBORN; PHENOTYPE; PRIORITY JOURNAL; PROSPECTIVE STUDY; RESPIRATORY TRACT INFECTION;

ASTHMA; CHILD; CHILD, PRESCHOOL; COHORT STUDIES; FEMALE; GENE FREQUENCY; GENETIC MARKERS; GENETIC PREDISPOSITION TO DISEASE; GENOTYPE; GERMANY; HAPLOTYPES; HUMANS; HYPERSENSITIVITY; INFANT; MALE; MANNOSE-BINDING LECTIN; PHENOTYPE; POLYMORPHISM, GENETIC; PROMOTER REGIONS (GENETICS); QUESTIONNAIRES; RESPIRATORY TRACT INFECTIONS;

EID: 36849001343     PISSN: 09056157     EISSN: 13993038     Source Type: Journal    
DOI: 10.1111/j.1399-3038.2007.00573.x     Document Type: Article

References (24)

1. Ikeda K, Sannoh T, Kawasaki N, Kawasaki T, Yamashina I. Serum lectin with known structure activates complement through the classical pathway. J Biol Chem 1987 : 262 : 7451 4.
2. Kawasaki N, Kawasaki T, Yamashina I. A serum lectin (mannan-binding protein) has complement-dependent bactericidal activity. J Biochem (Tokyo) 1989 : 106 : 483 9.
3. Garred P, Pressler T, Madsen HO, et al. Association of mannose-binding lectin gene heterogeneity with severity of lung disease and survival in cystic fibrosis. J Clin Invest 1999 : 104 : 431 7.
4. Sastry K, Herman GA, Day L, et al. The human mannose-binding protein gene. Exon structure reveals its evolutionary relationship to a human pulmonary surfactant gene and localization to chromosome 10. J Exp Med 1989 : 170 : 1175 89.
5. Turner MW. Mannose-binding lectin (MBL) in health and disease. Immunobiology 1998 : 199 : 327 39.
6. Garred P, Thiel S, Madsen HO, Ryder LP, Jensenius JC, Svejgaard A. Gene frequency and partial protein characterization of an allelic variant of mannan binding protein associated with low serum concentrations. Clin Exp Immunol 1992 : 90 : 517 21.
7. Madsen HO, Garred P, Thiel S, et al. Interplay between promoter and structural gene variants control basal serum level of mannan-binding protein. J Immunol 1995 : 155 : 3013 20.
8. Kilpatrick DC. Mannan-binding lectin and its role in innate immunity. Transfus Med 2002 : 12 : 335 52.
9. Koch A, Melbye M, Sorensen P, et al. Acute respiratory tract infections and mannose-binding lectin insufficiency during early childhood. JAMA 2001 : 285 : 1316 21.
10. Roy S, Knox K, Segal S, et al. MBL genotype and risk of invasive pneumococcal disease: a case-control study. Lancet 2002 : 359 : 1569 73.
11. Neth O, Hann I, Turner MW, Klein NJ. Deficiency of mannose-binding lectin and burden of infection in children with malignancy: a prospective study. Lancet 2001 : 358 : 614 8.
12. Garred P, Madsen HO, Hofmann B, Svejgaard A. Increased frequency of homozygosity of abnormal mannan-binding-protein alleles in patients with suspected immunodeficiency. Lancet 1995 : 346 : 941 3.
13. Cedzynski M, Szemraj J, Swierzko AS, et al. Mannan-binding lectin insufficiency in children with recurrent infections of the respiratory system. Clin Exp Immunol 2004 : 136 : 304 11.
14. Summerfield JA, Sumiya M, Levin M, Turner MW. Association of mutations in mannose binding protein gene with childhood infection in consecutive hospital series. BMJ 1997 : 314 : 1229 32.
15. Richardson VF, Larcher VF, Price JF. A common congenital immunodeficiency predisposing to infection and atopy in infancy. Arch Dis Child 1983 : 58 : 799 802.
16. Aittoniemi J, Soranummi H, Rovio AT, et al. Mannose-binding lectin 2 (MBL2) gene polymorphism in asthma and atopy among adults. Clin Exp Immunol 2005 : 142 120 4.
17. Hogaboam CM, Takahashi K, Ezekowitz RA, Kunkel SL, Schuh JM. Mannose-binding lectin deficiency alters the development of fungal asthma: effects on airway response, inflammation, and cytokine profile. J Leukoc Biol 2004 : 75 : 805 14.
18. Lau S, Nickel R, Niggemann B, et al. The development of childhood asthma: lessons from the German Multicentre Allergy Study (MAS). Paediatr Respir Rev 2002 : 3 : 265 72.
19. Illi S, von Mutius E, Lau S, et al. The natural course of atopic dermatitis from birth to age 7 years and the association with asthma. J Allergy Clin Immunol 2004 : 113 : 925 31.
20. Weidtman V. Diagnoseschlüssel für Pädiatrie. In : Hellbrügge T ed. Documenta pädiatrica, volume 11. Lübeck : Hansesches Verlagskontor, 1982.
21. Antonarakis SE. Recommendations for a nomenclature system for human gene mutations. Nomenclature Working Group. Hum Mutat 1998 : 11 : 1 3.
22. Uguz A, Berber Z, Coskun M, Halide Akbas S, Yegin O. Mannose-binding lectin levels in children with asthma. Pediatr Allergy Immunol 2005 : 16 : 231 5.
23. Thiel S, Holmskov U, Hviid L, Laursen SB, Jensenius JC. The concentration of the C-type lectin, mannan-binding protein, in human plasma increases during an acute phase response. Clin Exp Immunol 1992 : 90 : 31 5.
24. Aittoniemi J, Baer M, Soppi E, Vesikari T, Miettinen A. Mannan binding lectin deficiency and concomitant immunodefects. Arch Dis Child 1998 : 78 : 245 8.