Hemorrhagic, coagulant and fibrino(geno)lytic activities of crude venom and fractions from mapanare (Bothrops colombiensis) snakes

Comparative Biochemistry and Physiology - C Toxicology and Pharmacology

Volumn 147, Issue 1, 2008, Pages 113-121

  Girón, María E ^a   Salazar, Ana M ^b   Aguilar, Irma ^a   Pérez, John C ^c   Sánchez, Elda E ^c   Arocha Piñango, Carmen L ^b   Rodríguez Acosta, Alexis ^a   Guerrero, Belsy ^b  

^a UNIVERSIDAD CENTRAL DE VENEZUELA   (Venezuela)

^b INSTITUTO VENEZOLANO DE INVESTIGACIONES CIENTÍFICAS   (Venezuela)

^c TEXAS A AND M UNIVERSITY KINGSVILLE   (United States)

Author keywords

Bothrops colombiensis; Coagulation; Fibrinolysis; Intra population venom variability; Snake venom

Indexed keywords

BENZAMIDE; BLOOD CLOTTING FACTOR 10A; FIBRIN; FIBRINOGEN; KALLIKREIN; METALLOPROTEINASE INHIBITOR; PROCOAGULANT; PROTEINASE; SEPHAROSE; SNAKE VENOM; SNAKE VENOM ANTISERUM; THROMBIN; TISSUE PLASMINOGEN ACTIVATOR;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BLEEDING; BLOOD CLOTTING; BOTHROPS COLOMBIENSIS; CONTROLLED STUDY; FIBRINOGENOLYSIS; GEL FILTRATION CHROMATOGRAPHY; HEMOSTASIS; IMMUNIZATION; MALE; MOLECULAR WEIGHT; MOUSE; NONHUMAN; POLYACRYLAMIDE GEL ELECTROPHORESIS; PRIORITY JOURNAL; SNAKE; ZYMOGRAPHY;

BOTHROPS COLOMBIENSIS; LONCHOCARPUS GLAUCIFOLIUS; SERPENTES;

EID: 36749088930     PISSN: 15320456     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.cbpc.2007.09.001     Document Type: Article

References (41)

1. Aguilar I., Guerrero B., Salazar A.M., Girón M.E., Pérez J.C., Sánchez E.E., and Rodríguez-Acosta A. Individual venom variability in the South American rattlesnake Crotalus durissus cumanensis. Toxicon 50 (2007) 214-224
2. Anonymous. National Institute of Health, Principles of Laboratory Animal Care, USA (1985) 1-112 Pub. 85 No. 23
3. Austen D., and Rhymes I. A Laboratory Manual of Blood Coagulation (1975), Blackwell Scientific Publications, Oxford
4. Bello C.A., Hermogenes A.L., Magalhaes A., Veiga S.S., Gremski L.H., Richardson M., and Sanchez E.F. Isolation and biochemical characterization of a fibrinolytic proteinase from Bothrops leucurus (white-tailed jararaca) snake venom. Biochimie 88 (2006) 189-200
5. Bjarnason J.B., and Fox J.W. Hemorrhagic metalloproteinases from snake venoms. Pharmacol. Ther. 62 (1994) 325-372
6. Bogarin G., Morais J.F., Yamaguchi I.K., Stephano M.A., Marcelino J.R., Nishikawa A.K., Guidolin R., Rojas G., Higashi H.G., and Gutierrez J.M. Neutralization of crotaline snake venoms from Central and South America by antivenoms produced in Brazil and Costa Rica. Toxicon 38 (2000) 1429-1441
7. Carvajal Z., and Arocha-Piñango C.L. Estudio zimográfico de las fracciones purificadas del veneno de la Lonomia achelous. Rev. Iberoam. Tromb. Hemost. 4 (1991) 182-184
8. Chippaux J.P., Williams V., and White J. Snake venom variability: methods of study, results and interpretation. Toxicon 29 (1991) 1279-1303
9. Daltry J.C., Wuster W., and Thorpe R.S. Diet and snake venom evolution. Nature 379 (1996) 537-540
10. Gutierrez J.M., and Rucavado A. Snake venom metalloproteinases: their role in the pathogenesis of local tissue damage. Biochimie 82 (2000) 841-850
11. Gutierrez J.M., Gene J.A., Rojas G., and Cerdas L. Neutralization of proteolytic and hemorrhagic activities of Costa Rican snake venoms by a polyvalent antivenom. Toxicon 23 (1985) 887-893
12. Hofmann H., and Bon C. Blood coagulation induced by the venom of Bothrops atrox. 1. Identification, purification, and properties of a prothrombin activator. Biochemistry 26 (1987) 772-780
13. Jorge M.T., and Ribeiro L.A. The epidemiology and clinical picture of an accidental bite by the South American rattlesnake (Crotalus durissus). Rev. Inst. Med. Trop. Sao Paulo 34 (1992) 347-354
14. Jorge M.T., and Ribeiro L.A. Envenoming by the South American pit viper Bothrops neuwiedi Wagler. Ann. Trop. Med. Parasitol. 94 (2000) 731-734
15. Kamiguti A.S., and Cardoso J.L. Haemostatic changes caused by the venoms of South American snakes. Toxicon 27 (1989) 955-963
16. Kamiguti A.S., Matsunaga S., Spir M., Sano-Martins I.S., and Nahas L. Alterations of the blood coagulation system after accidental human inoculation by Bothrops jararaca venom. Braz. J. Med. Biol. Res. 19 (1986) 199-204
17. Kamiguti A.S., Cardoso J.L., Theakston R.D., Sano-Martins I.S., Hutton R.A., Rugman F.P., Warrell D.A., and Hay C.R. Coagulopathy and haemorrhage in human victims of Bothrops jararaca envenoming in Brazil. Toxicon 29 (1991) 961-972
18. Kamiguti A.S., Rugman F.P., Theakston R.D., Franca F.O., Ishii H., and Hay C.R. The role of venom haemorrhagin in spontaneous bleeding in Bothrops jararaca envenoming. Butantan Institute Antivenom Study Group. Thromb. Haemost. 67 (1992) 484-488
19. Kamiguti A.S., Hay C.R., Theakston R.D., and Zuzel M. Insights into the mechanism of haemorrhage caused by snake venom metalloproteinases. Toxicon 34 (1996) 627-642
20. Kini R.M. Anticoagulant proteins from snake venoms: structure, function and mechanism. Biochem. J. 397 (2006) 377-387
21. Laemmli U.K. Cleavage of structural proteins during the assembly of the head of bacteriophage T4. Nature 227 (1970) 680-685
22. Lande A. Takayasu's arteritis and congenital coarctation of the descending thoracic and abdominal aorta: a critical review. AJR. Am. J. Roentgenol. 127 (1976) 227-233
23. Loria G.D., Rucavado A., Kamiguti A.S., Theakston R.D., Fox J.W., Alape A., and Gutierrez J.M. Characterization of basparin A, a prothrombin-activating metalloproteinase, from the venom of the snake Bothrops asper that inhibits platelet aggregation and induces defibrination and thrombosis. Arch. Biochem. Biophys. 418 (2003) 13-24
24. Lowry O.H., Rosebrough N.J., Farr A.L., and Randall R.J. Protein measurement with the Folin phenol reagent. J. Biol. Chem. 193 (1951) 265-275
25. Markland Jr. F.S. Snake venom fibrinogenolytic and fibrinolytic enzymes: an updated inventory. Thromb. Haemost. 79 (1998) 668-674
26. Marsh N.A., and Arocha-Pinango C.L. Evaluation of the fibrin plate method for estimating plasminogen activators. Thromb. Diath. Haemorrh. 28 (1972) 75-88
27. Minton S.A., and Weinstein S.A. Geographic and ontogenic variation in venom of the western diamondback rattlesnake (Crotalus atrox). Toxicon 24 (1986) 71-80
28. Nishida S., Fujimura Y., Miura S., Ozaki Y., Usami Y., Suzuki M., Titani K., Yoshida I., Sugimoto M., and Yoshioka A. Purification and characterization of bothrombin, a fibrinogen-clotting serine protease from the venom of Bothrops jararaca. Biochemistry 33 (1994) 1843-1849
29. Rodríguez-Acosta A., Mondolfi A., Orihuela A., and Aguilar M. ¿Qué hacer frente a un accidente ofídico? Editorial Venediciones, Caracas, Venezuela (1995)
30. Salazar A.M., Rodríguez-Acosta A., Girón M.E., Aguilar I., and Guerrero B. A comparative analysis of the clotting and fibrinolytic activities of the mapanare (Bothrops atrox) snake venom from different geographical areas in Venezuela. Thromb. Res. 120 (2007) 95-104
31. Saldarriaga M.M., Otero R., Nuñez V., Toro M.F., Diaz A., and Gutierrez J.M. Ontogenetic variability of Bothrops atrox and Bothrops asper snake venoms from Colombia. Toxicon 42 (2003) 405-411
32. Sano-Martins I.S., Santoro M.L., Castro S.C., Fan H.W., Cardoso J.L., and Theakston R.D. Platelet aggregation in patients bitten by the Brazilian snake Bothrops jararaca. Thromb. Res. 87 (1997) 183-195
33. Sasa M. Diet and snake venom evolution: can local selection alone explain intraspecific venom variation. Toxicon 37 (1999) 249-252
34. Schägger H., and von Jagow G. Tricine-sodium dodecyl sulfate-polyacrylamide gel electrophoresis for the separation of proteins in the range from 1 to 100kDa. Anal. Biochem. 166 (1987) 368-379
35. Shashidharamurthy R., Jagadeesha D.K., Girish K.S., and Kemparaju K. Variations in biochemical and pharmacological properties of Indian cobra (Naja naja naja) venom due to geographical distribution. Mol. Cell. Biochem. 229 (2002) 93-101
36. Spearman-Karber R. Alternative methods of analysis for quantal responses. In: Finney D. (Ed). Statistical Method in Biological Assay (1978), Charles Griffin, London, U.K.
37. Stocker W., and Bode W. Structural features of a superfamily of zinc-endopeptidases: the metzincins. Curr. Opin. Struct. Biol. 5 (1995) 383-390
38. Swenson S., and Markland Jr. F.S. Snake venom fibrin(ogen)olytic enzymes. Toxicon 45 (2005) 1021-1039
39. Williams V., and White J. Variation in the composition of the venom from a single specimen of Pseudonaja textilis (common brown snake) over one year. Toxicon 30 (1992) 202-206
40. Williams V., White J., Schwaner T.D., and Sparrow A. Variation in venom proteins from isolated populations of tiger snakes (Notechis ater niger, N. scutatus) in South Australia. Toxicon 26 (1988) 1067-1075
41. Zingali R.B., Jandrot-Perrus M., Guillin M.C., and Bon C. Bothrojaracin, a new thrombin inhibitor isolated from Bothrops jararaca venom: characterization and mechanism of thrombin inhibition. Biochemistry 32 (1993) 10794-10802