Characterization of two distinct opsonic and protective epitopes within the alpha C protein of the group B Streptococcus

Infection and Immunity

Volumn 65, Issue 4, 1997, Pages 1462-1467

  Kling, David E ^a,b   Gravekamp, Claudia ^b   Madoff, Lawrence C ^b,c   Michel, James L ^b,d  

^a UNIVERSITY OF MASSACHUSETTS BOSTON   (United States)

^b BRIGHAM AND WOMEN S HOSPITAL   (United States)

^c HARVARD MEDICAL SCHOOL   (United States)

^d CHANNING LABORATORY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BACTERIAL ANTIGEN; BACTERIAL PROTEIN; EPITOPE; MONOCLONAL ANTIBODY; POLYCLONAL ANTIBODY; RECOMBINANT PROTEIN; STREPTOCOCCUS ANTIGEN;

ANIMAL MODEL; ANTIBODY SPECIFICITY; ARTICLE; BACTERIAL MENINGITIS; BACTERIAL VIRULENCE; ENZYME LINKED IMMUNOSORBENT ASSAY; ESCHERICHIA COLI; MOUSE; NEWBORN SEPSIS; NONHUMAN; OPSONIZATION; PHAGOCYTOSIS; PRIORITY JOURNAL; PROTEIN LOCALIZATION; PROTEIN PURIFICATION; STREPTOCOCCUS AGALACTIAE; STREPTOCOCCUS INFECTION;

EID: 0030909642     PISSN: 00199567     EISSN: None     Source Type: Journal    
DOI: 10.1128/iai.65.4.1462-1467.1997     Document Type: Article

References (35)

1. Baltimore, R. S., D. L. Kasper, C. J. Baker, and D. K. Goroff. 1977. Antigenic specificity of opsonophagocytic antibodies in rabbit anti-sera to group B streptococci. J. Immunol. 118:673-678.
2. 2-terminal sequences of types 5, 6, and 24 M proteins synthesized in tandem. J. Exp. Med. 166:647-656.
3. Beachey, E. H., G. H. Stollerman, R. H. Johnson, I. Ofek, and A. L. Bisno. 1979. Human immune response to immunization with a structurally defined polypeptide fragment of streptococcal M protein. J. Exp. Med. 150:862-877.
4. Beseth, B. D. 1992. A genetic analysis of phenotypic diversity of the C protein alpha antigen of group B Streptococcus. B.A. thesis. Harvard College, Cambridge, Mass.
5. DuBois, N. B. 1995. Genetic and phenotypic properties of the surface proteins of group B Streptococcus and the identification of a new protein. B.A. thesis. Harvard College, Cambridge, Mass.
6. Gallagher, S. A., and J. A. Smith. 1994. Electrophoretic separation of proteins, p. 10.2.1-10.2.21. In F. M. Ausubel, R. Brent, R. E. Kingston, D. D. Moore, J. G. Seidman, J. A. Smith, and K. Struhl (ed.). Current protocols in molecular biology, vol. 2. John Wiley & Sons, Inc., New York, N.Y.
7. Gravekamp, C., D. S. Horensky, J. L. Michel, and L. C. Madoff. 1996. Variation in repeat number within the alpha C protein of group B streptococci alters antigenicity and protective epitopes. Infect. Immun. 64:3576-3583.
8. Grodberg, J., and J. J. Dunn. 1988. ompT encodes the Escherichia coli outer membrane protease that cleaves T7 RNA polymerase during purification. J. Bacteriol. 170:1245-1253.
9. Heden, L. O., E. Frithz, and G. Lindahl. 1991. Molecular characterization of an IgA receptor from group B streptococci: sequence of the gene, identification of a proline-rich region with unique structure and isolation of N-terminal fragments with IgA-binding capacity. Eur. J. Immunol. 21:1481-1490.
10. Hervas, J. A., L. Gonzalez, J. Gil, L. C. Paoletti, L. C. Madoff, and V. J. Benedi. 1993. Neonatal group B streptococcal infection in Mallorca, Spain. Clin. Infect. Dis. 16:714-718.
11. Jerlstrom, P. G., G. S. Chhatwal, and K. N. Timmis. 1991. The IgA-binding beta antigen of the C protein complex of group B streptococci: sequence determination of its gene and detection of two binding regions. Mol. Microbiol. 5:843-849.
12. Kasper, D., L. Paoletti, L. Madoff, J. Michel, M. Wessels, and H. Jennings. 1994. Glycoconjugate vaccines for the prevention of group B streptococcal infections, p. 113-117. In E. Norrby (ed.), Vaccines 94, modern approaches to new vaccines including prevention of AIDS. Cold Spring Harbor Laboratory Press, Cold Spring Harbor, N.Y.
13. Kehoe, M. A. 1991. Group A streptococcal antigens and vaccine potential. Vaccine 9:797-806.
14. Lachenauer, C. S., and L. C. Madoff. 1996. A protective surface protein from type V group B streptococci shares N-terminal sequence homology with the alpha C protein. Infect. Immun. 64:4255-4260.
15. Lancefield, R. C., M. McCarty, and W. N. Everly. 1975. Multiple mouse-protective antibodies directed against group B streptococci. Special reference to antibodies effective against protein antigens. J. Exp. Med. 142:165-179.
16. Larsson, C., M. Stålhammar-Carlemalm, and G. Lindahl. 1996. Experimental vaccination against group B streptococcus, an encapsulated bacterium, with highly purified preparations of cell surface proteins Rib and a. Infect. Immun. 64:3518-3523.
17. Madoff, L. C., S. Hori, J. L. Michel, C. J. Baker, and D. L. Kasper. 1991. Phenotypic diversity in the alpha C protein of group B streptococci. Infect. Immun. 59:2638-2644.
18. Madoff, L. C., J. L. Michel, E. W. Gong, D. E. Kling, and D. L. Kasper. 1996. Group B streptococci escape host immunity by deletion of tandem repeat elements of the alpha C protein. Proc. Natl. Acad. Sci. USA 93:4131-4136.
19. Madoff, L. C., J. L. Michel, and D. L. Kasper. 1991. A monoclonal antibody identifies a protective C-protein alpha-antigen epitope in group B streptococci. Infect. Immun. 59:204-210.
20. Michel, J. L., L. C. Madoff, D. E. Kling, D. L. Kasper, and F. M. Ausubel. 1991. C proteins of group B streptococci, p. 214-218. In G. M. Dunny, P. P. Cleary, and L. L. McKay (ed.), Genetics and molecular biology of streptococci, lactococci, and enterococci. American Society for Microbiology, Washington, D.C.
21. Michel, J. L., L. C. Madoff, D. E. Kling, D. L. Kasper, and F. M. Ausubel. 1991. Cloned alpha and beta C-protein antigens of group B streptococci elicit protective immunity. Infect. Immun. 59:2023-2028.
22. Michel, J. L., L. C. Madoff, K. Olson, D. E. Kling, D. L. Kasper, and F. M. Ausubel. 1992. Large, identical, tandem repeating units in the C protein alpha antigen gene, bca, of group B streptococci. Proc. Natl. Acad. Sci. USA 89:10060-10064.
23. Navarre, W. W., and O. Schneewind. 1994. Proteolytic cleavage and cell wall anchoring at the LPXTG motif of surface proteins in Gram-positive bacteria. Mol. Microbiol. 14:115-121.
24. Paoletti, L. C., M. R. Wessels, F. Michon, J. DiFabio, H. J. Jennings, and D. L. Kasper. 1992. Group B Streptococcus type II polysaccharide-tetanus toxoid conjugate vaccine. Infect. Immun. 60:4009-4014.
25. Paoletti, L. C., M. R. Wessels, F. Michon, H. J. Jennings, and D. L. Kasper. 1992. Group B Streptococcus type III glycoconjugate vaccines. Trends Glycosci. Glycotechnol. 4:269-278.
26. Paoletti, L. C., M. R. Wessels, A. K. Rodewald, A. A. Shroff, H. J. Jennings, and D. L. Kasper. 1994. Neonatal mouse protection against infection with multiple group B streptococcal (GBS) serotypes by maternal immunization with a tetravalent GBS polysaccharide-tetanus toxoid conjugate vaccine. Infect. Immun. 62:3236-3243.
27. Rodewald, A. K., A. B. Onderdonk, H. B. Warren, and D. L. Kasper. 1992. Neonatal mouse model of group B streptococcal infection. J. Infect. Dis. 166:635-639.
28. Sasse, J. 1994. Detection of proteins, p. 10.6.1-10.6.8. In F. M. Ausubel, R. Brent, R. E. Kingston, D. D. Moore, J. G. Seidman, J. A. Smith, and K. Struhl (ed.), Current protocols in molecular biology, vol. 2. John Wiley & Sons, Inc., New York, N.Y.
29. Schneewind, O., D. Mihaylova-Petkov, and P. Model. 1993. Cell wall sorting signals in surface proteins of Gram-positive bacteria. EMBO J. 12:4803-4811.
30. Smith, J. A. 1994. Quantitation of proteins, p. 10.1.1-10.1.3. In F. M. Ausubel, R. Brent, R. E. Kingston, D. D. Moore, J. G. Seidman, J. A. Smith, and K. Struhl (ed.), Current protocols in molecular biology, vol. 2. John Wiley & Sons, Inc., New York, N.Y.
31. Stålhammar-Carlemalm, M., L. Stenberg, and G. Lindahl. 1993. Protein Rib: a novel group B streptococcal cell surface protein that confers protective immunity and is expressed by most strains causing invasive infections. J. Exp. Med. 177:1593-1603.
32. Tabor, S. 1994. DNA ligases, p. 3.14.3-3.14.4. In F. M. Ausubel, R. Brent, R. E. Kingston, D. D. Moore, J. G. Seidman, J. A. Smith, and K. Struhl (ed.), Current protocols in molecular biology, vol. 1. John Wiley & Sons, Inc., New York, N.Y.
33. Wästfelt, M., M. Stålhammar-Carlemalm, A. Delisse, T. Cabezon, and G. Lindahl. 1996. Identification of a family of streptococcal surface proteins with extremely repetitive structure. J. Biol. Chem. 271:18892-18897.
34. Weis, J. H. 1994. Plating and transferring cosmid and plasmid libraries, p. 6.2.1-6.2.3. In F. M. Ausubel, R. Brent, R. E. Kingston, D. D. Moore, J. G. Seidman, J. A. Smith, and K. Struhl (ed.), Current protocols in molecular biology, vol. 1. John Wiley & Sons, Inc., New York, N.Y.
35. Wessels, M. R., L. C. Paoletti, A. K. Rodewald, F. Michon, J. DiFabio, H. J. Jennings, and D. L. Kasper. 1993. Stimulation of protective antibodies against type Ia and Ib group B streptococci by a type la polysaccharidetetanus toxoid conjugate vaccine. Infect. Immun. 61:4760-4766.