Undifferentiated connective tissue diseases (UCTD): a new frontier for rheumatology

Best Practice and Research: Clinical Rheumatology

Volumn 21, Issue 6, 2007, Pages 1011-1023

  Mosca, Marta ^a   Tani, Chiara ^a   Bombardieri, Stefano ^a  

^a UNIVERSITY OF PISA   (Italy)

Author keywords

classification criteria; connective tissue diseases; systemic lupus erythematosus; undifferentiated connective tissue diseases

Indexed keywords

ANTINUCLEAR ANTIBODY;

ANEMIA; ARTHRALGIA; ARTHRITIS; AUTOIMMUNE DISEASE; CLINICAL FEATURE; CLINICAL PRACTICE; CONNECTIVE TISSUE DISEASE; DIAGNOSTIC APPROACH ROUTE; DISEASE CLASSIFICATION; DISEASE COURSE; HUMAN; INFLAMMATION; LEUKOPENIA; PATIENT IDENTIFICATION; PHOTOSENSITIVITY; PREGNANCY; PRIORITY JOURNAL; PROGNOSIS; RASH; RAYNAUD PHENOMENON; REVIEW; RHEUMATOLOGY; SENSITIVITY AND SPECIFICITY; SEROLOGY; SYMPTOM; THROMBOCYTOPENIA; UNDIFFERENTIATED CONNECTIVE TISSUE DISEASE; XEROPHTHALMIA; XEROSTOMIA;

AUTOIMMUNITY; CONNECTIVE TISSUE DISEASES; HUMANS; MORBIDITY; RHEUMATOLOGY; WORLD HEALTH;

EID: 36749050308     PISSN: 15216942     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.berh.2007.09.004     Document Type: Review

References (47)

1. Lockshin M.D. What is SLE? Editorial. The Journal of Rheumatology 16 (1989) 419-420
2. LeRoy E.C., Maricq H.R., and Kahaleh M.B. Undifferentiated connective tissue syndromes. Arthritis & Rheumatism 23 (1980) 341-343
3. Moutsopoulos H.M., and Talal N. Viewpoint. Connective tissue diseases: one disease or many?. Lupus 3 (1994) 5-10
4. Wigley F.M. When is scleroderma really scleroderma?. The Journal of Rheumatology 28 (2001) 1471-1473
5. Tan E.M., Cohen A.S., Fries J.F., et al. The 1982 revised criteria for the classification of systemic lupus erythematosus. Arthritis & Rheumatism 25 (1982) 1271-1277
6. Hochberg M.C. Updating the American College of Rheumatology revised criteria for the classification of systemic lupus erythematosus. Arthritis & Rheumatism 40 (1997) 1725
7. Sharp G.C. Diagnostic criteria for classification of MCTD. In: Kasukawa R., and Sharp G.C. (Eds). MCTD and Anti-Nuclear Antibodies (1987), Elsevier, Amsterdam 23-32
8. Bohan A., and Peter J.B. Polymyositis and dermatomyositis. Part I. The New England Journal of Medicine 292 (1975) 344-347
9. Bohan A., and Peter J.B. Polymyositis and dermatomyositis. Part II. The New England Journal of Medicine 292 (1975) 403-407
10. Arnett F.C., Edworthy S.M., Bloch D.A., et al. The American Rheumatism Association 1987 revised criteria for the classification of rheumatoid arthritis. Arthritis & Rheumatism 31 (1988) 315-324
11. Vitali C., Bombardieri S., Moutsopoulos H.M., et al. Preliminary criteria for the classification of Sjögren's syndrome. Results of a prospective concerted action supported by the European community. Arthritis & Rheumatism 36 (1993) 340-347
12. Miyakis S., Lockshin M.D., Atsumi T., et al. International consensus statement on an update of the classification criteria for definite antiphospholipid syndrome (APS). Journal of Thrombosis and Haemostasis 4 (2006) 295-306
13. Subcommitte for Scleroderma Criteria of the American Rheumatism Association Diagnostic and Therapeutic Criterion Committee: preliminary criteria for the classification of systemic sclerosis (scleroderma). Arthritis & Rheumatism 23 (1980) 581-590
14. Rand Mariq H., and Valter I. A working classification of scleroderma spectrum disordes: a proposal and the results of testing on a sample of patients. Clinical and Experimental Rheumatology 22 supplement 33 (2004) S5-S13
15. LeRoy E.C., and Medsger T.A. Criteria for the classification of early systemic sclerosis. The Journal of Rheumatology 28 (2001) 1573-1576
16. Belch J.J. Editorial. The clinical assessment of the scleroderma spectrum disorders. British Journal of Rheumatology 32 (1993) 353-356
17. Lazaro M.A., Maldonado Cocco J.A., Catoggio L.J., et al. Clinical and serologic characteristics of patients with overlap syndrome: is mixed connective tissue disease a distinct clinical entity?. Medicine (Baltimore) 68 (1989) 58-65
18. Lom-Orta H., Alarcon-Segovia D., and Diaz-Jouanen E. Systemic lupus erythematosus. Differences between patients who do, and who do not, fulfill classification criteria at the time of diagnosis. The Journal of Rheumatology 7 6 (1980 Nov-Dec) 831-837
19. Ganczarczyk L., Urowitz M.B., and Gladman D.D. Latent lupus. The Journal of Rheumatology 16 (1989) 475-478
20. Greer J.M., and Panush R.S. Incomplete lupus erythematosus. Archives of Internal Medicine 149 (1989) 2473-2476
21. Alarcón G.S., Williams G.V., Singer J.Z., et al. Early undifferentiated connective tissue disease. I. Early clinical manifestations in a large cohort of patients with undifferentiated connective tissue diseases compared with cohorts of well established connective tissue disease. The Journal of Rheumatology 18 (1991) 1332-1339
22. Calvo-Alén J., Alarcón G.S., Burgard S.L., et al. Systemic lupus erythematosus: predictors of its occurrence among a cohort of patients with early undifferentiated connective tissue disease: multivariate analyses and identification of risk factors. The Journal of Rheumatology 23 (1996) 469-475
23. Mosca M., Tavoni A., Neri R., et al. Undifferentiated connective tissue diseases: the clinical and serological profiles in 91 patients followed for at least 1 year. Lupus 7 (1998) 95-100
24. Danieli M.G., Fraticelli P., Salvi A., et al. Undifferentiated connective tissue disease: natural history and evolution into definite CTD assessed in 84 patients initially diagnosed as early UCTD. Clinical Rheumatology 17 (1998) 195-201
25. Danieli M.G., Fraticelli P., Franceschini F., et al. Five-year follow-up of 165 Italian patients with undifferentiated connective tissue diseases. Clinical and Experimental Rheumatology 17 (1999) 585-591
26. Dijkstra S., Nieuwenhuys E.J., and Swaak A.J. The prognosis and outcome of patients referred to an outpatient clinic for rheumatic diseases characterized by the presence of antinuclear antibodies (ANA). Scandinavian Journal of Rheumatology 28 (1999) 33-37
27. Williams H.J., Alarcón G.S., Joks R., et al. Early undifferentiated tissue disease. VI. An inception cohort after 10 years: disease remissions and changes in diagnoses in well established and undifferentiated CTD. The Journal of Rheumatology 26 (1999) 816-825
28. Vila L.M., Mayor A.M., Valentin A.H., et al. Clinical outcome and predictors of disease evolution in patients with incomplete lupus erythematosus. Lupus 9 (2000) 110-115
29. Mosca M., Neri R., and Bombardieri S. Undifferentiated connective tissue diseases (UCTD): a review of the literature and a proposal for preliminary classification criteria. Clinical and Experimental Rheumatology 17 (1999) 615-620
30. Swaak A.J., van de Brink H., Smeenk R.J., et al. Incomplete lupus erythematosus: results of a multicenter study under the supervision of the EULAR Standing Committee on International Clinical Studies Including Therapeutic Trials (ESCISIT). Rheumatology 40 (2001) 89-94
31. Cavazzana I., Franceschini F., Belfiore N., et al. Undifferentiated connective tissue disease with antibodies to Ro/SSA: clinical features and follow up of 148 patients. Clinical and Experimental Rheumatology 19 (2001) 403-409
32. Bodolay E., Csiki Z., Szekanecz Z., et al. Five-year follow-up of 665 Hungarian patients with undifferentiated connective tissue disease (UCTD). Clinical and Experimental Rheumatology 21 (2003) 313-320
33. Mosca M., Neri R., Bencivelli W., et al. Undifferentiated connective tissue disease: analysis of 83 patients with a minimum follow up of 5 years. The Journal of Rheumatology 29 (2002) 2345-2349
34. Alarcon G.S., Willkens R.F., Ward J.R., et al. Early undifferentiated connective tissue disease. IV. Musculoskeletal manifestations in a large cohort of patients with undifferentiated connective tissue diseases compared with cohorts of patients with well-established connective tissue diseases: follow-up analyses in patients with unexplained polyarthritis and patients with rheumatoid arthritis at baseline. Arthritis & Rheumatism 39 (1996) 403-414
35. Williams H.J., Alarcón G.S., Neuner R., et al. Early undifferentiated connective tissue disease. V. An inception cohort 5 years later: disease remissions and changes in diagnoses in well established and undifferentiated connective tissue diseases. The Journal of Rheumatology 25 (1998) 261-268
36. Swaak T., and Smeenk R. Detection of anti-dsDNA as a diagnostic tool: a prospective study in 441 non-systemic lupus erythematosus patients with anti-dsDNA antibody. Annals of the Rheumatic Diseases 44 (1985) 245-251
37. Arbuckle M.R., McClain M.T., Rubertone M.V., et al. Development of autoantibodies before the clinical onset of systemic lupus erythematosus. The New England Journal of Medicine 349 (2003) 1526-1533
38. Danieli M.G., Rossetti L., Fraticelli P., et al. Autoimmune thyroid diseases in patients with undifferentiated connective tissue diseases. Clinical Rheumatology 19 (2000) 42-46
39. Mosca M., Baldini C., and Bombardieri S. Undifferentiated connective tissue diseases in the 2004. Clinical and Experimental Rheumatology 22 (2004) S14-S18
40. Clegg D.O., Williams J.H., Singer J.Z., et al. Early undifferentiated connective tissue disease. II. The frequency of circulating antinuclear antibodies in patients with early rheumatic diseases. The Journal of Rheumatology 18 (1991) 1340-1343
41. Belfiore N., Rossi S., Bobbio-Pallavicini F., et al. Anti-Ro(SSA) 52 kDa and 60 kDa specificities in undifferentiated connective tissue disease. Joint Bone Spine 67 (2000) 183-187
42. Mosca M., Neri R., Srigini F., et al. Pregnancy outcome in patients with undifferentiated connective tissue disease: a preliminary study on 25 pregnancies. Lupus 11 (2002) 304-307
43. Doria A., Iaccarino L., Ghirardello A., et al. Pregnancy in rare autoimmune rheumatic diseases: UCTD, MCTD, myositis, systemic vasculitis and Bechet disease. Lupus 13 9 (2004) 690-695
44. Vazquez-Del Mercado M., Martin-Marquez B.T., Petri M.H., et al. Molecular mechanisms in normal pregnancy and rheumatic diseases. Clinical and Experimental Rheumatology 24 6 (2006 Nov-Dec) 707-712
45. Asherson R.A. New subsets of the antiphospholipid syndrome in 2006: "PRE-APS" (probable APS) and microangiopathic antiphospholipid syndromes ("MAPS"). Autoimmunity Reviews 6 (2006) 76-80
46. Czirják L., Kiss C.G., Lövei C., et al. Survey of Raynaud's phenomenon and systemic sclerosis based on a representative study of 10,000 South-Transdanubian Hungarian inhabitants. Clinical and Experimental Rheumatology 23 (2005) 801-808
47. Doria A., Mosca M., Gambari P.F., and Bombardieri S. Defining unclassifiable connective tissue diseases: incomplete, undifferentiated or both?. The Journal of Rheumatology 32 (2005) 213-215