Induced hyperammonemia alters neuropsychology, brain MR spectroscopy and magnetization transfer in cirrhosis

Hepatology

Volumn 37, Issue 4, 2003, Pages 931-939

  Balata, Sherzad ^a   Olde Damink, Steven W M ^a,b   Ferguson, Karen ^c   Marshall, Ian ^c,d   Hayes, Peter C ^a   Deutz, Nicolaas E P ^b   Williams, Roger ^e   Wardlaw, Joanna ^c   Jalan, Rajiv ^a,e  

^a ROYAL INFIRMARY OF EDINBURGH   (United Kingdom)

^b MAASTRICHT UNIVERSITY MEDICAL CENTER   (Netherlands)

^c WESTERN GENERAL HOSPITAL   (United Kingdom)

^d UNIVERSITY OF EDINBURGH   (United Kingdom)

^e ROYAL FREE AND UNIVERSITY COLLEGE MEDICAL SCHOOL   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

AMINO ACID; AMMONIA; CREATINE; GLUTAMIC ACID; GLUTAMINE; PLACEBO;

ADULT; AMMONIA BLOOD LEVEL; ARTICLE; BRAIN FUNCTION; BRAIN LEVEL; BRAIN METABOLISM; BRAIN WATER; CLINICAL ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; CREATININE CLEARANCE; FEMALE; HUMAN; HYPERAMMONEMIA; LIVER CIRRHOSIS; MALE; NEUROPSYCHOLOGICAL TEST; NEUROPSYCHOLOGY; NUCLEAR MAGNETIC RESONANCE IMAGING; PRIORITY JOURNAL; PROTON NUCLEAR MAGNETIC RESONANCE; RANDOMIZED CONTROLLED TRIAL; SINGLE BLIND PROCEDURE;

EID: 0037386224     PISSN: 02709139     EISSN: None     Source Type: Journal    
DOI: 10.1053/jhep.2003.50156     Document Type: Article

References (49)

1. Hahn M, Massen O, Nencki M, Pawlow J. Die Eck'sche fistel zwischen der unteren hohlvene und der pfortader und ihre folgen für den organismus. Arch Exp Path Pharm 1893;32:161-210.
2. Jalan R, Hayes PC. Hepatic encephalopathy and ascites. Lancet 1997;350:1309-1315.
3. Clemmesen JO, Larsen FS, Kondrup J, Hansen BA, Ott P. Cerebral herniation in patients with acute liver failure is correlated with arterial ammonia concentration. HEPATOLOGY 1999;29:648-653.
4. Kramer L, Tribl B, Gendo A, Zauner C, Schneider B, Ferenci P, Madl C. Partial pressure of ammonia versus ammonia in hepatic encephalopathy. HEPATOLOGY 2000;31:30-34.
5. Bessman AN, Hawkins R. The relative effects of enterically administered plasma and packed cells on circulating blood ammonia. Gastroenterology 1963;45:368-373.
6. Riordan SM, Williams R. Treatment of hepatic encephalopathy. N Engl J Med 1997;337:473-479.
7. Olde Damink SWM, Dejong CHC, Deutz NEP, Soeters PB. Effects of simulated upper gastrointestinal hemorrhage on ammonia and related amino acids in blood and brain of chronic portacaval-shunted rats. Metab Brain Dis 1997;12:121-135.
8. Jalan R, Olde Damink SWM, Lui HF, Glabus M, Deutz NEP, Hayes PC, Ebmeier KP. Oral amino acid load mimicking haemoglobin results in reduced regional cerebral perfusion and deterioration in memory tests in patients with cirrhosis of the liver. Metab Brain Dis 2003;18:37-49.
9. Olde Damink SWM, Deutz NEP, Dejong CHC, Soeters PB, Jalan R. Interorgan ammonia metabolism in liver failure. Neurochem Int 2002;41:177-188.
10. Oppong KN, Al-Mardini H, Thick M, Record CO. Oral glutamine challenge in cirrhotics pre- and post-liver transplantation: a psychometric and analyzed EEG study. HEPATOLOGY 1997;26:870-876.
11. Butterworth RF. The neurobiology of hepatic encephalopathy. Semin Liver Dis 1996;16:235-244.
12. Norenberg MD. Astrocytic-ammonia interactions in hepatic encephalopathy. Semin Liver Dis 1996;16:245-253.
13. Cordoba J, Alonso J, Rovira A, Jacas C, Sanpedro F, Castells L, Vargas V, et al. The development of low-grade cerebral edema in cirrhosis is supported by the evolution of (1)H-magnetic resonance abnormalities after liver transplantation. J Hepatol 2001;35:598-604.
14. Martinez-Hernandez A, Bell KP, Norenberg MD. Glutamine synthetase: glial localization in brain. Science 1977;25;195:1356-1358.
15. Jalan R, Dabos K, Redhead DN, Lee A, Hayes PC. Elevation of intracranial pressure following transjugular intrahepatic portosystemic stent-shunt for variceal haemorrhage. J Hepatol 1997;27:928-933.
16. McGowean JC. The physical basis of magnetization transfer imaging. Neurology 1999;53(Suppl 1):S9-S18.
17. van Buchem MA. Magnetization transfer: applications in neuroradiology. J Comput Assist Tomogr 1999;23(Suppl 1):S9-S18.
18. Grossman RI. Magnetization transfer in multiple sclerosis. Ann Neurol 1994;36(Suppl):S97-S99.
19. Henkelman RM, Stanisz GJ, Graham SJ. Magnetization transfer in MRI: a review. NMR Biomed 2001;14:57-64.
20. Stanisz GJ, Yoon RS, Joy ML, Henkelman RM. Why does MTR change with neuronal depolarization? Magn Reson Med 2002;47:472-475.
21. Makela HI, Kettunen MI, Grohn OH, Kauppinen RA. Quantitative T(1rho) and magnetization transfer magnetic resonance imaging of acute cerebral ischemia in the rat. J Cereb Blood Flow Metab 2002;22:547-558.
22. Kettunen MI, Grohn OH, Silvennoinen MJ, Penttonen M, Kauppinen RA. Effects of intracellular pH, blood, and tissue oxygen tension on T1rho relaxation in rat brain. Magn Reson Med 2002;48:470-477.
23. Hill RJ, Koningsberg W. The structure of human hemoglobin. J Biol Chem 1962;237:3151-3156.
24. Davies AD. The influence of age on trail making test performance. J Clin Psychol 1968;24:96-98.
25. Hindmarch I. Psychomotor function and psychoactive drugs. Br J Clin Pharmacol 1980;10:189-209.
26. Randt CT, Brown ER, Osborne DPJ. A memory test for longitudinal measurement of mild to moderate defects. Clin Neuropsychol 1980;2:184-197.
27. Frith CD, Leary J, Cahill C, Johnstone EC. Performance on psychological tests. Demographic and clinical correlates of the results of these tests. Br J Psychiatry Suppl 1991:26-9, 44-46.
28. 0 field shifts following the application of pulsed gradients by phase correction in the time domain. J Magn Reson 1986;69:151-155.
29. 1H MR spectra of brain using AMARES. NMR Biomed 1998;11:32-39.
30. Rovira A, Alonso J, Cucurella G, Nos C, Tintore M, Pedraza S, Rio J, et al. Evolution of multiple sclerosis lesions on serial contrast-enhanced T1-weighted and magnetization-transfer MR images. Am J Neuroradiol 1999; 20:1939-1945.
31. Grossman PI, Gomori JM, Ramer KN, Lexa FJ, Schnall MD. Magnetization transfer: theory and clinical applications in neuroradiology. Radiographics 1994;14:279-290.
32. Deutz NEP, Reijven PL, Bost MC, van Berlo CL, Soeters PB. Modification of the effects of blood on amino acid metabolism by intravenous isoleucine. Gastroenterology 1991;101:1613-1620.
33. Dejong CHC, Kampman MT, Deutz NEP, Soeters PB. Altered glutamine metabolism in rat portal drained viscera and hindquarter during hyperammonemia. Gastroenterology 1992;102:936-948.
34. Olde Damink SWM, Dejong CHC, Deutz NEP, van Berlo CLH, Soeters PB. Upper gastrointestinal bleeding: an ammoniagenic and catabolic event due to the total absence of isoleucine in the hemoglobin molecule. Med Hypotheses 1999;52:515-519.
35. Jalan R, Gooday R, O'Carroll RE, Redhead DN, Elton RA, Hayes PC. A prospective evaluation of changes in neuropsychological and liver function tests following transjugular intrahepatic portosystemic stent-shunt. J Hepatol 1995;23:697-705.
36. Jalan R, Olde Damink SWM, Deutz NEP, Lee A, Hayes PC. Moderate hypothermia for uncontrolled intracranial hypertension in acute liver failure. Lancet 1999;354:1164-1168.
37. Amodio P, Marchetti P, Del Piccolo F, Campo G, Rizzo C, Iemmolo RM, Gerunda G, et al. Visual attention in cirrhotic patients: a study on covert visual attention orienting. HEPATOLOGY 1998;27:1517-1523.
38. Weissenborn K, Heidenreich S, Ennen J, Ruckert N, Hecker H. Attention deficits in minimal hepatic encephalopathy. Metab Brain Dis 2001;16:13-19.
39. Douglass A, Al Mardini H, Record C. Amino acid challenge in patients with cirrhosis: a model for the assessment of treatments for hepatic encephalopathy. J Hepatol 2001;34:658-664.
40. Cooper AJ, Plum F. Biochemistry and physiology of brain ammonia. Physiol Rev 1987;67:440-519.
41. Cooper AJ, Mora SN, Cruz NF, Gelbard AS. Cerebral ammonia metabolism in hyperammonemic rats. J Neurochem 1985;44:1716-1723.
42. Fazekas JF, Ticktin WR, Ehrmantraut WR, Alman RW. Cerebral metabolism in hepatic insufficiency. Am J Med 1956;21:843-849.
43. Bessman SP, Bradley JE. Uptake of ammonia by muscle. Its implications in ammoniagenic coma. N Engl J Med 1955;253:1143-1147.
44. Webster LT, Gabuzda GJ. Ammonium uptake by the extremities and brain in hepatic coma. J Clin Invest 1958;37:414-424.
45. Bessman SP, Bessman AN. The cerebral and peripheral uptake of ammonia in liver disease with an hypothesis for the mechanism of hepatic coma. J Clin Invest 1955;34:622-628.
46. Haussinger D, Laubenberger J, vom Dahl S, Ernst T, Bayer S, Langer M, Gerok W, et al. Proton magnetic resonance spectroscopy studies on human brain myo-inositol in hypo-osmolarity and hepatic encephalopathy. Gastroenterology 1994;107:1475-1480.
47. Ross BD, Jacobson S, Villamil F, Korula J, Kreis R, Ernst T, Shonk T, et al. Subclinical hepatic encephalopathy: proton MR spectroscopic abnormalities. Radiology 1994;193:457-463.
48. Seery JP, Taylor-Robinson SD. The application of magnetic resonance spectroscopy to the study of hepatic encephalopathy. J Hepatol 1996;25:988-998.
49. Iwasa M, Kinosada Y, Nakatsuka A, Watanabe S, Adachi Y. Magnetization transfer contrast of various regions of the brain in liver cirrhosis. AJNR Am J Neuroradiol 1999;20:652-654.