The proteasome is involved in determining differential utilization of double-strand break repair pathways

Oncogene

Volumn 26, Issue 54, 2007, Pages 7601-7606

  Gudmundsdottir, K ^a   Lord, C J ^a   Ashworth, A ^a  

^a INSTITUTE OF CANCER RESEARCH   (United Kingdom)

Author keywords

BRCA2; Double strand break; DSS1; Proteasome

Indexed keywords

BRCA2 PROTEIN; DOUBLE STRANDED DNA; PROTEASOME; PROTEIN; RPN3 PROTEIN; RPN7 PROTEIN; SINGLE STRANDED DNA; UNCLASSIFIED DRUG;

ANALYTIC METHOD; ARTICLE; CONTROLLED STUDY; DNA REPAIR; DNA STRAND BREAKAGE; GENE CONVERSION; HUMAN; HUMAN CELL; MUTAGENIC ACTIVITY; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN INTERACTION;

BRCA2 PROTEIN; BREAST NEOPLASMS; DNA DAMAGE; DNA REPAIR; FEMALE; GENETIC PREDISPOSITION TO DISEASE; HUMANS; KINETICS; PROTEASOME ENDOPEPTIDASE COMPLEX; SACCHAROMYCES CEREVISIAE; SACCHAROMYCES CEREVISIAE PROTEINS;

SACCHAROMYCES CEREVISIAE;

EID: 36749022182     PISSN: 09509232     EISSN: 14765594     Source Type: Journal    
DOI: 10.1038/sj.onc.1210579     Document Type: Article

References (16)

1. Brummelkamp TR, Bernards R, Agami R. (2002). A system for stable expression of short interfering RNAs in mammalian cells. Science 296: 550-553.
2. Crackower MA, Scherer SW, Rommens JM, Hui CC, Poorkaj P, Soder S et al. (1996). Characterization of the split hand/split foot malformation locus SHFM1 at 7q21.3-q22.1 and analysis of a candidate gene for its expression during limb development. Hum Mol Genet 5: 571-579.
3. Funakoshi M, Li X, Velichutina I, Hochstrasser M, Kobayashi H. (2004). Sem1, the yeast ortholog of a human BRCA2-binding protein, is a component of the proteasome regulatory particle that enhances proteasome stability. J Cell Sci 117: 6447-6454.
4. Gudmundsdottir K, Lord CJ, Witt E, Tutt AN, Ashworth A. (2004). DSS1 is required for RAD51 focus formation and genomic stability in mammalian cells. EMBO Rep 5: 989-993.
5. Isono E, Saito N, Kamata N, Saeki Y, Toh EA. (2005). Functional analysis of Rpn6p, a lid component of the 26 S proteasome, using temperature-sensitive rpn6 mutants of the yeast Saccharomyces cerevisiae. J Biol Chem 280: 6537-6547.
6. Josse L, Harley ME, Pires IM, Hughes DA. (2006). Fission yeast Dss1 associates with the proteasome and is required for efficient ubiquitin-dependent proteolysis. Biochem J 393: 303-309.
7. Kojic M, Yang H, Kostrub CF, Pavletich NP, Holloman WK. (2003). The BRCA2-interacting protein DSS1 is vital for DNA repair, recombination, and genome stability in Ustilago maydis. Mol Cell 12: 1043-1049.
8. Kojic M, Zhou Q, Lisby M, Holloman WK. (2005). Brh2-Dss1 interplay enables properly controlled recombination in Ustilago maydis. Mol Cell Biol 25: 2547-2557.
9. Krogan NJ, Lam MH, Fillingham J, Keogh MC, Gebbia M, Li J et al. (2004). Proteasome involvement in the repair of DNA double-strand breaks. Mol Cell 16: 1027-1034.
10. Li J, Zou C, Bai Y, Wazer DE, Band V, Gao Q. (2006). DSS1 is required for the stability of BRCA2. Oncogene 25: 1186-1194.
11. Marston NJ, Richards WJ, Hughes D, Bertwistle D, Marshall CJ, Ashworth A. (1999). Interaction between the product of the breast cancer susceptibility gene BRCA2 and DSS1, a protein functionally conserved from yeast to mammals. Mol Cell Biol 19: 4633-4642.
12. Schauber C, Chen L, Tongaonkar P, Vega I, Lambertson D, Potts W et al. (1998). Rad23 links DNA repair to the ubiquitin/proteasome pathway. Nature 391: 715-718.
13. Sin N, Kim KB, Elofsson M, Meng L, Auth H, Kwok BH et al. (1999). Total synthesis of the potent proteasome inhibitor epoxomicin: a useful tool for understanding proteasome biology. Bioorg Med Chem Lett 9: 2283-2288.
14. Sone T, Saeki Y, Toh-e A, Yokosawa H. (2004). Sem1p is a novel subunit of the 26S proteasome from Saccharomyces cerevisiae. J Biol Chem 279: 28807-28816.
15. Tutt A, Bertwistle D, Valentine J, Gabriel A, Swift S, Ross G et al. (2001). Mutation in Brca2 stimulates error-prone homology-directed repair of DNA double-strand breaks occurring between repeated sequences. EMBO J 20: 4704-4716.
16. Yang H, Jeffrey PD, Miller J, Kinnucan E, Sun Y, Thoma NH et al. (2002). BRCA2 function in DNA binding and recombination from a BRCA2-DSS1-ssDNA structure. Science 297: 1837-1848.