Discovery of 3-arylpyrimidin-2,4-diones as GABA-gated chloride channel insecticides: Translation from target site to field

ACS Symposium Series

Volumn 948, Issue , 2007, Pages 153-166

  Lyga, John W ^a   Ali, Syed F ^a   Kinne, Lyle P ^a   Marek, F Larry ^a   Wusaty, Mark A ^a   Staetz, Charles A ^a   Willut, James ^a  

^a FMC CORPORATION   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

EID: 36749009181     PISSN: 00976156     EISSN: None     Source Type: Book Series    
DOI: 10.1021/bk-2007-0948.ch012     Document Type: Conference Paper

References (19)

1. Bloomquist, J. R. Annu. Rev. Entomol, 1996, 42, 163.
2. Gant, D. B.; Chalmers, A. E.; Wolff, M. A.; Hoffman, H. B.; Bushey, D. F. Reviews in Toxicology, 1998, 2, 147;
3. for a new radioligand based on fipronil see, Meegalla, S. K.; Doller, D.; Silver, G. M.; Wisnewski, N.; Soll, R. M.; Dhanoa, D.; Biorg. Med. Chem. Lett. 2003, 13, 4035.
4. Sammelson, R. E.; Caboni, P.; Durkin, K.; Casida, J. Bioorg. Med. Chem., 2004, 12, 3345.;
5. Ozoe, Y.; Akamatsu, M.; Pest. Manag. Sci. 2001, 57, 923;
6. Calder, J. A.; Wyatt, J. A.; Frenkel, D. A.; Casida, J. E. J. Comput. Aided Mol. Design. 1993, 7, 45.
7. Zhao, X.; Yeh, J. Z.; Salgado, V. L.; Narahashi, T. J. Pharmacol. Exp. Therapeutics, 2004, 310, 192
8. Deng, Y, Molecular Action of Insecticides on Ion Channels, ACS Symposium Series 591, Clark, J. M., ed., Washington, D.C., 1995; pp.230-250.
9. Cole, L. M.; Casida, J. E. Pestic. Biochem. Physiol. 1992, 44, 1.
10. Yagi, K; Akimoto, K.; Mimori, N.; Miyake, T.; Kudo,M.; Arai, K.; Ishi, S. Pest. Manag. Sci. 2000, 65.
11. Ozoe, Y.; Yagi, K.; Nakamura, M.; Akamatsu, M.; Miyake, T.; Matsumura, F. Pestic. Biochem. Phys., 2000, 66, 92-104.
12. Eldridge, R.; Lyga, J. W. AGRO-019, 225th ACS National Meeting, New Orleans, March 23-27, 2003
13. Free, S. M.; Wilson, J. W., J. Med. Chem., 1964, 7, 395.
14. Maravetz, L. L; Theodoridis, G., PCT Int. Appl. WO 9712884 (1997), CAN 126:330612
15. Hansch, C.; Leo, A. Exploring QSAR, American Chemical Society, Washington, D.C., 1995, Chapter 2.
16. "YFM Resistant to Dieldrin" was obtained from the University of Wisconsin
17. Alchemy 2000 (Tripos), MedChem Explore (MDL), and C2 (MSI
18. Schäfer, P.; Hamprecht, G.; Ouhl, M.; Westphalen, K-O.; Zagar, C. Chimia, 2003, 57, 715
19. McFarland, J. M.; Gans, D. J. J. Med. Chem, 1986, 29, 505.