5-Amino-1-(2,6-dichloro-4-trifluoromethyl-phenyl)-3-[3H 3]-methylsulfanyl-1H-pyrazole-4-carbonitrile (CTOM): Synthesis and characterization of a novel and selective insect GABA receptor radioligand

Bioorganic and Medicinal Chemistry Letters

Volumn 13, Issue 22, 2003, Pages 4035-4037

  Meegalla, Sanath K ^a   Doller, Dario ^a   Silver, Gary M ^b   Wisnewski, Nancy ^b   Soll, Richard M ^a   Dhanoa, Dale ^a  

^a JOHNSON AND JOHNSON   (United States)

^b HESKA CORPORATION   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

4 AMINOBUTYRIC ACID RECEPTOR; 4 AMINOBUTYRIC ACID RECEPTOR BLOCKING AGENT; 5 AMINO 1 (2,6 DICHLORO 4 TRIFLUOROPHENYL) 3 METHYLSULFANYL 1H PYRAZOLE 4 CARBONITRILE; BENZENE DERIVATIVE; DISULFIDE; INSECTICIDE; PYRAZOLE DERIVATIVE; RADIOLIGAND; SODIUM DERIVATIVE; TRITIUM; UNCLASSIFIED DRUG;

ALKYLATION; ANIMAL TISSUE; ARTICLE; BRAIN; HOUSE FLY; INSECT; INSECTICIDAL ACTIVITY; MAMMAL; MOUSE; NONHUMAN; STRUCTURE ACTIVITY RELATION;

INSECTA; MAMMALIA;

EID: 0242285596     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2003.08.042     Document Type: Article

References (5)

1. Hainzl D., Cole L.M., Casida J.E. Chem. Res. Toxicol. 11:1998;1529.
2. Bloomquist J.R. Annu. Rev. Entomol. 41:1996;163.
3. Villemin D., Ben Alloum A. Synthesis. 1991;301.
4. Dhanoa, D. S.; Meegalla, S.; Doller, D.; Soli, R. M. US Patent 6,409,988.
5. 3 as solvent. Chemical shifts are reported in ppm relative to tetramethylsilane as an internal standard. Mass spectra were recorded on a LCQ Finnigan mass spectrometer. Commercially available solvents and reagents were used as received. Flash chromatography was carried out using Merck Kieselgel 60 silica gel.