Myoblast and Fibroblast Therapy for Post-Prostatectomy Urinary Incontinence: 1-Year Followup of 63 Patients

Journal of Urology

Volumn 179, Issue 1, 2008, Pages 226-231

  Mitterberger, Michael ^a   Marksteiner, Rainer ^a   Margreiter, Eva ^a   Pinggera, Germar M ^a   Frauscher, Ferdinand ^a   Ulmer, Hanno ^a   Fussenegger, Martin ^b   Bartsch, Georg ^a   Strasser, Hannes ^a  

^a INNSBRUCK MEDICAL UNIVERSITY   (Austria)

^b Sisters of Charity Hospital   (Austria)

Author keywords

endoscopy; fibroblasts; myoblasts; stress; urinary incontinence

Indexed keywords

ADULT; AGED; ARTICLE; BLADDER SPHINCTER; CELL THERAPY; CONTROLLED STUDY; ECHOGRAPHY; FIBROBLAST; FOLLOW UP; HUMAN; HUMAN CELL; HUMAN TISSUE; MAJOR CLINICAL STUDY; MALE; MUSCLE BIOPSY; MYOBLAST; POSTOPERATIVE COMPLICATION; PREOPERATIVE EVALUATION; PRIORITY JOURNAL; PROSTATECTOMY; QUALITY OF LIFE; SCORING SYSTEM; SKELETAL MUSCLE; STRESS INCONTINENCE; THERAPY EFFECT; URETHRA FUNCTION; URODYNAMICS;

AGED; AGED, 80 AND OVER; FIBROBLASTS; FOLLOW-UP STUDIES; HUMANS; INJECTIONS; MALE; MIDDLE AGED; MYOBLASTS, SKELETAL; PROSTATECTOMY; TIME FACTORS; URINARY INCONTINENCE;

EID: 36749007321     PISSN: 00225347     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.juro.2007.08.154     Document Type: Article

References (20)

1. Aus G., Abbou C.C., Bolla M., Heidenreich A., Schmid H.P., van Poppel H., et al. EAU guidelines on prostate cancer. Eur Urol 48 (2005) 546
2. Bourcier A., Haab F., Koelbl H., Rao S., Resnick N., Salvatore S., et al. Pathophysiology of urinary incontinence, fecal incontinence and pelvic organ prolapse. In: Abrams P., Cardozo L., Khoury S., and Wein A. (Eds). Incontinence: 3rd International Consultation on Incontinence (2005), Health Publications Ltd, Plymouth, United Kingdom 423-484
3. Strasser H., Frauscher F., Helweg G., Colleselli K., Reissigl A., and Bartsch G. Transurethral ultrasound: evaluation of anatomy and function of the rhabdosphincter of the male urethra. J Urol 159 (1998) 100
4. Strasser H., Tiefenthaler M., Steinlechner M., Bartsch G., and Konwalinka G. Urinary incontinence in the elderly and age-dependent apoptosis of rhabdosphincter cells. Lancet 354 (1999) 918
5. Klingler H.C., and Marberger M. Incontinence after radical prostatectomy: surgical treatment options. Curr Opin Urol 16 (2006) 60
6. Strasser H., Berjukow S., Marksteiner R., Margreiter E., Hering S., and Bartsch G. Stem cell therapy for urinary stress incontinence. Exp Gerontol 39 (2004) 1259
7. Yiou R., Yoo J.J., and Atala A. Restoration of functional motor units in a rat model of sphincter injury by muscle precursor cell autografts. Transplantation 76 (2003) 1053
8. Yokoyama T., Yoshimura N., Dhir R., Qu Z., Fraser M.O., Kumon H., et al. Persistence and survival of autologous muscle derived cells versus bovine collagen as potential treatment of stress urinary incontinence. J Urol 165 (2001) 271
9. Groutz A., Blaivas J.G., Kesler S.S., Weiss J.P., and Chaikin D.C. Outcome results of transurethral collagen injection for female stress incontinence: assessment by urinary incontinence score. J Urol 164 (2000) 2006
10. Patrick D.L., Martin M.L., Bushnell D.M., Yalcin I., Wagner T.H., and Buesching D.P. Quality of life of women with urinary incontinence: further development of the incontinence quality of life instrument (I-QOL). Urology 53 (1999) 71
11. Strasser H., Marksteiner R., Margreiter E., Pinggera G.M., Mitterberger M., Frauscher F., et al. Autologous myoblasts and fibroblasts versus collagen in treatment of stress urinary incontinence in women: a randomised controlled trial. Lancet 369 (2007) 2179
12. Herschorn S.T., and J. Bruschini H. Surgical treatment of urinary incontinence in men. In: Abrams P., Cardozo L., Khoury S., and Wein A. (Eds). Incontinence: 3rd International Consultation on Incontinence (2005), Health Publications Ltd, Plymouth, United Kingdom 1250
13. Triaca V., Twiss C.O., and Raz S. Urethral compression for the treatment of postprostatectomy urinary incontinence: is history repeating itself?. Eur Urol 51 (2007) 304
14. Smith D.P., Beegle B.E., Noe H.N., and Wilson E.A. Does technique or material used affect bladder tissue reactions when injecting teflon or silicone paste?. Urology 48 (1996) 119
15. McKinney C.D., Gaffey M.J., and Gillenwater J.Y. Bladder outlet obstruction after multiple periurethral polytetrafluoroethylene injections. J Urol 153 (1995) 149
16. Sweat S.D., and Lightner D.J. Complications of sterile abscess formation and pulmonary embolism following periurethral bulking agents. J Urol 161 (1999) 93
17. Trigo-Rocha F., Gomes C.M., Pompeo A.C., Lucon A.M., and Arap S. Prospective study evaluating efficacy and safety of Adjustable Continence Therapy (ProACT) for post radical prostatectomy urinary incontinence. Urology 67 (2006) 965
18. Berjukow S., Margreiter E., Marksteiner R., Strasser H., Bartsch G., and Hering S. Membrane properties of single muscle cells of the rhabdosphincter of the male urethra. Prostate 58 (2004) 238
19. Law P.K., Goodwin T.G., Fang Q., Hall T.L., Quinley T., Vastagh G., et al. First human myoblast transfer therapy continues to show dystrophin after 6 years. Cell Transplant 6 (1997) 95
20. Watson D., Keller G.S., Lacombe V., Fodor P.B., Rawnsley J., and Lask G.P. Autologous fibroblasts for treatment of facial rhytids and dermal depressions. A pilot study. Arch Facial Plast Surg 1 (1999) 165