메뉴 건너뛰기




Volumn 22, Issue 12, 2007, Pages 3408-3410

The nephrin-based slit diaphragm: New insight into the signalling platform identifies targets for therapy

Author keywords

Filtration barrier; Glomerulus; Molecular biology; Nephrin; Protein complexes; Proteinuria; Signal transduction; Slit diaphragm

Indexed keywords

NEPHRIN;

EID: 36748999500     PISSN: 09310509     EISSN: 14602385     Source Type: Journal    
DOI: 10.1093/ndt/gfm403     Document Type: Review
Times cited : (19)

References (29)
  • 1
    • 12344250764 scopus 로고    scopus 로고
    • Chronic kidney disease: The global challenge
    • Meguid El Nahas A, Bello AK. Chronic kidney disease: the global challenge. Lancet 2005; 365: 331-340
    • (2005) Lancet , vol.365 , pp. 331-340
    • Meguid El Nahas, A.1    Bello, A.K.2
  • 2
    • 32444451549 scopus 로고    scopus 로고
    • Mechanisms of progression and regression of renal lesions of chronic nephropathies and diabetes
    • Remuzzi G, Benigni A, Remuzzi A. Mechanisms of progression and regression of renal lesions of chronic nephropathies and diabetes. J Clin Invest 2006; 116: 288-296
    • (2006) J Clin Invest , vol.116 , pp. 288-296
    • Remuzzi, G.1    Benigni, A.2    Remuzzi, A.3
  • 3
    • 33751084075 scopus 로고    scopus 로고
    • Molecular basis of the glomerular filtration: Nephrin and the emerging protein complex at the podocyte slit diaphragm
    • Patari-Sampo A, Ihalmo P, Holthofer H. Molecular basis of the glomerular filtration: nephrin and the emerging protein complex at the podocyte slit diaphragm. Ann Med 2006; 38: 483-492
    • (2006) Ann Med , vol.38 , pp. 483-492
    • Patari-Sampo, A.1    Ihalmo, P.2    Holthofer, H.3
  • 5
    • 33646400903 scopus 로고    scopus 로고
    • Clinical impact of research on the podocyte slit diaphragm
    • Johnstone DB, Holzman LB. Clinical impact of research on the podocyte slit diaphragm. Nat Clin Pract Nephrol 2006; 2: 271-282
    • (2006) Nat Clin Pract Nephrol , vol.2 , pp. 271-282
    • Johnstone, D.B.1    Holzman, L.B.2
  • 6
    • 0032015551 scopus 로고    scopus 로고
    • Positionally cloned gene for a novel glomerular protein-nephrin-is mutated in congenital nephrotic syndrome
    • Kestila M, Lenkkeri U, Mannikko M et al. Positionally cloned gene for a novel glomerular protein-nephrin-is mutated in congenital nephrotic syndrome. Mol Cell 1998; 1: 575-582
    • (1998) Mol Cell , vol.1 , pp. 575-582
    • Kestila, M.1    Lenkkeri, U.2    Mannikko, M.3
  • 7
    • 0034809972 scopus 로고    scopus 로고
    • Changes in the expression of nephrin gene and protein in experimental diabetic nephropathy
    • Aaltonen P, Luimula P, Astrom E et al. Changes in the expression of nephrin gene and protein in experimental diabetic nephropathy. Lab Invest 2001; 81: 1185-1190
    • (2001) Lab Invest , vol.81 , pp. 1185-1190
    • Aaltonen, P.1    Luimula, P.2    Astrom, E.3
  • 8
    • 1042303655 scopus 로고    scopus 로고
    • Expression of human nephrin mRNA in diabetic nephropathy
    • Toyoda M, Suzuki D, Umezono T et al. Expression of human nephrin mRNA in diabetic nephropathy. Nephrol Dial Transplant 2004; 19: 380-385
    • (2004) Nephrol Dial Transplant , vol.19 , pp. 380-385
    • Toyoda, M.1    Suzuki, D.2    Umezono, T.3
  • 9
    • 0035991392 scopus 로고    scopus 로고
    • Nephrin expression in the post-natal developing kidney in normotensive and hypertensive rats
    • Bonnet F, Tikellis C, Kawachi H et al. Nephrin expression in the post-natal developing kidney in normotensive and hypertensive rats. Clin Exp Hypertens 2002; 24: 371-381
    • (2002) Clin Exp Hypertens , vol.24 , pp. 371-381
    • Bonnet, F.1    Tikellis, C.2    Kawachi, H.3
  • 10
    • 0035210324 scopus 로고    scopus 로고
    • Podocin, a raft-associated component of the glomerular slit diaphragm, interacts with CD2AP and nephrin
    • Schwarz K, Simons M, Reiser J et al. Podocin, a raft-associated component of the glomerular slit diaphragm, interacts with CD2AP and nephrin. J Clin Invest 2001; 108: 1621-1629
    • (2001) J Clin Invest , vol.108 , pp. 1621-1629
    • Schwarz, K.1    Simons, M.2    Reiser, J.3
  • 11
    • 2542494061 scopus 로고    scopus 로고
    • Signaling at the slit diaphragm
    • Benzing T. Signaling at the slit diaphragm. J Am Soc Nephrol 2004; 15: 1382-1391
    • (2004) J Am Soc Nephrol , vol.15 , pp. 1382-1391
    • Benzing, T.1
  • 12
    • 0035161741 scopus 로고    scopus 로고
    • Characterization of Drosophila hibris, a gene related to human nephrin
    • Dworak HA, Charles MA, Pellerano LB, Sink H. Characterization of Drosophila hibris, a gene related to human nephrin. Development 2001; 128: 4265-4276
    • (2001) Development , vol.128 , pp. 4265-4276
    • Dworak, H.A.1    Charles, M.A.2    Pellerano, L.B.3    Sink, H.4
  • 14
    • 0035173597 scopus 로고    scopus 로고
    • The immunoglobulin-like protein Hibris functions as a dose-dependent regulator of myoblast fusion and is differentially controlled by Ras and Notch signaling
    • Artero RD, Castanon I, Baylies MK. The immunoglobulin-like protein Hibris functions as a dose-dependent regulator of myoblast fusion and is differentially controlled by Ras and Notch signaling. Development 2001; 128: 4251-4264
    • (2001) Development , vol.128 , pp. 4251-4264
    • Artero, R.D.1    Castanon, I.2    Baylies, M.K.3
  • 15
    • 0034858027 scopus 로고    scopus 로고
    • Involvement of lipid rafts in nephrin phosphorylation and organization of the glomerular slit diaphragm
    • Simons M, Schwarz K, Kriz W et al. Involvement of lipid rafts in nephrin phosphorylation and organization of the glomerular slit diaphragm. Am J Pathol 2001; 159: 1069-1077
    • (2001) Am J Pathol , vol.159 , pp. 1069-1077
    • Simons, M.1    Schwarz, K.2    Kriz, W.3
  • 16
    • 0344541695 scopus 로고    scopus 로고
    • Nephrin localizes at the podocyte filtration slit area and is characteristically spliced in the human kidney
    • Holthofer H, Ahola H, Solin ML et al. Nephrin localizes at the podocyte filtration slit area and is characteristically spliced in the human kidney. Am J Pathol 1999; 155: 1681-1687
    • (1999) Am J Pathol , vol.155 , pp. 1681-1687
    • Holthofer, H.1    Ahola, H.2    Solin, M.L.3
  • 17
    • 0033667643 scopus 로고    scopus 로고
    • Alternatively spliced nephrin in experimental glomerular disease of the rat
    • Luimula P, Aaltonen P, Ahola H, Palmen T, Holthofer H. Alternatively spliced nephrin in experimental glomerular disease of the rat. Pediatr Res 2000; 48: 759-762
    • (2000) Pediatr Res , vol.48 , pp. 759-762
    • Luimula, P.1    Aaltonen, P.2    Ahola, H.3    Palmen, T.4    Holthofer, H.5
  • 18
    • 2642524346 scopus 로고    scopus 로고
    • Molecular cloning and characterization of an endogenous antisense transcript of Nphs1
    • Ihalmo P, Rinta-Valkama J, Mai P et al. Molecular cloning and characterization of an endogenous antisense transcript of Nphs1. Genomics 2004; 83: 1134-1140
    • (2004) Genomics , vol.83 , pp. 1134-1140
    • Ihalmo, P.1    Rinta-Valkama, J.2    Mai, P.3
  • 20
    • 18344410673 scopus 로고    scopus 로고
    • Patari A, Forsblom C, Havana M, Taipale H, Groop PH, Holthofer H. Nephrinuria in Diabetic Nephropathy of Type 1 Diabetes. Diabetes 2003; 52: 2969-2974
    • Patari A, Forsblom C, Havana M, Taipale H, Groop PH, Holthofer H. Nephrinuria in Diabetic Nephropathy of Type 1 Diabetes. Diabetes 2003; 52: 2969-2974
  • 21
    • 0032838572 scopus 로고    scopus 로고
    • Directed membrane transport is involved in process formation in cultured podocytes
    • Simons M, Saffrich R, Reiser J, Mundel P. Directed membrane transport is involved in process formation in cultured podocytes. J Am Soc Nephrol 1999; 10: 1633-1639
    • (1999) J Am Soc Nephrol , vol.10 , pp. 1633-1639
    • Simons, M.1    Saffrich, R.2    Reiser, J.3    Mundel, P.4
  • 22
    • 11244258291 scopus 로고    scopus 로고
    • Viable podocytes detach in experimental diabetic nephropathy: Potential mechanism underlying glomerulosclerosis
    • Petermann AT, Pippin J, Krofft R et al. Viable podocytes detach in experimental diabetic nephropathy: potential mechanism underlying glomerulosclerosis. Nephron Exp Nephrol 2004; 98: e114-e123
    • (2004) Nephron Exp Nephrol , vol.98
    • Petermann, A.T.1    Pippin, J.2    Krofft, R.3
  • 24
    • 0034775038 scopus 로고    scopus 로고
    • Nephrin is expressed in the pancreatic beta cells
    • Palmen T, Ahola H, Palgi J et al. Nephrin is expressed in the pancreatic beta cells. Diabetologia 2001; 44: 1274-1280
    • (2001) Diabetologia , vol.44 , pp. 1274-1280
    • Palmen, T.1    Ahola, H.2    Palgi, J.3
  • 25
    • 0037707376 scopus 로고    scopus 로고
    • Clustering-induced tyrosine phosphorylation of nephrin by Src family kinases
    • Lahdenpera J, Kilpelainen P, Liu XL et al. Clustering-induced tyrosine phosphorylation of nephrin by Src family kinases. Kidney Int 2003; 64: 404-413
    • (2003) Kidney Int , vol.64 , pp. 404-413
    • Lahdenpera, J.1    Kilpelainen, P.2    Liu, X.L.3
  • 26
    • 9644273952 scopus 로고    scopus 로고
    • SRC-family kinase Fyn phosphorylates the cytoplasmic domain of nephrin and modulates its interaction with podocin
    • Li H, Lemay S, Aoudjit L, Kawachi H, Takano T. SRC-family kinase Fyn phosphorylates the cytoplasmic domain of nephrin and modulates its interaction with podocin. J Am Soc Nephrol 2004; 15: 3006-3015
    • (2004) J Am Soc Nephrol , vol.15 , pp. 3006-3015
    • Li, H.1    Lemay, S.2    Aoudjit, L.3    Kawachi, H.4    Takano, T.5
  • 27
    • 0038788840 scopus 로고    scopus 로고
    • Nephrin and CD2AP associate with phosphoinositide 3-OH kinase and stimulate AKT-dependent signalling
    • Huber TB, Hartleben B, Kim J et al. Nephrin and CD2AP associate with phosphoinositide 3-OH kinase and stimulate AKT-dependent signalling. Mol Cell Biol 2003; 23: 4917-4928
    • (2003) Mol Cell Biol , vol.23 , pp. 4917-4928
    • Huber, T.B.1    Hartleben, B.2    Kim, J.3
  • 28
    • 33646401549 scopus 로고    scopus 로고
    • Nephrin ectodomain engagement results in Src kinase activation, nephrin phosphorylation, Nck recruitment, and actin polymerization
    • Verma R, Kovari I, Soofi A, Nihalani D, Patrie K, Holzman LB. Nephrin ectodomain engagement results in Src kinase activation, nephrin phosphorylation, Nck recruitment, and actin polymerization. J Clin Invest 2006; 116: 1346-1359
    • (2006) J Clin Invest , vol.116 , pp. 1346-1359
    • Verma, R.1    Kovari, I.2    Soofi, A.3    Nihalani, D.4    Patrie, K.5    Holzman, L.B.6
  • 29
    • 33645746950 scopus 로고    scopus 로고
    • Nck adaptor proteins link nephrin to the actin cytoskeleton of kidney podocytes
    • Jones N, Blasutig IM, Eremina V et al. Nck adaptor proteins link nephrin to the actin cytoskeleton of kidney podocytes. Nature 2006; 440: 818-823
    • (2006) Nature , vol.440 , pp. 818-823
    • Jones, N.1    Blasutig, I.M.2    Eremina, V.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.