Thyroid function and volume in epileptic children using carbamazepine, oxcarbazepine and valproate

Pediatrics International

Volumn 49, Issue 6, 2007, Pages 822-826

  Hirfanoglu, Tugba ^a   Serdaroglu, Ayse ^a   Camurdan, Orhun ^a   Cansu, Ali ^a   Bideci, Aysun ^a   Cinaz, Peyami ^a   Gucuyener, Kivilcim ^a  

^a GAZI UNIVERSITY   (Turkey)

Author keywords

Anti epileptic drugs; Children; Epilepsy; Thyroid function; Thyroid volume

Indexed keywords

CARBAMAZEPINE; OXCARBAZEPINE; PROTIRELIN; THYROID HORMONE; THYROTROPIN; THYROXINE; VALPROIC ACID;

ADOLESCENT; ARTICLE; CHILD; CONTROLLED STUDY; EPILEPSY; FEMALE; FREE THYROXINE INDEX; HUMAN; HYPOTHYROIDISM; MAJOR CLINICAL STUDY; MALE; PRIORITY JOURNAL; PROVOCATION TEST; STATISTICAL SIGNIFICANCE; THYROID FUNCTION; THYROID HORMONE BLOOD LEVEL; THYROID WEIGHT; THYROTROPIN BLOOD LEVEL; THYROXINE BLOOD LEVEL; TREATMENT DURATION;

ADOLESCENT; ANTICONVULSANTS; CARBAMAZEPINE; CHILD; CHILD, PRESCHOOL; EPILEPSY; FEMALE; HUMANS; HYPOTHYROIDISM; MALE; ORGAN SIZE; THYROID FUNCTION TESTS; THYROID GLAND; THYROTROPIN; VALPROIC ACID;

EID: 36649009551     PISSN: 13288067     EISSN: 1442200X     Source Type: Journal    
DOI: 10.1111/j.1442-200X.2007.02456.x     Document Type: Article

References (21)

1. Harden CL. Therapeutic safety monitoring: What to look for and when to look for it. Epilepsia 2000 41 (Suppl. 8 S37 S44.
2. Isojarvi JI, Airaksinen KE, Repo M et al. Carbamazepine, serum thyroid hormones and myocardial function in epileptic patients. J. Neurol. Neurosurg. Psychiatry 1993 56 : 710 12.
3. Connacher AA, Borsey DQ, Browning MC et al. The effective evaluation of thyroid status in patients on phenytoin, carbamazepine or sodium valproate attending an epilepsy clinic. Postgrad. Med. J. 1987 63 : 841 5.
4. Eiris-Punal J, Del Rio-Garma M, Del Rio-Garma MC et al. Long-term treatment of children with epilepsy with valproate or carbamazepine may cause subclinical hypothyroidism. Epilepsia 1999 40 : 1761 6.
5. Larkin JG, Macphee GJ, Beastall GH, Brodie MJ. Thyroid hormone concentrations in epileptic patients. Eur. J. Clin. Pharmacol. 1989 36 : 213 16.
6. Hegedus L, Hansen JM, Luhdorf K et al. Increased frequency of goiter in epileptic patients on long-term phenytoin or carbamazepine treatment. Clin. Endocrinol. (Oxf). 1985 23 : 423 9.
7. Vainionpaa LK, Mikkonen K, Rattya J et al. Thyroid function in girls with epilepsy with carbamazepine, oxcarbazepine, or valproate monotherapy and after withdrawal of medication. Epilepsia 2004 45 : 197 203.
8. Surks IM, Sievert R. Drugs and thyroid function. N. Engl. J. Med. 1995 333 : 1688 93.
9. Rattya J, Turkka J, Pakarinen AJ et al. Reproductive effects of valproate, carbamazepine, and oxcarbazepine in men with epilepsy. Neurology 2001 56 : 31 6.
10. Isojarvi JIT, Turkka J, Pakarinen AJ et al. Thyroid function in men taking carbamazepine, oxcarbazepine, or valproate for epilepsy. Epilepsia 2001 42 : 930 34.
11. Rapaport R, Sills I, Patel U et al. Thyrotropin-releasing hormone stimulation tests in infants. J. Clin. Endocrinol. Metab. 1993 77 : 889 94.
12. Brunn J, Block U, Ruf G et al. [Volumetric analysis of thyroid lobes by real-time ultrasound.] Dtsch. Med. Wochenschr. 1981 106 : 1338 40 (in German).
13. Conran MJC, Kearney PJ, Callaghan MN et al. Hypothalamic pituitary function testing on children receiving carbamazepine or sodium valproate. Epilepsia 1985 26 : 585 8.
14. Verroti A, Basciani F, Morresi S et al. Thyroid hormones in epileptic children receiving carbamazepine and valproic acid. Pediatr. Neurol. 2001 25 : 43 6.
15. Tanaka K, Kodama S, Yokohama S et al. Thyroid function in children with long-term anticonvulsant treatment. Pediatr. Neurosci. 1987 13 : 90 94.
16. Joffe RT, Gold PW, Uhde TW, Post RM. The effects of carbamazepine on the thyrotropin response to thyrotropin-releasing hormone. Psychiatry Res. 1984 12 : 161 6.
17. Caksen H, Dulger H, Cesur Y et al. Evaluation of thyroid and parathyroid functions in children receiving long-term carbamazepine therapy. Int. J. Neurosci. 2003 113 : 1213 17.
18. Caksen H, Dulger H, Cesur Y et al. No effect of long-term valproate therapy on thyroid and parathyroid functions in children. Int. J. Neurosci. 2002 112 : 1371 4.
19. Tumbridge WMG, Evered DC, Hall R. Lipid profiles and cardiovascular disease in the Whickham area with particular reference to thyroid failure. Clin. Endocrinol. (Oxf.) 1977 7 : 495 508.
20. Cushing GW. Subclinical hypothyroidism. Understanding is the key to decision making. Postgrad. Med. 1993 94 : 95 107.
21. Oppenheimer JH, McPherson HT. The syndrome of iodide-induced goiter and myxedema. Am. J. Med. 1961 30 : 281 8.