A gene cluster that regulates both heterocyst differentiation and pattern formation in Anabaena sp. strain PCC 7120

Molecular Microbiology

Volumn 66, Issue 6, 2007, Pages 1429-1443

  Zhang, Wei ^a   Du, Ye ^a   Khudyakov, Ivan ^b   Fan, Qing ^c,d   Gao, Hong ^a   Ning, Degang ^a,e   Wolk, C Peter ^c   Xu, Xudong ^a  

^a INSTITUTE OF HYDROBIOLOGY   (China)

^b ST PETERSBURG STATE UNIVERSITY   (Russian Federation)

^c MICHIGAN STATE UNIVERSITY   (United States)

^d NORTHWESTERN UNIVERSITY   (United States)

^e JIANGSU UNIVERSITY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

NITROGEN;

ANABAENA; ARTICLE; BACTERIAL STRAIN; CELL DIFFERENTIATION; CONTROLLED STUDY; DOWN REGULATION; GENE CLUSTER; GENE EXPRESSION; GENE MUTATION; GENETIC TRANSCRIPTION; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; PROMOTER REGION;

ANABAENA; BACTERIAL PROTEINS; BLOTTING, NORTHERN; DNA, COMPLEMENTARY; GENE EXPRESSION REGULATION, BACTERIAL; GENES, BACTERIAL; MODELS, GENETIC; MULTIGENE FAMILY; MUTATION; NITROGEN FIXATION; POLYMERASE CHAIN REACTION; TRANSCRIPTION, GENETIC;

ANABAENA SP.; NOSTOC PUNCTIFORME;

EID: 36549083989     PISSN: 0950382X     EISSN: 13652958     Source Type: Journal    
DOI: 10.1111/j.1365-2958.2007.05997.x     Document Type: Article

References (52)

1. Black, T.A., Cai, Y. Wolk, C.P. (1993) Spatial expression and autoregulation of hetR, a gene involved in the control of heterocyst development in Anabaena. Mol Microbiol 9 : 77 84.
2. Borthakur, P.B., Orozco, C.C., Young-Robbins, S.S., Haselkorn, R. Callahan, S.M. (2005) Inactivation of patS and hetN causes lethal levels of heterocyst differentiation in the filamentous cyanobacterium Anabaena sp. PCC 7120. Mol Microbiol 57 : 111 123.
3. Buikema, W.J. Haselkorn, R. (1991) Characterization of a gene controlling heterocyst differentiation in the cyanobacterium Anabaena 7120. Genes Dev 5 : 321 330.
4. Buikema, W.J. Haselkorn, R. (2001) Expression of the Anabaena hetR gene from a copper-regulated promoter leads to heterocyst differentiation under repressing conditions. Proc Natl Acad Sci USA 98 : 2729 2734.
5. Cai, Y. Wolk, C.P. (1990) Use of a conditionally lethal gene in Anabaena sp. strain PCC 7120 to select for double recombinants and to entrap insertion sequences. J Bacteriol 172 : 3138 3145.
6. Cai, Y. Wolk, C.P. (1997) Nitrogen deprivation of Anabaena sp. strain PCC 7120 elicits rapid activation of a gene cluster that is essential for uptake and utilization of nitrate. J Bacteriol 179 : 258 266.
7. Callahan, S.M. Buikema, W.J. (2001) The role of HetN in maintenance of the heterocyst pattern in Anabaena sp. PCC 7120. Mol Microbiol 40 : 941 950.
8. Campbell, E.L., Summers, M.L., Christman, H., Martin, M.E. Meeks, J.C. (2007) Global gene expression patterns of Nostoc punctiforme in steady-state dinitrogen-grown heterocyst-containing cultures and at single time points during the differentiation of akinetes and hormogonia. J Bacteriol 189 : 5247 5256.
9. Castenholz, R.W. (1988) Culturing methods for cyanobacteria. Methods Enzymol 167 : 68 93.
10. Castenholz, R.W. (2001) Oxygenic photosynthetic bacteria. In Bergey's Manual of Systematic Bacteriology, 2nd edn, Vol. 1. Boone, D.R. Castenholz, R.W. (eds). New York : Springer-Verlag, pp. 474 599.
11. Curtis, S.E. Martin, J.A. (1994) The transcription apparatus and the regulation of transcription initiation. In The Molecular Biology of Cyanobacteria. Bryant, D.A. (ed.). Dordrecht, the Netherlands : Kluwer Academic Publishers, pp. 613 639.
12. Ehira, S. Ohmori, M. (2006a) NrrA, a novel nitrogen-responsive response regulator facilitates heterocyst development in the cyanobacterium Anabaena sp. strain PCC 7120. Mol Microbiol 59 : 1692 1703.
13. Ehira, S. Ohmori, M. (2006b) NrrA directly regulates the expression of hetR during heterocyst differentiation in the cyanobacterium Anabaena sp. strain PCC 7120. J Bacteriol 188 : 8520 8525.
14. Elhai, J. Wolk, C.P. (1988a) A versatile class of positive-selection vectors based on the nonviability of palindrome-containing plasmids that allows cloning into long polylinkers. Gene 68 : 119 138.
15. Elhai, J. Wolk, C.P. (1988b) Conjugal transfer of DNA to cyanobacteria. Methods Enzymol 167 : 747 754.
16. Elhai, J. Wolk, C.P. (1990) Developmental regulation and spatial pattern of expression of the structural genes for nitrogenase in the cyanobacterium Anabaena. EMBO J 9 : 3379 3388.
17. Ernst, A., Black, T., Cai, Y., Panoff, J.M., Tiwari, D.N. Wolk, C.P. (1992) Synthesis of nitrogenase in mutants of the cyanobacterium Anabaena sp. strain PCC 7120 affected in heterocyst development or metabolism. J Bacteriol 174 : 6025 6032.
18. Fan, Q., Huang, G., Lechno-Yossef, S., Wolk, C.P., Kaneko, T. Tabata, S. (2005) Clustered genes required for synthesis and deposition of envelope glycolipids in Anabaena sp. strain PCC 7120. Mol Microbiol 58 : 227 243.
19. Herrero, A., Muro-Pastor, A.M., Valladares, A. Flores, E. (2004) Cellular differentiation and the NtcA transcription factor in filamentous cyanobacteria. FEMS Microbiol Rev 28 : 469 487.
20. Hu, N.T., Thiel, T., Giddings, T.H. Wolk, C.P. (1981) New Anabaena and Nostoc cyanophages from sewage settling ponds. Virology 114 : 236 246.
21. Huang, X., Dong, Y. Zhao, J. (2004) HetR homodimer is a DNA-binding protein required for heterocyst differentiation, and the DNA-binding activity is inhibited by PatS. Proc Natl Acad Sci USA 101 : 4848 4853.
22. Huang, G., Fan, Q., Lechno-Yossef, S., Wojciuch, E., Wolk, C.P., Kaneko, T. Tabata, S. (2005) Clustered genes required for the synthesis of heterocyst envelope polysaccharide in Anabaena sp. strain PCC 7120. J Bacteriol 187 : 1114 1123.
23. Joung, J.K., Ramm, E.I. Pabo, C.O. (2000) A bacterial two-hybrid selection system for studying protein-DNA and protein-protein interactions. Proc Natl Acad Sci USA 97 : 7382 7387.
24. Khudyakov, I. Wolk, C.P. (1997) hetC, a gene coding for a protein similar to bacterial ABC protein exporters, is involved in early regulation of heterocyst differentiation in Anabaena sp. strain PCC 7120. J Bacteriol 179 : 6971 6978.
25. Khudyakov, I.Y. Golden, J.W. (2004) Different functions of HetR, a master regulator of heterocyst differentiation in Anabaena sp. PCC 7120, can be separated by mutation. Proc Natl Acad Sci USA 101 : 16041 16045.
26. Lang, J.D. Haselkorn, R. (1991) A vector for analysis of promoters in the cyanobacterium Anabaena sp. strain PCC 7120. J Bacteriol 173 : 2729 2731.
27. Laurent, S., Chen, H., Bédu, S., Ziarelli, F., Peng, L. Zhang, C.-C. (2005) Nonmetabolizable analogue of 2-oxoglutarate elicits heterocyst differentiation under repressive conditions in Anabaena sp. PCC 7120. Proc Natl Acad Sci USA 102 : 9907 9912.
28. Lee, M.H., Scherer, M., Rigali, S. Golden, J.W. (2003) PlmA, a new member of the GntR family, has plasmid maintenance functions in Anabaena sp. strain PCC 7120. J Bacteriol 185 : 4315 4325.
29. Li, B., Huang, X. Zhao, J. (2002) Expression of hetN during heterocyst differentiation and its inhibition of hetR up-regulation in the cyanobacterium Anabaena sp. PCC 7120. FEBS Lett 517 : 87 91.
30. Liang, J., Scappino, L. Haselkorn, R. (1992) The patA gene product, which contains a region similar to CheY of Escherichia coli, controls heterocyst pattern formation in the cyanobacterium Anabaena 7120. Proc Natl Acad Sci USA 89 : 5655 5659.
31. Meeks, J.C., Elhai, J., Thiel, T., Potts, M., Larimer, F., Lamerdin, J., et al. (2001) An overview of the genome of Nostoc punctiforme, a multicellular, symbiotic cyanobacterium. Photosynth Res 70 : 85 106.
32. Meeks, J.C., Cambell, E.L., Summers, M.L. Wong, F.C. (2002) Cellular differentiation in the cyanobacterium Nostoc punctiforme. Arch Microbiol 178 : 395 403.
33. Muro-Pastor, A.M., Olmedo-Verd, E. Flores, E. (2006) All4312, an NtcA-regulated two-component response regulator in Anabaena sp. strain PCC 7120. FEMS Microbiol Lett 256 : 171 177.
34. Ning, D. Xu, X. (2004a) A novel region involved in heterocyst development and pattern formation in the genome of Anabaena sp. PCC 7120. Shui Sheng Sheng Wu Xue Bao (Acta Hydrobiologica Sinica) 28 : 1 5 (in Chinese).
35. Ning, D. Xu, X. (2004b) alr0117, a two-component histidine kinase gene, is involved in heterocyst development in Anabaena sp. PCC 7120. Microbiology 150 : 447 453.
36. Orozco, C.C., Risser, D.D. Callahan, S.M. (2006) Epistasis analysis of four genes from Anabaena sp. strain PCC 7120 suggests a connection between PatA and PatS in heterocyst pattern formation. J Bacteriol 188 : 1808 1816.
37. Prentki, P., Binda, A. Epstein, A. (1991) Plasmid vectors for selecting IS1-promoted deletions in cloned DNA: sequence analysis of the omega interposon. Gene 103 : 17 23.
38. Risser, D.D. Callahan, S.M. (2007) Mutagenesis of hetR reveals amino acids necessary for HetR function in the heterocystous cyanobacterium Anabaena sp. strain PCC 7120. J Bacteriol 189 : 2460 2467.
39. Shi, Y., Zhao, W., Zhang, W., Ye, Z. Zhao, J. (2006) Regulation of intracellular free calcium concentration during heterocyst differentiation by HetR and NtcA in Anabaena sp. PCC 7120. Proc Natl Acad Sci USA 103 : 11334 11339.
40. Söding, J. (2005) Protein homology detection by HMM-HMM comparison. Bioinformatics 21 : 951 960.
41. Vieira, J. Messing, J. (1982) The pUC plasmids, an M13mp7-derived system for insertion mutagenesis and sequencing with synthetic universal primers. Gene 19 : 259 268.
42. Vioque, A. (1997) The RNase P RNA from cyanobacteria: short tandemly repeated repetitive (STRR) sequences are present within the RNase P RNA gene in heterocyst-forming cyanobacteria. Nucleic Acids Res 25 : 3471 3477.
43. Wang, Y. Xu, X. (2005) Regulation by hetC of genes required for heterocyst differentiation and cell division in Anabaena sp. strain PCC 7120. J Bacteriol 187 : 8489 8493.
44. Wolk, C.P., Ernst, A. Elhai, J. (1994) Heterocyst metabolism and development. In The Molecular Biology of Cyanobacteria. Bryant, D.A. (ed.). Dordrecht, the Netherlands : Kluwer Academic Publishers, pp. 769 823.
45. Wolk, C.P., Fan, Q., Zhou, R., Huang, G., Lechno-Yossef, S., Kuritz, T. Wojciuch, E. (2007) Paired cloning vectors for complementation of mutations in the cyanobacterium Anabaena sp. strain PCC 7120. Arch Microbiol (in press). doi: 10.1007/s00203-007-0276-z
46. Wong, F.C. Meeks, J.C. (2001) The hetF gene product is essential to heterocyst differentiation and affects HetR function in the cyanobacterium Nostoc punctiforme. J Bacteriol 183 : 2654 2661.
47. Wu, X., Liu, D., Lee, M.H. Golden, J.W. (2004) patS minigenes inhibit heterocyst development of Anabaena sp. strain PCC 7120. J Bacteriol 186 : 6422 6429.
48. Wu, X., Lee, D.W., Mella, R.A. Golden, J.W. (2007) The Anabaena sp. strain PCC 7120 asr1734 gene encodes a negative regulator of heterocyst development. Mol Microbiol 64 : 782 794.
49. Xu, X. Wolk, C.P. (2001) Role for hetC in the transition to a nondividing state during heterocyst differentiation in Anabaena sp. J Bacteriol 183 : 393 396.
50. Xu, X., Elhai, J. Wolk, C.P. (2008) Transcriptional and developmental responses by Anabaena to deprivation of fixed nitrogen. In Cyanobacteria: Molecular Biology, Genomics and Evolution. Herrero, T. Flores, E. (eds). Norwich : Horizon Scientific Press, pp. 383 422.
51. Yoon, H.-S. Golden, J.W. (1998) Heterocyst pattern formation controlled by a diffusible peptide. Science 282 : 935 938.
52. Zhang, C.-C., Laurent, S., Sakr, S., Peng, L. Bédu, S. (2006) Heterocyst differentiation and pattern formation in cyanobacteria: a chorus of signals. Mol Microbiol 59 : 367 375.