Tumor imaging using technetium-99m bound to pH-sensitive peptides

Nanomedicine: Nanotechnology, Biology, and Medicine

Volumn 3, Issue 4, 2007, Pages 297-305

  Mata, John E ^a   Dyal, Leslie A ^a   Slauson, Margorie E ^a   Summerton, James E ^b   Loehr, Christiane ^a   Tyson, Arhie Reid ^a   Rodriguez Proteau, Rosita ^a   Gustafson, Scott B ^a  

^a OREGON STATE UNIVERSITY   (United States)

^b Gene Tools LLC   (United States)

Author keywords

Cancer; Drug delivery; Nanotechnology; Peptide delivery; Tumor imaging

Indexed keywords

PEPTIDE DELIVERY; TUMOR IMAGING;

DRUG DELIVERY; NANOTECHNOLOGY; ONCOLOGY; PEPTIDES;

MEDICAL IMAGING;

AMINO ACID; FLUORESCEIN; PAP1 PEPTIDE TC 99M; PEPTIDE; RADIOPHARMACEUTICAL AGENT; TECHNETIUM 99M; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CANCER MODEL; CELL MEMBRANE; CONTROLLED STUDY; DIAGNOSTIC IMAGING; DRUG LABELING; DRUG PENETRATION; FLOW CYTOMETRY; FLUORESCENCE MICROSCOPY; GAMMA SCINTIGRAPHY; HYDROPHILICITY; IN VITRO STUDY; ISOTOPE LABELING; LIPOPHILICITY; MACROMOLECULE; MOUSE; NONHUMAN; PH; TUMOR DIAGNOSIS;

ANIMALS; CELL LINE, TUMOR; HYDROGEN-ION CONCENTRATION; IMAGE ENHANCEMENT; LUNG NEOPLASMS; MAMMARY NEOPLASMS, ANIMAL; METABOLIC CLEARANCE RATE; MICE; PEPTIDES; PROTEIN BINDING; RADIOPHARMACEUTICALS; TECHNETIUM; TISSUE DISTRIBUTION;

MURINAE;

EID: 36549081869     PISSN: 15499634     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.nano.2007.08.001     Document Type: Article

References (24)

1. Mordon S., Devoisselle J.M., and Maunoury V. In vivo pH measurement and imaging of tumor tissue using a pH-sensitive fluorescent probe (5,6-carboxyfluorescein): instrumental and experimental studies. Photochem Photobiol 60 (1994) 274-279
2. Tagashira Y., Takeda S., Kawano K., and Amano S. Continuous pH measuring by means of microglass electrode inserted in living normal and tumor tissues (2nd report), with an additional report on interaction of SH-group of animal protein with carcinogenic agent in the carcinogenetic mechanism. Gan 45 (1954) 99-101
3. Thistlethwaite A.J., Alexander G.A., Moylan D.J., and Leeper D.B. Modification of human tumor pH by elevation of blood glucose. Int J Radiat Oncol Biol Phys 13 (1987) 603-610
4. Drexler K.E. Molecular engineering: an approach to the development of general capabilities for molecular manipulation. Proc Natl Acad Sci U S A 78 (1981) 5275-5278
5. Mata J.E., Dyal L.A., Rossi V.M., and Gustafson S.B. Solid tumor physiology as a target for nanomedicines. In: Nalwa H.S., and Webster T. (Eds). Cancer Nanomedicine Cancer Nanotechnology-Nanomaterials for cancer diagnosis and therapy (2006), American Scientific Publishers, Valencia (Calif) 215-233
6. Reshetnyak Y.K., Andreev O.A., Lehnert U., and Engelman D.M. Translocation of molecules into cells by pH-dependent insertion of a transmembrane helix. Proc Natl Acad Sci U S A 103 (2006) 6460-6465
7. Summerton J.E. Transporter compositions and methods for detecting and killing cells in acidic areas of tumors. Published United States patent application 7,132,393.
8. Summerton J., and Weller D. Molecular engine for transporting drugs across cell membranes. Nucleosides Nucleotides 16 (1997) 1785-1788
9. Summerton J, Weller D. Polypeptide composition able to reversibly transmit between lipophilic and hydrophilic forms-useful for transporting compounds across lipid layers. Published international patent application 97-549493/50 (1997).
10. Rusckowski M., Qu T., Gupta S., Ley A., and Hnatowich D.J. A comparison in monkeys of (99m)Tc labeled to a peptide by 4 methods. J Nucl Med 42 (2001) 1870-1877
11. Gerweck L.E., Vijayappa S., and Kozin S. Tumor pH controls the in vivo efficacy of weak acid and base chemotherapeutics. Mol Cancer Ther 5 (2006) 1275-1279
12. McSheehy P.M., Stubbs M., and Griffiths J.R. Role of pH in tumor-trapping of the anticancer drug 5-fluorouracil. Adv Enzyme Regul 40 (2000) 63-80
13. Laurencot C.M., and Kennedy K.A. Influence of pH on the cytotoxicity of cisplatin in EMT6 mouse mammary tumor cells. Oncol Res 7 (1995) 371-379
14. Raghunand N., Mahoney B.P., and Gillies R.J. Tumor acidity, ion trapping and chemotherapeutics. II. pH-dependent partition coefficients predict importance of ion trapping on pharmacokinetics of weakly basic chemotherapeutic agents. Biochem Pharmacol 66 (2003) 1219-1229
15. Mahoney B.P., Raghunand N., Baggett B., and Gillies R.J. Tumor acidity, ion trapping and chemotherapeutics. I. Acid pH affects the distribution of chemotherapeutic agents in vitro. Biochem Pharmacol 66 (2003) 1207-1218
16. Junior A.D., Mota L.G., Nunan E.A., Wainstein A.J., Wainstein A.P., and Leal A.S. Tissue distribution evaluation of stealth pH-sensitive liposomal cisplatin versus free cisplatin in Ehrlich tumor-bearing mice. Life Sci 80 (2007) 659-664
17. Sethuraman V.A., Na K., and Bae Y.H. pH-responsive sulfonamide/PEI system for tumor specific gene delivery: an in vitro study. Biomacromolecules 7 (2006) 64-70
18. Shenoy D., Little S., Langer R., and Amiji M. Poly(ethylene oxide)-modified poly(beta-amino ester) nanoparticles as a pH-sensitive system for tumor-targeted delivery of hydrophobic drugs: part 2. In vivo distribution and tumor localization studies. Pharm Res 22 (2005) 2107-2114
19. Mrkvan T., Sirova M., Etrych T., Chytil P., Strohalm J., and Plocova D. Chemotherapy based on HPMA copolymer conjugates with pH-controlled release of doxorubicin triggers anti-tumor immunity. J Control Release 110 (2005) 119-129
20. Brannon-Peppas L., and Blanchette J.O. Nanoparticle and targeted systems for cancer therapy. Adv Drug Deliv Rev 56 (2004) 1649-1659
21. Steiniger S.C., Kreuter J., Khalansky A.S., Skidan I.N., Bobruskin A.I., and Smirnova Z.S. Chemotherapy of glioblastoma in rats using doxorubicin-loaded nanoparticles. Int J Cancer 109 (2004) 759-767
22. Oyewumi M.O., Yokel R.A., Jay M., Coakley T., and Mumper R.J. Comparison of cell uptake, biodistribution and tumor retention of folate-coated and PEG-coated gadolinium nanoparticles in tumor-bearing mice. J Control Release 95 (2004) 613-626
23. Lu Z., Yeh T.K., Tsai M., Au J.L., and Wientjes M.G. Paclitaxel-loaded gelatin nanoparticles for intravesical bladder cancer therapy. Clin Cancer Res 10 (2004) 7677-7684
24. Guccione S., Li K.C., and Bednarski M.D. Vascular-targeted nanoparticles for molecular imaging and therapy. Methods Enzymol 386 (2004) 219-236