Impact of hepatitis B virus (HBV) X gene integration in liver tissue on hepatocellular carcinoma development in serologically HBV-negative chronic hepatitis C patients

Journal of Hepatology

Volumn 48, Issue 1, 2008, Pages 43-50

  Toyoda, Hidenori ^a   Kumada, Takashi ^a   Kaneoka, Yuji ^a   Murakami, Yoshiki ^b  

^a OGAKI MUNICIPAL HOSPITAL   (Japan)

^b KYOTO UNIVERSITY   (Japan)

Author keywords

Chronic hepatitis C; HBV X integration; Hepatocellular carcinoma

Indexed keywords

HEPATITIS B ANTIGEN; HEPATITIS B VIRUS X PROTEIN;

ADULT; ALU SEQUENCE; ARTICLE; CONTROLLED STUDY; DISEASE ASSOCIATION; FEMALE; FIBROSIS; FOLLOW UP; GENE SEQUENCE; GENOME; HEPATITIS B; HEPATITIS B VIRUS; HUMAN; LIVER BIOPSY; LIVER CELL CARCINOMA; LIVER CIRRHOSIS; MAJOR CLINICAL STUDY; MALE; NEEDLE BIOPSY; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; SERODIAGNOSIS;

ADULT; CARCINOMA, HEPATOCELLULAR; DNA; FEMALE; GENOME, VIRAL; HEPATITIS B VIRUS; HEPATITIS C, CHRONIC; HUMANS; LIVER; LIVER CIRRHOSIS; LIVER NEOPLASMS; MALE; MIDDLE AGED; PROSPECTIVE STUDIES; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; VIRAL REGULATORY AND ACCESSORY PROTEINS; VIRUS INTEGRATION;

EID: 36549060123     PISSN: 01688278     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jhep.2007.08.016     Document Type: Article

References (32)

1. Beasley R.P. Hepatitis B virus. The major etiology of hepatocellular carcinoma. Cancer 61 (1988) 1942-1956
2. Kiyosawa K., Sodeyama T., Tanaka E., Gibo Y., Yoshizawa K., Nakano Y., et al. Interrelationship of blood transfusion, non-A, non-B hepatitis and hepatocellular carcinoma: analysis by detection of antibody to hepatitis C virus. Hepatology 12 (1990) 671-675
3. Di Bisceglie A.M., Goodman Z.D., Ishak K.G., Hoofnagle J.H., Melpolder J.J., and Alter H.J. Long-term clinical and histopathological follow-up of chronic posttransfusion hepatitis. Hepatology 14 (1991) 969-974
4. Brechot C., Jaffredo F., Lagorce D., Gerken G., Meyer zum Buschenfelde K., Papakonstontinou A., et al. Impact of HBV, HCV and GBV-C/HGV on hepatocellular carcinomas in Europe: results of a European concerted action. J Hepatol 29 (1998) 173-183
5. Cacciola I., Pollicino T., Squadrito G., Cerenzia G., Orlando M.E., and Raimondo G. Occult hepatitis B virus infection in patients with chronic hepatitis C liver disease. N Engl J Med 341 (1999) 22-26
6. Tamori A., Nishiguchi S., Kubo S., Koh N., Moriyama Y., Fujimoto S., et al. Possible contribution to hepatocarcinogenesis of X transcript of hepatitis B virus in Japanese patients with hepatitis C virus. Hepatology 29 (1999) 1429-1434
7. Pollicino T., Squadrito G., Cerenzia G., Cacciola I., Raffa G., Craxi A., et al. Hepatitis B virus maintains its pro-oncogenic properties in the case of occult HBV infection. Gastroenterology 126 (2004) 102-110
8. Urashima T., Saigo K., Kobayashi S., Imaseki H., Matsubara H., Koide Y., et al. Identification of hepatitis B virus integration in hepatitis C virus-infected hepatocellular carcinoma tissues. J Hepatol 26 (1997) 771-778
9. Kawai S., Yokosuka O., Imazeki F., Maru Y., and Saisho H. State of HBV DNA in HBsAg-negative, anti-HCV-positive hepatocellular carcinoma: existence of HBV DNA possibly as nonintegrated form with analysis by Alu-HBV DNA PCR and conventional HBV PCR. J Med Virol 64 (2001) 410-418
10. Tamori A., Nishiguchi S., Kubo S., Enomoto M., Koh N., Takeda T., et al. Sequencing of human-viral DNA junctions in hepatocellular carcinoma from patients with HCV and occult HBV infection. J Med Virol 69 (2003) 475-481
11. Intraobserver and interobserver variations in liver biopsy interpretation in patients with chronic hepatitis C. The French METAVIR Cooperative Study Group. Hepatology 1994;20:15-20.
12. Minami M., Poussin K., Brechot C., and Paterlini P. A novel PCR technique using Alu specific primers to identify unknown flanking sequences from the human genome. Genomics 29 (1995) 403-408
13. Murakami Y., Minami M., Daimon Y., and Okanoue T. Hepatitis B virus DNA in liver, serum, and peripheral blood mononuclear cells after the clearance of serum hepatitis B virus surface antigen. J Med Virol 72 (2004) 203-214
14. Murakami Y., Saigo K., Takashima H., Minami M., Okanoue T., Brechot C., et al. Large scaled analysis of hepatitis B virus (HBV) DNA integration in HBV related hepatocellular carcinomas. Gut 54 (2005) 1162-1168
15. Koike K., Kobayashi M., Mizusawa H., Yoshida E., Yaginuma K., and Taira M. Rearrangement of the surface antigen gene of hepatitis B virus integrated in the human hepatoma cell lines. Nucleic Acids Res 25 (1983) 5391-5402
16. Gunther S., Li B.C., Miska S., Kruger D.H., Meisel H., and Will H. A novel method for efficient amplification of whole hepatitis B virus genomes permits rapid functional analysis and reveals deletion mutants in immunosuppressed patients. J Virol 69 (1995) 5437-5444
17. Okamoto H., Kobata S., Tokita H., Inoue T., Woodfield G.D., Holland P.V., et al. A second-generation method of genotyping hepatitis C virus by the polymerase chain reaction with sense and antisense primers deduced from the core gene. J Virol Methods 57 (1996) 31-45
18. Simmonds P., Alberti A., Alter H.J., Bonino F., Bradley D.W., Brechot C., et al. A proposed system for the nomenclature of hepatitis C viral genotypes. Hepatology 19 (1994) 1321-1324
19. Toyoda H., Kumada T., Kiriyama S., Sone Y., Tanikawa M., Hisanaga Y., et al. Prevalence of low-level hepatitis B viremia in patients with HBV surface antigen-negative hepatocellular carcinoma with and without hepatitis C virus infection in Japan: analysis by COBAS TaqMan real-time PCR. Intervirology 50 (2007) 241-244
20. Tamori A., Nishiguchi S., Kubo S., Narimatsu T., Habu D., Takeda T., et al. HBV DNA integration and HBV-transcript expression in non-B, non-C hepatocellular carcinoma in Japan. J Med Virol 71 (2003) 492-498
21. Brechot C., Gozuacik D., Murakami Y., and Paterlini-Brechot P. Molecular bases for the development of hepatitis B virus (HBV)-related hepatocellular carcinoma (HCC). Semin Cancer Biol 10 (2000) 211-231
22. Hino O., Shows T.B., and Rogler C.E. Hepatitis B virus integration site in hepatocellular carcinoma at chromosome 17;18 translocation. Proc Natl Acad Sci USA 83 (1986) 8338-8342
23. Nakamura T., Tokino T., Nagaya T., and Matsubara K. Microdeletion associated with the integration process of hepatitis B virus DNA. Nucleic Acids Res 16 (1988) 4865-4873
24. Dejean A., Bougueleret L., Grzeschik K.H., and Tiollais P. Hepatitis B virus DNA integration in a sequence homologous to v-erb-A and steroid receptor genes in a hepatocellular carcinoma. Nature 322 (1986) 70-72
25. Wang J., Chenivesse X., Henglein B., and Brechot C. Hepatitis B virus integration in a cyclin A gene in a hepatocellular carcinoma. Nature 343 (1990) 555-557
26. Nagaya T., Nakamura T., Tokino T., Tsurimoto T., Imai M., Mayumi T., et al. The mode of hepatitis B virus DNA integration in chromosomes of human hepatocellular carcinoma. Genes Dev 1 (1987) 773-782
27. Takada S., Gotoh Y., Hayashi S., Yoshida M., and Koike K. Structural rearrangement of integrated hepatitis B virus DNA as well as cellular flanking DNA is present in chronically infected hepatic tissues. J Virol 64 (1990) 822-828
28. Yoshida H., Shiratori Y., Moriyama M., Arakawa Y., Ide T., Sata M., et al. Interferon therapy reduces the risk for hepatocellular carcinoma: national surveillance program of cirrhotic and noncirrhotic patients with chronic hepatitis C in Japan. Ann Int Med 131 (1999) 174-181
29. Tamori A., Nishiguchi S., Shiomi S., Hayashi T., Kobayashi S., Habu D., et al. Hepatitis B virus DNA integration in hepatocellular carcinoma after interferon-induced disappearance of hepatitis C virus. Am J Gastroenterol 100 (2005) 1748-1753
30. Chan H.L., Hui A.Y., Wong M.L., Tse A.M., Hung L.C., Wong V.W., et al. Genotype C hepatitis B virus infection is associated with an increased risk of hepatocellular carcinoma. Gut 53 (2004) 1494-1498
31. Ono Y., Onda H., Sasada H., Igarashi K., Sugino Y., and Nishioka K. The complete nucleotide sequences of the cloned hepatitis B virus DNA; subtype adr and adw. Nucleic Acid Res 11 (1983) 1747-1757
32. Kusano N., Okita K., Shirahashi H., Harada T., Shiraishi K., Oga A., et al. Chromosomal imbalances detected by comparative genomic hybridization are associated with outcome of patients with hepatocellular carcinoma. Cancer 94 (2002) 746-751