Suppression of phosphoenolpyruvate carboxykinase gene expression by reduced endogenous glutathione level

Biochimica et Biophysica Acta - Molecular Basis of Disease

Volumn 1772, Issue 10, 2007, Pages 1175-1181

  Zhang, Jiandi ^a  

^a UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

Author keywords

Ageing and diabetes; Glutathione; Hepatocytes; PEPCK; PI 3 kinase

Indexed keywords

2 MORPHOLINO 8 PHENYLCHROMONE; GLUTATHIONE; PHOSPHOENOLPYRUVATE CARBOXYKINASE (GTP); WORTMANNIN;

AGING; ARTICLE; CELL METABOLISM; CONTROLLED STUDY; ENERGY BALANCE; GENE EXPRESSION; GENE REPRESSION; GLUCONEOGENESIS; HOMEOSTASIS; MALE; NONHUMAN; PRIORITY JOURNAL; RAT;

ACETYLCYSTEINE; AGING; ANIMALS; CELL LINE, TUMOR; DIABETES MELLITUS; DITHIOTHREITOL; ENERGY METABOLISM; ENZYME INHIBITORS; FREE RADICAL SCAVENGERS; GENE EXPRESSION REGULATION, ENZYMOLOGIC; GLUCONEOGENESIS; GLUTATHIONE; HEPATOCYTES; HOMEOSTASIS; MALE; OBESITY; OXIDATION-REDUCTION; P38 MITOGEN-ACTIVATED PROTEIN KINASES; PHOSPHOENOLPYRUVATE CARBOXYKINASE (ATP); RATS; RATS, SPRAGUE-DAWLEY; RNA, MESSENGER;

RATTUS;

EID: 36549049440     PISSN: 09254439     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bbadis.2007.10.001     Document Type: Article

References (22)

1. Harman D. The free radical theory of aging. Antioxid. Redox Signal. 5 (2003) 557-561
2. Droge W. Aging-related changes in the thiol/disulfide redox state: implications for the use of thiol antioxidants. Exp. Gerontol. 37 (2002) 1333-1345
3. Filomeni G., Rotilio G., and Ciriolo M.R. Cell signalling and the glutathione redox system. Biochem. Pharmacol. 64 (2002) 1057-1064
4. Suh J.H., Shenvi S.V., Dixon B.M., Liu H., Jaiswal A.K., Liu R.M., and Hagen T.M. Decline in transcriptional activity of Nrf2 causes age-related loss of glutathione synthesis, which is reversible with lipoic acid. Proc. Natl. Acad. Sci. U. S. A. 101 (2004) 3381-3386
5. Liu H., Wang H., Shenvi S., Hagen T.M., and Liu R.M. Glutathione metabolism during aging and in Alzheimer disease. Ann. N.Y. Acad. Sci. 1019 (2004) 346-349
6. Salazar D.E., Sorge C.L., Jordan S.W., and Corcoran G.B. Obesity decreases hepatic glutathione concentrations and markedly potentiates allyl alcohol-induced periportal necrosis in the overfed rat. Int. J. Obes. Relat. Metab. Disord. 18 (1994) 25-33
7. Maritim A.C., Sanders R.A., and Watkins III J.B. Diabetes, oxidative stress, and antioxidants: a review. J. Biochem. Mol. Toxicol. 17 (2003) 24-38
8. Anderson M.E. Glutathione: an overview of biosynthesis and modulation. Chem. Biol. Interact. 111-112 (1998) 1-14
9. Zhang J. Resveratrol inhibits insulin responses in a SirT1-independent pathway. Biochem. J. 397 (2006) 519-527
10. Zhang J. The direct involvement of SirT1 in insulin-induced IRS-2 tyrosine phosphorylation. J. Biol. Chem. (2007) 10.1074/jbc.M706644200
11. Griffith O.W. Determination of glutathione and glutathione disulfide using glutathione reductase and 2-vinylpyridine. Anal. Biochem. 106 (1980) 207-212
12. Applied Biosystems User Bulletin N0.2, Rev. B, Foster City, CA 94404 2001.
13. Ito Y., Oumi S., Nagasawa T., and Nishizawa N. Oxidative stress induces phosphoenolpyruvate carboxykinase expression in H4IIE cells. Biosci. Biotechnol. Biochem. 70 (2006) 2191-2198
14. Day B.J., Shawen S., Liochev S.I., and Crapo J.D. A metalloporphyrin superoxide dismutase mimetic protects against paraquat-induced endothelial cell injury, in vitro. J. Pharmacol. Exp. Ther. 275 (1995) 1227-1232
15. Hanson R.W., and Reshef L. Regulation of phosphoenolpyruvate carboxykinase (GTP) gene expression. Ann. Rev. Biochem. 66 (1997) 581-611
16. Heilbronn L.K., and Ravussin E. Calorie restriction and aging: review of the literature and implications for studies in humans. Am. J. Clin. Nutr. 78 (2003) 361-369
17. Podolin D.A., Gleeson T.T., and Mazzeo R.S. Hormonal regulation of hepatic gluconeogenesis: influence of age and training. Am. J. Physiol. 270 (1996) R365-R372
18. Hagopian K., Ramsey J.J., and Weindruch R. Influence of age and caloric restriction on liver glycolytic enzyme activities and metabolite concentrations in mice. Exp. Gerontol. 38 (2003) 253-266
19. Van Remmen H., and Ward W.F. Effect of age on induction of hepatic phosphoenolpyruvate carboxykinase by fasting. Am. J. Physiol. 267 (1994) G195-G200
20. Wimonwatwatee T., Heydari A.R., Wu W.T., and Richardson A. Effect of age on the expression of phosphoenolpyruvate carboxykinase in rat liver. Am. J. Physiol. 267 (1994) G201-G204
21. Kamel N.S., Gammack J., Cepeda O., and Flaherty J.H. Antioxidants and hormones as antiaging therapies: high hopes, disappointing results. Clevel. Clin. J. Med. 73 (2006) 1049-1056 [1058]
22. Yabe D., Komuro R., Liang G., Goldstein J.L., and Brown M.S. Liver-specific mRNA for Insig-2 down-regulated by insulin: implications for fatty acid synthesis. Proc. Natl. Acad. Sci. U. S. A. 100 (2003) 3155-3160