Chiral bioanalysis of torcetrapib enantiomers in hamster plasma by normal-phase liquid chromatography and detection by atmospheric pressure chemical ionization tandem mass spectrometry

Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences

Volumn 860, Issue 2, 2007, Pages 227-234

  Trivedi, Ravi Kumar ^a,b   Layek, Buddhadev ^b   Kumar, T Santosh ^b   Vittal, Shivva ^b   Ganneboina, Ramesh ^b   Dubey, P K ^a   Mullangi, Ramesh ^b   Srinivas, Nuggehally R ^b  

^a JNTUH COLLEGE OF ENGINEERING   (India)

^b DR REDDY'S LABORATORIES LTD   (India)

Author keywords

APCI; Chiralpak AD; Enantioselective; LC MS MS; Pharmacokinetics; Plasma; Torcetrapib; Validation

Indexed keywords

ACETONITRILE; ATMOSPHERIC PRESSURE; CHIRALITY; LIQUID CHROMATOGRAPHY; MASS SPECTROMETRY; PHARMACOKINETICS; PLASMA (HUMAN);

CHIRAL LIQUID CHROMATOGRAPHY; ION TRANSITIONS; NORMAL PHASE LIQUID CHROMATOGRAPHY; STEREOSELECTIVE ORAL PHARMACOKINETICS; TORCETRAPIB ENANTIOMERS;

ENANTIOMERS;

ACETONITRILE; TORCETRAPIB;

ACCURACY; ANIMAL EXPERIMENT; AREA UNDER THE CURVE; ARTICLE; CHIRAL CHROMATOGRAPHY; CONTROLLED STUDY; DRUG BLOOD LEVEL; DRUG METABOLISM; DRUG STRUCTURE; ENANTIOMER; LIQUID CHROMATOGRAPHY; MALE; NONHUMAN; PRIORITY JOURNAL; SENSITIVITY AND SPECIFICITY; TANDEM MASS SPECTROMETRY; VALIDATION PROCESS;

ANIMALS; ANTICHOLESTEREMIC AGENTS; ATMOSPHERIC PRESSURE; CALIBRATION; CHROMATOGRAPHY, LIQUID; CRICETINAE; MALE; MESOCRICETUS; QUINOLINES; REFERENCE STANDARDS; REPRODUCIBILITY OF RESULTS; SENSITIVITY AND SPECIFICITY; STEREOISOMERISM; TANDEM MASS SPECTROMETRY;

CRICETINAE;

EID: 36549046928     PISSN: 15700232     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jchromb.2007.10.043     Document Type: Article

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