Development and validation of an enantioselective HPLC-UV method using Chiralpak AD-H to quantify (+)- and (-)-torcetrapib enantiomers in hamster plasma-application to a pharmacokinetic study

Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences

Volumn 857, Issue 2, 2007, Pages 224-230

  Trivedi, Ravi Kumar ^a,b   Dubey, P K ^b   Mullangi, Ramesh ^a   Srinivas, Nuggehally R ^a  

^a DR REDDY'S LABORATORIES LTD   (India)

^b JNTUH COLLEGE OF ENGINEERING   (India)

Author keywords

Chirality; Chiralpak AD H ; Enantioselective; Hamsters; HPLC UV; Pharmacokinetics; Quantitation; Torcetrapib

Indexed keywords

ACETONITRILE; ALCOHOLS; ENANTIOMERS; ENANTIOSELECTIVITY; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; PHASE SEPARATION;

MOBILE PHASE; PLASMA SAMPLES; TORCETRAPIB;

PHARMACOKINETICS;

2 PROPANOL; ACETONITRILE; HEXANE; TORCETRAPIB;

ACCURACY; ANIMAL EXPERIMENT; ARTICLE; CHIRALITY; CONTROLLED STUDY; DEVICE; DRUG BLOOD LEVEL; DRUG RETENTION; ENANTIOMER; ENANTIOSELECTIVITY; EXTRACTION; FLOW RATE; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; LIQUID LIQUID EXTRACTION; MALE; MONITORING; NONHUMAN; PRIORITY JOURNAL; QUALITY CONTROL; SEPARATION TECHNIQUE; TEMPERATURE; ULTRAVIOLET RADIATION; VALIDATION PROCESS;

2-PROPANOL; AMYLOSE; ANIMALS; ANTICHOLESTEREMIC AGENTS; BIOLOGICAL ASSAY; CALIBRATION; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; CRICETINAE; DRUG STABILITY; MALE; MESOCRICETUS; PHENYLCARBAMATES; QUINOLINES; REPRODUCIBILITY OF RESULTS; SPECTROPHOTOMETRY, ULTRAVIOLET; STEREOISOMERISM; TEMPERATURE; TIME FACTORS;

CRICETINAE;

EID: 34548814445     PISSN: 15700232     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jchromb.2007.07.045     Document Type: Article

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