Immunohistochemical expression patterns of AP2α and AP2γ in the developing fetal human breast

Histopathology

Volumn 51, Issue 6, 2007, Pages 814-823

  Friedrichs, N ^a   Steiner, S ^a   Buettner, R ^a   Knoepfle, G ^a  

^a UNIVERSITY OF BONN   (Germany)

Author keywords

AP 2; Development; Fetal breast; Immunohistochemistry; Transcription factor

Indexed keywords

CYTOKERATIN; EPIDERMAL GROWTH FACTOR RECEPTOR; PROTEIN HER 1; SMOOTH MUSCLE ACTIN; TRANSCRIPTION FACTOR AP 2; TRANSCRIPTION FACTOR AP 2ALPHA; TRANSCRIPTION FACTOR AP 2GAMMA; UNCLASSIFIED DRUG;

APOPTOSIS; ARTICLE; BASAL CELL; BREAST DEVELOPMENT; BREAST EPITHELIUM; CELL DIFFERENTIATION; CELL MATURATION; CELL PROLIFERATION; FETUS; FETUS DEVELOPMENT; GESTATIONAL AGE; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; INFANT; MYOEPITHELIUM CELL; NIPPLE; NORMAL HUMAN; PRIMORDIUM; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; STEM CELL;

ACTINS; BIOLOGICAL MARKERS; BREAST; FEMALE; FETUS; GENE EXPRESSION; HUMANS; IMMUNOHISTOCHEMISTRY; INFANT; KERATIN-18; KERATIN-5; MALE; RECEPTOR, ERBB-2; RECEPTORS, ESTROGEN; RECEPTORS, PROGESTERONE; TRANSCRIPTION FACTOR AP-2;

EID: 36549045999     PISSN: 03090167     EISSN: 13652559     Source Type: Journal    
DOI: 10.1111/j.1365-2559.2007.02887.x     Document Type: Article

References (30)

1. Trichopoulos D. Hypothesis: does breast cancer originate in utero? Lancet 1990 335 939 940.
2. Friedrichs N, Jager R, Paggen E et al. Distinct spatial expression patterns of AP-2alpha and AP-2gamma in non-neoplastic human breast and breast cancer. Mod. Pathol. 2005 18 431 438.
3. Hilger-Eversheim K, Moser M, Schorle H, Buettner R. Regulatory roles of AP-2 transcription factors in vertebrate development, apoptosis and cell-cycle control. Gene 2000 260 1 12.
4. Eckert D, Buhl S, Weber S, Jager R, Schorle H. The AP-2 family of transcription factors. Genome Biol. 2005 6 246.
5. Williams T, Tjian R. Characterization of a dimerization motif in AP-2 and its function in heterologous DNA-binding proteins. Science 1991 251 1067 1071.
6. Williams T, Tjian R. Analysis of the DNA-binding and activation properties of the human transcription factor AP-2. Genes Dev. 1991 5 670 682.
7. Turner BC, Zhang J, Gumbs AA et al. Expression of AP-2 transcription factors in human breast cancer correlates with the regulation of multiple growth factors signalling pathways. Cancer Res. 1998 58 5466 5472.
8. Zhang J, Brewer S, Huang J, Williams T. Overexpression of transcription factor Ap-2 alpha suppresses mammary gland growth and morphogenesis. Dev. Biol. 2003 256 127 145.
9. Gee JM, Robertson JF, Ellis IO, Nicholson RI, Hurst HC. Immunohistochemical analysis reveals a tumour suppressor-like role for the transcription factor AP-2 in invasive breast cancer. J. Pathol. 1999 189 514 520.
10. Pellikainen J, Kataja V, Ropponen K et al. Reduced nuclear expression of transcription factor AP-2 associates with aggressive breast cancer. Clin. Cancer Res. 2002 8 3487 3495.
11. Anbazhagan R, Osin PP, Bartkova J, Nathan B, Lane EB, Gusterson BA. The development of epithelial phenotypes in the human fetal and infant breast. J. Pathol. 1998 184 197 206.
12. Jolicoeur F, Gaboury LA, Oligny LL. Basal cells of second trimester fetal breasts: immunohistochemical study of myoepithelial precursors. Pediatr. Dev. Pathol. 2003 6 398 413.
13. Anbazhagan R, Bartek J, Monaghan P, Gusterson BA. Growth and development of the human infant breast. Am. J. Anat. 1991 192 407 417.
14. Keeling JW, Ozer E, King G, Walker F. Oestrogen receptor alpha in female fetal, infant, and child mammary tissue. J. Pathol. 2000 191 449 451.
15. Press MF, Cordon-Cardo C, Slamon DJ. Expression of the HER-2/neu proto-oncogene in normal human adult and fetal tissues. Oncogene 1990 5 953 962.
16. De Potter CR, Van Daele S, Van de Vijver MJ et al. The expression of the neu oncogene product in breast lesions and in normal fetal and adult human tissues. Histopathology 1989 15 351 362.
17. Boecker W, Moll R, Poremba C et al. Common adult stem cells in the human breast give rise to glandular and myoepithelial cell lineages: a new cell biological concept. Lab. Invest. 2002 82 737 745.
18. Boecker W, Buerger H. Evidence of progenitor cells of glandular and myoepithelial cell lineages in the human adult female breast epithelium: a new progenitor (adult stem) cell concept. Cell Prolif. 2003 36 (Suppl. 1 73 84.
19. Boecker W, Moll R, Dervan P et al. Usual ductal hyperplasia of a breast is a committed stem (progenitor) cell lesion distinct from atypical ductal hyperplasia and ductal carcinoma in situ. J. Pathol. 2002 198 458 467.
20. Thomas DB. Do hormones cause breast cancer? Cancer 1984 53 (Suppl. 3 595 604.
21. Schorle H, Meier P, Buchert M, Jaenisch R, Mitchell PJ. Transcription factor AP-2 essential for cranial closure and craniofacial development. Nature 1996 381 235 238.
22. Moser M, Pscherer A, Roth C et al. Enhanced apoptotic cell death of renal epithelial cells in mice lacking transcription factor AP-2beta. Genes Dev. 1997 11 1938 1948.
23. Zhang J, Hagopian-Donaldson S, Serbedzija G et al. Neural tube, skeletal and body wall defects in mice lacking transcription factor AP-2. Nature 1996 381 238 241.
24. Werling U, Schorle H. Transcription factor gene AP-2 gamma essential for early murine development. Mol. Cell. Biol. 2002 22 3149 3156.
25. Jäger R, Werling U, Rimpf S, Jacob A, Schorle H. Transcription factor AP-2gamma stimulates proliferation and apoptosis and impairs differentiation in a transgenic model. Mol. Cancer Res. 2003 1 921 929.
26. Hughes E. The development of the mammary gland. Ann. R. Coll. Surg. Engl. 1949 6 99 119.
27. Jolicoeur F. Intrauterine breast development and the mammary myoepithelial lineage. J. Mammary Gland Biol. Neoplasia 2005 10 199 210.
28. Byrne C, Tainsky M, Fuchs E. Programming gene expression in developing epidermis. Development 1994 120 2369 2383.
29. Santini D, Ceccarelli C, Tardio ML, Taffurelli M, Marrano D. Immunocytochemical expression of epidermal growth factor receptor in myoepithelial cells of the breast. Appl. Immunohistochem. Mol. Morphol. 2002 10 29 33.
30. Wang X, Bolotin D, Chu DH, Polak L, Williams T, Fuchs E. AP-2alpha: a regulator of EGF receptor signaling and proliferation in skin epidermis. J. Cell Biol. 2006 172 409 421.