pH-sensitive film coatings: Towards a better understanding and facilitated optimization

European Journal of Pharmaceutics and Biopharmaceutics

Volumn 68, Issue 1, 2008, Pages 2-10

  Siepmann, F ^a   Wahle, C ^a   Leclercq, B ^b   Carlin, B ^c   Siepmann, J ^a  

^a UNIV LILLE   (France)

^b FMC BioPolymer   (Belgium)

^c FMC CORPORATION   (United States)

Author keywords

Coating; Controlled release; Diffusion; Ethylcellulose; Pellets; pH sensitivity; Polymeric drug delivery systems; Release mechanism; Solid dosage form

Indexed keywords

ALGINIC ACID PROPYLENE GLYCOL ESTER; ETHYL CELLULOSE; POLYMER; PROPYLENE GLYCOL; THEOPHYLLINE;

ARTICLE; CONTROLLED RELEASE FORMULATION; DRUG DELIVERY SYSTEM; DRUG RELEASE; FILM COATING; FLOW KINETICS; PH MEASUREMENT; WATER TRANSPORT;

ALGINATES; CELLULOSE; DELAYED-ACTION PREPARATIONS; DIFFUSION; DRUG CARRIERS; GASTRIC JUICE; HYDROGEN-ION CONCENTRATION; INTESTINAL SECRETIONS; KINETICS; THEOPHYLLINE; WATER;

EID: 36549038999     PISSN: 09396411     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ejpb.2007.03.025     Document Type: Article

References (20)

1. Schultz P., and Kleinebudde P. A new multiparticulate delayed release system. Part I: Dissolution properties and release mechanisms. J. Control. Release 47 (1997) 181-189
2. Schultz P., and Kleinebudde P. A new multiparticulate delayed release system. Part II: Coating formulation and properties of free films. J. Control. Release 47 (1997) 191-199
3. Leopold C.S., and Eikeler D. Basic coating polymers for the colon-specific drug delivery in inflammatory bowel disease. Drug Dev. Ind. Pharm. 26 (2000) 1239-1246
4. Borgquist P., Zackrisson G., Nilsson B., and Axelsson A. Simulation and parametric study of a film-coated controlled-release pharmaceutical. J. Control. Release 80 (2002) 229-245
5. Streubel A., Siepmann J., Dashevsky A., and Bodmeier R. pH-independent release of a weakly basic drug from water-insoluble and -soluble matrix tablets. J. Control. Release 67 (2000) 101-110
6. Amighi K., and Moes A.J. Evaluation of thermal and film forming properties of acrylic aqueous polymer dispersion blends: Application to the formulation of sustained-release film coated theophylline pellets. Drug Dev. Ind. Pharm. 21 (1995) 2355-2569
7. Amighi K., Timmermans J., Puigdevall J., Baltes E., and Moes A.J. Peroral sustained-release film coated pellets as a means to overcome physicochemical and biological drug-related problems. I. In vitro development and evaluation. Drug Dev. Ind. Pharm. 24 (1998) 509-515
8. Munday D.L. Film coated pellets containing verapamil hydrochloride: enhanced dissolution into neutral medium. Drug Dev. Ind. Pharm. 29 (2003) 575-583
9. Dashevsky A., Kolter K., and Bodmeier R. pH-independent release of a basic drug from pellets coated with the extended release polymer dispersion Kollicoat SR 30 D and the enteric polymer dispersion Kollicoat MAE 30 DP. Eur. J. Pharm. Biopharm. 58 (2004) 45-49
10. Siepmann F., Hoffmann A., Leclercq B., Carlin B., and Siepmann J. How to adjust desired drug release patterns from ethylcellulose-coated dosage forms. J. Control Release 119 (2007) 182-189
11. Lecomte F., Siepmann J., Walther M., MacRae R.J., and Bodmeier R. Polymer blends used for the coating of multiparticulates: comparison of aqueous and organic coating techniques. Pharm. Res. 21 (2004) 882-890
12. Chang R.K. A comparison of rheological and enteric properties among organic solutions, ammonium salt aqueous solutions, and latex systems of some enteric polymers. Pharm. Technol. 14 (1990) 62-70
13. Lorck C.A., Grunenberg P.C., Juenger H., and Laicher A. Influence of process parameters on sustained-release theophylline pellets coated with aqueous polymer dispersions and organic solvent-based polymer solutions. Eur. J. Pharm. Biopharm. 43 (1997) 149-157
14. Garcia-Arieta A., Torrado-Santiago D., and Torrado J.J. Comparative study of aqueous and organic enteric coatings of chlorpheniramine maleate tablets. Drug Dev. Ind. Pharm. 22 (1996) 579-585
15. Iyer U., Hong W.H., Das N., and Ghebre-Sellassie I. Comparative evaluation of three organic solvent and dispersion-based ethylcellulose coating formulations. Pharm. Technol. 14 (1990) 68-86
16. Wesseling M., and Bodmeier R. Drug release from beads coated with an aqueous colloidal ethylcellulose dispersion, Aquacoat, or an organic ethylcellulose solution. Eur. J. Pharm. Biopharm. 47 (1999) 33-38
17. McGinity J.W. Aqueous Polymeric Coatings for Pharmaceutical Dosage Forms. second ed. (1997), Marcel Dekker, New York
18. Crank J. The Mathematics of Diffusion (1975), Clarendon Press, Oxford
19. Carslaw H.S., and Jaeger J.C. Conduction of Heat in Solids (1959), Clarendon Press, Oxford
20. Vergnaud J.M. Controlled Drug Release of Oral Dosage Forms (1993), Ellis Horwood, Chichester