Fragrance material review on ethyl salicylate

Food and Chemical Toxicology

Volumn 45, Issue 1 SUPPL., 2007, Pages

  Lapczynski, A ^a   McGinty, D ^a   Jones, L ^a   Bhatia, S ^a   Letizia, C S ^a   Api, A M ^a  

^a RESEARCH INSTITUTE FOR FRAGRANCE MATERIALS   (United States)

Author keywords

Ethyl salicylate; Fragrance; Review

Indexed keywords

FRAGRANCE; SALICYLIC ACID DERIVATIVE; SALICYLIC ACID ETHYL ESTER; UNCLASSIFIED DRUG;

ABSORPTION; CHEMICAL ANALYSIS; CHEMICAL COMPOSITION; DERMATOLOGY; DISEASE MODEL; HUMAN; IN VITRO STUDY; METABOLISM; MUCOSAL DISEASE; NONHUMAN; PHOTOALLERGY; PHOTOTOXICITY; PHYSICAL CHEMISTRY; REVIEW; SKIN IRRITATION; SKIN SENSITIZATION; TOXICOLOGY;

ANIMALS; CONSUMER PRODUCT SAFETY; DOSE-RESPONSE RELATIONSHIP, DRUG; HUMANS; IRRITANTS; PERFUME; RISK ASSESSMENT; SALICYLATES; SKIN; SKIN ABSORPTION; SKIN IRRITANCY TESTS; SKIN TESTS; TOXICITY TESTS;

EID: 36549032140     PISSN: 02786915     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.fct.2007.09.043     Document Type: Review

References (14)

1. Belsito D., Bickers D., Bruze M., Calow P., Greim H., Hanifin J.H., Rogers A.E., Saurat J.H., Sipes I.G., and Tagami H. A Toxicologic and Dermatologic assessment of salicylates when used as fragrance ingredients. Food and Chemical Toxicology 45 1S1 (2007) S318-S361
2. Brown E.W., and Scott W.O. The comparative absorption of certain salicylate esters by the human skin. The Journal of Pharmacology and Experimental Therapeutics 50 (1934) 373-385
3. Council of Europe, 2000. Partial agreement in the social and public health field. Chemically-defined flavouring substances. Group 9.5.13. Esters of Aromatic Acids. Salicylates. P. 407, number 432, Council of Europe Publishing, Strasbourg.
4. FDA (Food and Drug Administration), Code of Federal Regulations, 21 CFR 172.515. Title 21 - Food and Drugs, Volume 3, Chapter I - Food and Drug Administration, Department of Health and Human Services. Part 172 - Food Additives Permitted for Direct Addition to Food for Human Consumption. Subpart F - Flavoring Agents and Related Substances, 515 - Synthetic Flavoring Substances and Adjuvants.
5. FEMA (Flavor Extract Manufacturers Association). Recent progress in the consideration of flavoring ingredients under the Food Additives Amendment 3. GRAS substances. Food Technology 19 2, Part 2 (1965) 151-197
6. Higo N., Sato S., Irie T., and Uekama K. Percutaneous penetration and metabolism of salicylic acid derivatives across hairless mouse skin in diffusion cell in vitro. STP Pharma Sciences 5 (1995) 302-308
7. Houghton E.M. Pharmacology of ethyl salicylate. American Journal of Physiology 13 (1905) 331-340
8. IFRA (International Fragrance Association), 2002. Use Level Survey, April 2002.
9. Ishihara M., Itoh M., Nishimura M., Kinoshita M., Kantoh H., Nogami T., and Yamada K. Closed epicutaneous test. Skin Research 28 Suppl. 2 (1986) 230-240
10. JECFA (Joint Expert Committee on Food Additives), 2001. Safety evaluation of certain food additives. WHO Food Additives Series: 48. Prepared by the fifty seventh meeting of the Joint FAO/WHO Expert Committee on Food Additives (JECFA). World Health Organization, Geneva 2001.
11. RIFM (Research Institute for Fragrance Materials, Inc.), 1976a. Acute toxicity studies in rats, mice, rabbits and guinea pigs. RIFM report number 2019, May 12. (RIFM, Woodcliff Lake, NJ, USA).
12. RIFM (Research Institute for Fragrance Materials, Inc.), 1976b. Report on human maximization studies. RIFM report number 1797, April 9a (RIFM, Woodcliff Lake, NJ, USA).
13. Siddiqi M., and Ritschel W.A. pH-Effects on salicylate absorption through the intact rat skin. Scientia Pharmaceutica 40 (1972) 181-189
14. Yano T., Nakagawa A., Tsuji M., and Noda K. Skin permeability of various non-steroidal anti-inflammatory drugs in man. Life Sciences 39 (1986) 1043-1050