Excretion of ketoprofen and nalbuphine in human milk during treatment of maternal pain after delivery

Therapeutic Drug Monitoring

Volumn 29, Issue 6, 2007, Pages 815-818

  Jacqz Aigrain, Evelyne ^a   Serreau, Raphael ^a   Boissinot, Christine ^a   Popon, Michel ^a   Sobel, Alain ^a   Michel, Jacqueline ^a   Sibony, Oliver ^a  

^a HÔPITAL ROBERT DEBRÉ   (France)

Author keywords

Breast feeding; HPLC; Ketoprofen; Nalbuphine; NSAID; Therapeutic drug monitoring

Indexed keywords

KETOPROFEN; NALBUPHINE;

ADULT; ARTICLE; BREAST FEEDING; BREAST MILK; CLINICAL ARTICLE; DRUG BLOOD LEVEL; DRUG EXCRETION; DRUG MILK LEVEL; FEMALE; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; INFORMED CONSENT; POSTPARTUM PAIN; PRIORITY JOURNAL;

ADULT; ANALGESICS, OPIOID; ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; FEMALE; HUMANS; KETOPROFEN; MILK, HUMAN; NALBUPHINE; PAIN; PARTURITION; POSTPARTUM PERIOD;

EID: 36549019644     PISSN: 01634356     EISSN: None     Source Type: Journal    
DOI: 10.1097/FTD.0b013e31815d0f01     Document Type: Article

References (20)

1. Ito S. Drug therapy for breast-feeding women. N Engl J Med. 2000;343:118-126.
2. Hale TW. Medications and mothers' milk. 10th ed. Amarillo, TX: Pharmacosoft Publishing; 2002.
3. De Graves FJ, Riddell MG, Schumacher J. Ketoprofen concentrations in plasma and milk after intravenous administration in dairy cattle. Am J Vet Res. 1996;57:1031-1033.
4. Pao LH, Hsiong CH, Yoa-Pu HU O, et al. High-performance liquid chromatographic method for the simultaneous determination of nalbuphine and its prodrug, sebacoyl dinalbuphine ester, in dog plasma and application to pharmacokinetic studies in dogs. J Chromatogr B. 2000;746:241-247.
5. Rey E, Serreau R. Medication and breast-feeding. In: Jacqz-Aigrain E, Choonara I, eds. Paediatric Clinical Pharmacology. Taylor and Francis; 2006:349-357.
6. Rorarius MG, Suominen P, Baer GA, et al. Diclofenac and ketoprofen for pain treatment after elective caesarian section. Br J Anesth. 1993;70:293-297.
7. Sunshine A, Zighelboim I, Laska F, et al. A double-blind, parallel comparison of ketoprofen, aspirin, and placebo in patients with postpartum pain. J Clin Pharmacol. 1986;26:706-711.
8. Fletcher D, Negre I, Barbin C, et al. Postoperative analgesia with i.v. propacetamol and ketoprofen combination after disc surgery. Can J Anaesth. 1997;44:479-485.
9. Sunshine A, Olson NZ, Ziglelboim I, et al. Ketoprofen, acetaminophen plus oxycodone, and acetaminophen in the relief of postoperative pain. Clin Pharmacol Ther. 1993;54:546-555.
10. Monrigal C, Jacob JP, Granry JC. Comparison of the analgesic efficacy of nalbuphine and its combination with propacetamol during the immediate postoperative period in gynaecologic-obstetrical surgery. An Fr Anesth Reanim. 1994;13:153-157.
11. American Academy of Pediatrics Committee on Drugs. The transfer of drugs and other chemicals into human milk. Pediatrics. 2001;18:776-789.
12. Lebedevs TH, Wojnar-Horton RE, Yapp P, et al. Excretion of indomethacin in breast milk. Br J Clin Pharmacol. 1991;32:751-754.
13. Wischnick A, Manth SM, Lloyds J, et al. The excretion of ketoroloc into breastmilk after multiple oral dosing. Eur J Clin Pharmacol. 1989;36:521-525.
14. Jamali F, Stevens DR. Naproxen excretion in milk and its uptake by the infant. Drug Intell Clin Pharm. 1983;17:910-911.
15. Weilbert RT, Townsend RJ, Kaiser DG, et al. Lack of ibuprofen secretion in human milk. Clin Pharmacol. 1982;1:457-458.
16. Townsend RJ, Benedetti TJ, Erickson SH, et al. Excretion of ibuprofen into breastmilk. Am J Obstet Gynecol. 1984:149:184-186.
17. Eeg-Olofsson O, Malmros I, Elwin CE, et al. Convulsions in a breast-fed infant after indomethacin. Lancet. 1978;2:215.
18. Wischnik A Wetzelsberger N, Lucker PW. Elimination of nalbuphine in human milk. Arzneimittelforschung. 1988;38:1496-1498.
19. Koren G, Cairns J, Chitayat D, et al. Pharmacogenetics of morphine poisoning in a breastfed neonate of a codeine-prescribed mother. Lancet. 2006;368:704.
20. Rodrigues AD. Impact of CYP2C9 genotype on pharmacokinetics: are all cyclooxygenase inhibitors the same? Drug Metab Dispos. 2005;33:1567-1575.