Studying T-cell repertoire selection using fetal thymus organ culture

Methods in Molecular Biology

Volumn 380, Issue , 2007, Pages 171-184

  Ashton Rickardt, Philip G ^a  

^a NONE

Author keywords

Flow cytometer; FTOC; MHC; Negative selection; Peptide; Positive selection; TAP1; Thymus

Indexed keywords

ANIMAL; ARTICLE; CYTOLOGY; FETUS; FLOW CYTOMETRY; IMMUNOLOGY; METHODOLOGY; ORGAN CULTURE TECHNIQUE; PRENATAL DEVELOPMENT; STROMA CELL; T LYMPHOCYTE; THYMUS;

ANIMALS; FETUS; FLOW CYTOMETRY; ORGAN CULTURE TECHNIQUES; STROMAL CELLS; T-LYMPHOCYTES; THYMUS GLAND;

MUS;

EID: 36549013094     PISSN: 10643745     EISSN: None     Source Type: Book Series    
DOI: 10.1385/1-59745-395-1:171     Document Type: Article

References (14)

1. Zinkernagel, R. M. and Doherty, P. C. (1974) Restriction of in vitro T cell mediated cytotoxicity in lymphocytic choriomeningitis within a syngeneic or semi-allogeneic system. Nature 248, 701-702.
2. Bevan, M. J. (1977) In a radiation chimera, host H-2 antigens determine immune responsiveness of donor cytotoxic cells. Nature 269, 417-418.
3. Schwartz, R. (1989) Acquisition of immunological self-tolerance. Cell 57, 1073-1081.
4. Townsend, A., Ohlen, C., Bastin, J., Ljunggren, H. -G., Foster, L., and Karre, K. (1989) Association of class I major histocompatibility heavy and light chains induced by viral peptides. Nature 340, 443-448.
5. Lo, D. and Sprent, J. (1986) Identity of cells that imprint H-2 restricted T cell specificity in the thymus. Nature 319, 672-675.
6. Teh, H. S., Kisielow, P., Scott, B., et al. (1988) Thymic major histocompatibility complex antigens and the alpha beta T-cell receptor determine the CD4/CD8 phenotype of T cells. Nature 335, 229-233.
7. Van Kaer, L., Ashton-Rickardt, P. G., Ploegh, H. L., and Tonegawa, S. (1992) TAP1 mutant mice are deficient in antigen presentation, surface class I molecules, and CD4-8+ T cells. Cell 71, 1205-1214.
8. Ashton-Rickardt, P. G., Van Kaer, L., Schumacher, T. N., Ploegh, H. L., and Tonegawa, S. (1993) Peptide contributes to the specificity of positive selection of CD8+ T cells in the thymus. Cell 73, 1041-1049.
9. Pircher, H. -P., Burki, K., Lang, R., Hengartner, H., and Zinkemagel, R. M. (1989) Tolerance induction in double specific T cell receptor transgenic mice varies with antigen. Nature 342, 559-561.
10. Ashton-Rickardt, P. G., Bandeira, A., Delaney, J. R., et al. (1994) Evidence for a differential avidity model of T cell selection in the thymus. Cell 76, 651-663.
11. Jenkinson, E. J., Van Ewijk, W., and Owen, J. J. (1981) Major histocompatibility complex antigen expression on the epithelium of the developing thymus in normal and nude mice. J. Exp. Med. 153, 280-292.
12. Pircher, H. -P., Brduscha, K., Steinhoff, U., et al. (1993) Tolerance induction by clonal deletion of CD4+8+ thymocytes in vitro does not require dedicated antigenpresenting cells. Eur. J. Immunol. 28, 669-674.
13. Hu, Q., Bazemore Walker, C. R., Girao, C., et al. (1997) Specific recognition of thymic self-peptides induces the positive selection of cytotoxic T lymphocytes. Immunity 7, 221-231.
14. Pacholczyk, R., Kraj, P., and Ignatowicz, L. (2001) An incremental increase in the complexity of peptides bound to class IIMHC changes the diversity of positively selected alpha beta TCRs. J. Immunol, 166, 2357-2363.