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Volumn 14, Issue 1, 2008, Pages 64-69

Safety of long-acting β-agonists in asthma: A review

Author keywords

Asthma; Long acting 2 agonist; Safety

Indexed keywords

BETA ADRENERGIC RECEPTOR STIMULATING AGENT; BUDESONIDE; CORTICOSTEROID; FLUTICASONE; FLUTICASONE PROPIONATE; FORMOTEROL; PLACEBO; SALMETEROL; STEROID; TRIAMCINALONE; UNCLASSIFIED DRUG;

EID: 36548999382     PISSN: 10705287     EISSN: 15316971     Source Type: Journal    
DOI: 10.1097/MCP.0b013e3282f1980b     Document Type: Review
Times cited : (17)

References (41)
  • 1
    • 0028149416 scopus 로고
    • Risks of salmeterol?
    • Finkelstein FN. Risks of salmeterol? N Engl J Med 1994; 331:1314.
    • (1994) N Engl J Med , vol.331 , pp. 1314
    • Finkelstein, F.N.1
  • 2
    • 33144476873 scopus 로고    scopus 로고
    • Nelson HS, Weiss ST, Bleecker ER, et al. The salmeterol multicenter asthma research trial (SMART, a comparison of usual pharmacotherapy for asthma or usual pharmacotherapy plus salmeterol. Chest 2006; 129:15-26. This article is in large part the catalyst for the black-box warning regarding LABAs. The study was designed to assess the safety of added salmeterol in approximately 60 000 subjects with a history of asthma who had no prior exposure to a LABA in a real-world setting. Investigators obtained only minimal baseline demographics with no monitoring of symptoms, or pulmonary function and no measure of compliance with controller medicine(s, Intervention included the subject being provided with 7 months of study medicine (salmeterol or placebo) and a monthly telephone call to determine whether the subject was still taking the study medication, had made any other changes in asthma medication and whether they he/she experienced a life-threatening asthma episode. Enrollment in th
    • Nelson HS, Weiss ST, Bleecker ER, et al. The salmeterol multicenter asthma research trial (SMART): a comparison of usual pharmacotherapy for asthma or usual pharmacotherapy plus salmeterol. Chest 2006; 129:15-26. This article is in large part the catalyst for the black-box warning regarding LABAs. The study was designed to assess the safety of added salmeterol in approximately 60 000 subjects with a history of asthma who had no prior exposure to a LABA in a real-world setting. Investigators obtained only minimal baseline demographics with no monitoring of symptoms, or pulmonary function and no measure of compliance with controller medicine(s). Intervention included the subject being provided with 7 months of study medicine (salmeterol or placebo) and a monthly telephone call to determine whether the subject was still taking the study medication, had made any other changes in asthma medication and whether they he/she experienced a life-threatening asthma episode. Enrollment in this study was terminated following a planned interim analysis that demonstrated an increase in mortality, especially in the African American subjects.
  • 3
    • 33745306721 scopus 로고    scopus 로고
    • Meta-analysis: Effect of long-acting β-agonists on severe asthma exacerbations and asthma-related deaths
    • Salpeter SR, Buckley NS, Ormiston TM, Salpeter EE. Meta-analysis: effect of long-acting β-agonists on severe asthma exacerbations and asthma-related deaths. Ann Intern Med 2006; 144:904-912.
    • (2006) Ann Intern Med , vol.144 , pp. 904-912
    • Salpeter, S.R.1    Buckley, N.S.2    Ormiston, T.M.3    Salpeter, E.E.4
  • 4
    • 29144531153 scopus 로고    scopus 로고
    • Safety of long-acting beta-agonists: An urgent need to clear the air
    • Martinez F. Safety of long-acting beta-agonists: an urgent need to clear the air. N Engl J Med 2005; 353:2637-2639.
    • (2005) N Engl J Med , vol.353 , pp. 2637-2639
    • Martinez, F.1
  • 5
    • 0013161298 scopus 로고    scopus 로고
    • National Asthma Education and Prevention Program, Publication no. 02-5074. Bethesda, Maryland: National Institutes of Health;
    • National Asthma Education and Prevention Program. Expert panel report: guidelines for the diagnosis and management of asthma. Publication no. 02-5074. Bethesda, Maryland: National Institutes of Health; 2002.
    • (2002) Expert panel report: Guidelines for the diagnosis and management of asthma
  • 6
    • 0003736036 scopus 로고    scopus 로고
    • Publication no. 02-3659. Bethesda, Maryland: National Institutes of Health;, Anon
    • Anon. Global strategy for asthma management and prevention. Publication no. 02-3659. Bethesda, Maryland: National Institutes of Health; 2006.
    • (2006) Global strategy for asthma management and prevention
  • 8
    • 29544438051 scopus 로고    scopus 로고
    • Is there a problem with inhaled long-acting β-adrenergic agonists?
    • Nelson HS. Is there a problem with inhaled long-acting β-adrenergic agonists? J Allergy Clin Immunol 2006; 117:3-16.
    • (2006) J Allergy Clin Immunol , vol.117 , pp. 3-16
    • Nelson, H.S.1
  • 9
    • 0028226021 scopus 로고
    • Reduced protection against exercise induced bronchoconstriction after chronic dosing with salmeterol
    • Ramage BJ, Lipworth CG, Ingram IA, et al. Reduced protection against exercise induced bronchoconstriction after chronic dosing with salmeterol. Respir Med 1994; 88:363-368.
    • (1994) Respir Med , vol.88 , pp. 363-368
    • Ramage, B.J.1    Lipworth, C.G.2    Ingram, I.A.3
  • 10
    • 0032076892 scopus 로고    scopus 로고
    • Effects of treatment with formoterol on bronchoprotection against methacholine
    • Lipworth B, Tan S, Devlin M, et al. Effects of treatment with formoterol on bronchoprotection against methacholine. Am J Med 1998; 104:431-438.
    • (1998) Am J Med , vol.104 , pp. 431-438
    • Lipworth, B.1    Tan, S.2    Devlin, M.3
  • 11
    • 0035888721 scopus 로고    scopus 로고
    • Low dose inhaled budesonide and formoterol in mild persistent asthma: The OPTIMA randomized trial
    • O'Byrne PM, Barnes PJ, Rodriquez-Rotsin R, et al. Low dose inhaled budesonide and formoterol in mild persistent asthma: the OPTIMA randomized trial. Am J Respir Crit Care Med 2001; 164:1192-1197.
    • (2001) Am J Respir Crit Care Med , vol.164 , pp. 1192-1197
    • O'Byrne, P.M.1    Barnes, P.J.2    Rodriquez-Rotsin, R.3
  • 12
    • 0034690661 scopus 로고    scopus 로고
    • Meta-analysis of increased dose of inhaled steroid or addition of salmeterol in symptomatic asthma (MIASMA)
    • Shrewsbury S, Pyke S, Britton M. Meta-analysis of increased dose of inhaled steroid or addition of salmeterol in symptomatic asthma (MIASMA). BMJ 2000; 320:1368-1373.
    • (2000) BMJ , vol.320 , pp. 1368-1373
    • Shrewsbury, S.1    Pyke, S.2    Britton, M.3
  • 13
    • 24744449924 scopus 로고    scopus 로고
    • Moderate dose inhaled corticosteroids plus salmeterol versus higher doses of inhaled corticosteroids in symptomatic asthma
    • Masoli M, Weatherall M, Holt S, Beasley R. Moderate dose inhaled corticosteroids plus salmeterol versus higher doses of inhaled corticosteroids in symptomatic asthma. Thorax 2005; 60:730-734.
    • (2005) Thorax , vol.60 , pp. 730-734
    • Masoli, M.1    Weatherall, M.2    Holt, S.3    Beasley, R.4
  • 14
    • 33644877379 scopus 로고    scopus 로고
    • Combination of inhaled long-acting beta2-agonists and inhaled steroids versus higher dose of inhaled steroids in children and adults with persistent asthma
    • CD005533
    • Greenstone IR, Ni Chromin MN, Masse V, et al. Combination of inhaled long-acting beta2-agonists and inhaled steroids versus higher dose of inhaled steroids in children and adults with persistent asthma. Cochrane Database Syst Rev 2005; CD005533.
    • (2005) Cochrane Database Syst Rev
    • Greenstone, I.R.1    Ni Chromin, M.N.2    Masse, V.3
  • 15
    • 0037247229 scopus 로고    scopus 로고
    • Steroid sparing effects of fluticasone 100 mg and salmeterol 50 mg administered twice daily in a single product in patients previously controlled with fluticasone 250 mg twice daily
    • Busse W, Koenig SM, Oppenheimer J, et al. Steroid sparing effects of fluticasone 100 mg and salmeterol 50 mg administered twice daily in a single product in patients previously controlled with fluticasone 250 mg twice daily. J Allergy Clin Immunol 2003; 111:57-65.
    • (2003) J Allergy Clin Immunol , vol.111 , pp. 57-65
    • Busse, W.1    Koenig, S.M.2    Oppenheimer, J.3
  • 16
    • 0032924959 scopus 로고    scopus 로고
    • The effect of regular inhaled formoterol, budesonide, and placebo on mucosal inflammation and clinical indices in mild asthma
    • Wallin A, Sandstrom T, Soderberg M, et al. The effect of regular inhaled formoterol, budesonide, and placebo on mucosal inflammation and clinical indices in mild asthma. Am J Respir Crit Care Med 1999; 159:79-86.
    • (1999) Am J Respir Crit Care Med , vol.159 , pp. 79-86
    • Wallin, A.1    Sandstrom, T.2    Soderberg, M.3
  • 17
    • 27144535903 scopus 로고    scopus 로고
    • Formoterol attenuates neutrophilic airway inflammation in asthma
    • Maneechotesutwan K, Essilfie-Quaye S, Meah S, et al. Formoterol attenuates neutrophilic airway inflammation in asthma. Chest 2005; 128:1936-1942.
    • (2005) Chest , vol.128 , pp. 1936-1942
    • Maneechotesutwan, K.1    Essilfie-Quaye, S.2    Meah, S.3
  • 18
    • 0032589395 scopus 로고    scopus 로고
    • The long-acting beta2-agonist salmeterol xinafoate: Effects on airway inflammation in asthma
    • Roberts JA, Bradding P, Britten KM, et al. The long-acting beta2-agonist salmeterol xinafoate: effects on airway inflammation in asthma. Eur Respir J 1999; 14:275-282.
    • (1999) Eur Respir J , vol.14 , pp. 275-282
    • Roberts, J.A.1    Bradding, P.2    Britten, K.M.3
  • 19
    • 0033534727 scopus 로고    scopus 로고
    • 2-adrenergic receptor agonists in primary human lung fibroblasts and vascular smooth muscle cells
    • 2-adrenergic receptor agonists in primary human lung fibroblasts and vascular smooth muscle cells. J Biol Chem 1999; 274:1005-1010.
    • (1999) J Biol Chem , vol.274 , pp. 1005-1010
    • Eickelberg, O.1    Roth, M.2    Lorx, R.3
  • 20
    • 33645564704 scopus 로고    scopus 로고
    • Adding salmeterol to inhaled corticosteroid: Long term effects on bronchial inflammation in asthma
    • Koopmans JG, Lutter R, Jansen HM, van der Zee JS. Adding salmeterol to inhaled corticosteroid: long term effects on bronchial inflammation in asthma. Thorax 2006; 61:306-312.
    • (2006) Thorax , vol.61 , pp. 306-312
    • Koopmans, J.G.1    Lutter, R.2    Jansen, H.M.3    van der Zee, J.S.4
  • 21
    • 24944501227 scopus 로고    scopus 로고
    • Formoterol added to low-dose budesonide has no additional anti-inflammatory effect in asthmatic patients
    • Overbeek S, Mulder PG, Baelemans SM. Formoterol added to low-dose budesonide has no additional anti-inflammatory effect in asthmatic patients. Chest 2005; 128:1121-1127.
    • (2005) Chest , vol.128 , pp. 1121-1127
    • Overbeek, S.1    Mulder, P.G.2    Baelemans, S.M.3
  • 22
    • 33745356774 scopus 로고    scopus 로고
    • Control of airway inflammation maintained at a lower steroid dose with 100/50 μg of fluticasone propionate/ salmeterol
    • Jarjour NN, Wilson SJ, Koenig SM, et al. Control of airway inflammation maintained at a lower steroid dose with 100/50 μg of fluticasone propionate/ salmeterol. J Allergy Clin Immunol 2006; 118:44-52.
    • (2006) J Allergy Clin Immunol , vol.118 , pp. 44-52
    • Jarjour, N.N.1    Wilson, S.J.2    Koenig, S.M.3
  • 23
    • 0035938606 scopus 로고    scopus 로고
    • Long-acting B2-agonist monotherapy vs. continued therapy with inhaled corticosteroids in patients with persistent asthma: A randomized controlled trial
    • Lazarus SC, Boushey HA, Fahy JV, et al. Long-acting B2-agonist monotherapy vs. continued therapy with inhaled corticosteroids in patients with persistent asthma: a randomized controlled trial. JAMA 2001; 285:2583-2593.
    • (2001) JAMA , vol.285 , pp. 2583-2593
    • Lazarus, S.C.1    Boushey, H.A.2    Fahy, J.V.3
  • 24
    • 0342419450 scopus 로고    scopus 로고
    • Inhaled corticosteroid reduction and elimination in patients with persistent asthma receiving salmeterol; a randomized controlled trial
    • Lemanske RF, Sorkness CA, Mauger EA, et al. Inhaled corticosteroid reduction and elimination in patients with persistent asthma receiving salmeterol; a randomized controlled trial. JAMA 2001; 285:2594-2603.
    • (2001) JAMA , vol.285 , pp. 2594-2603
    • Lemanske, R.F.1    Sorkness, C.A.2    Mauger, E.A.3
  • 25
    • 0031750702 scopus 로고    scopus 로고
    • Potential masking effects of salmeterol on airway inflammation in asthma
    • McIvor RA, Pizzichini E, Turner MO, et al. Potential masking effects of salmeterol on airway inflammation in asthma. Am J Respir Crit Care Med 1998; 158:924-930.
    • (1998) Am J Respir Crit Care Med , vol.158 , pp. 924-930
    • McIvor, R.A.1    Pizzichini, E.2    Turner, M.O.3
  • 26
    • 0345445601 scopus 로고    scopus 로고
    • Effect of inhaled formoterol and budesonide on exacerbations of asthma. Formoterol and Corticosteroids Establishing Therapy (FACET)
    • Pauwels R, Lofdahl CG, Postma DS, et al. Effect of inhaled formoterol and budesonide on exacerbations of asthma. Formoterol and Corticosteroids Establishing Therapy (FACET). N Engl J Med 1998; 338:1405-1411.
    • (1998) N Engl J Med , vol.338 , pp. 1405-1411
    • Pauwels, R.1    Lofdahl, C.G.2    Postma, D.S.3
  • 27
    • 0032771635 scopus 로고    scopus 로고
    • Exacerbations of asthma. A descriptive study of 425 severe exacerbations
    • Tattersfield AE, Postma DS, Barnes PJ, et al. Exacerbations of asthma. A descriptive study of 425 severe exacerbations. Am J Respir Crit Care Med 1999; 160:594-599.
    • (1999) Am J Respir Crit Care Med , vol.160 , pp. 594-599
    • Tattersfield, A.E.1    Postma, D.S.2    Barnes, P.J.3
  • 28
    • 0027531892 scopus 로고
    • Serevent nationwide surveillance study: Comparison of salmeterol with salbutamol in asthmatic patients who require regular bronchodilator treatment
    • Castle W, Fuller R, Hall J, Palmer J. Serevent nationwide surveillance study: comparison of salmeterol with salbutamol in asthmatic patients who require regular bronchodilator treatment. BMJ 1993; 306:1034-1037.
    • (1993) BMJ , vol.306 , pp. 1034-1037
    • Castle, W.1    Fuller, R.2    Hall, J.3    Palmer, J.4
  • 29
  • 30
    • 33750933351 scopus 로고    scopus 로고
    • Safety and effectiveness of long-acting inhaled-agonist bronchodilators when taken with inhaled corticosteroids
    • Ernst P, McIvor A, Ducharne FM, et al. Safety and effectiveness of long-acting inhaled-agonist bronchodilators when taken with inhaled corticosteroids. Ann Intern Med 2006; 145:692-694.
    • (2006) Ann Intern Med , vol.145 , pp. 692-694
    • Ernst, P.1    McIvor, A.2    Ducharne, F.M.3
  • 31
    • 36549050350 scopus 로고    scopus 로고
    • No increase in asthma-related hospitalizations following the addition of salmeterol to an inhaled corticosteroid in patients with asthma: A meta-analysis
    • Nelson HS, Beasley R, Yancey SW, et al. No increase in asthma-related hospitalizations following the addition of salmeterol to an inhaled corticosteroid in patients with asthma: a meta-analysis. Am J Respir Crit Care Med 2007; 175:A59.
    • (2007) Am J Respir Crit Care Med , vol.175
    • Nelson, H.S.1    Beasley, R.2    Yancey, S.W.3
  • 32
    • 36549031694 scopus 로고    scopus 로고
    • Long-term safety of budesonide/ formoterol pressurized metered-dose inhaler (BUD/FM pMDI) in asthma patients: Adverse events and asthma exacerbations
    • O'Brien CD, Peters SP, Prenner BM, Martin P. Long-term safety of budesonide/ formoterol pressurized metered-dose inhaler (BUD/FM pMDI) in asthma patients: adverse events and asthma exacerbations. Am J Respir Crit Care Med 2007; 175:A188.
    • (2007) Am J Respir Crit Care Med , vol.175
    • O'Brien, C.D.1    Peters, S.P.2    Prenner, B.M.3    Martin, P.4
  • 33
    • 0003083826 scopus 로고
    • cDNA for the human B2-adrenergic receptor: A protein with multiple membrane-spanning domains and encoding by a gene whose chromosomal location is shared with that of the receptor for platelet-derived growth factor
    • Kobilka BK, Dixon RA, Fielle HG, et al. cDNA for the human B2-adrenergic receptor: a protein with multiple membrane-spanning domains and encoding by a gene whose chromosomal location is shared with that of the receptor for platelet-derived growth factor. Proc Natl Acad Sci USA 1987; 84:46-50.
    • (1987) Proc Natl Acad Sci USA , vol.84 , pp. 46-50
    • Kobilka, B.K.1    Dixon, R.A.2    Fielle, H.G.3
  • 34
    • 0028791628 scopus 로고
    • Implications of genetic variability of human B2-adrenergic receptor structure
    • Green SA, Turki J, Hall IP, Ligget SB. Implications of genetic variability of human B2-adrenergic receptor structure. Pulmon Pharmacol 1995; 8:1-10.
    • (1995) Pulmon Pharmacol , vol.8 , pp. 1-10
    • Green, S.A.1    Turki, J.2    Hall, I.P.3    Ligget, S.B.4
  • 35
    • 0031466866 scopus 로고    scopus 로고
    • Association between genetic polymorphisms of the beta 2-adrenoreceptor and response to albuterol in children with and without a history of wheezing
    • Martinez FD, Graves PE, Baldini M, et al. Association between genetic polymorphisms of the beta 2-adrenoreceptor and response to albuterol in children with and without a history of wheezing. J Clin Invest 1997; 100:3184-3188.
    • (1997) J Clin Invest , vol.100 , pp. 3184-3188
    • Martinez, F.D.1    Graves, P.E.2    Baldini, M.3
  • 36
    • 0033915078 scopus 로고    scopus 로고
    • The effect of polymorphisms of the beta2-adrenergic receptor on the response to regular use of albuterol in asthma
    • Israel E, Drazen JM, Liggett SB, et al. The effect of polymorphisms of the beta2-adrenergic receptor on the response to regular use of albuterol in asthma. Am J Respir Crit Care Med 2000; 162:75-80.
    • (2000) Am J Respir Crit Care Med , vol.162 , pp. 75-80
    • Israel, E.1    Drazen, J.M.2    Liggett, S.B.3
  • 37
    • 6944232728 scopus 로고    scopus 로고
    • Use of regularly scheduled albuterol treatment in asthma: Genotype-stratified, randomized, placebo-controlled cross-over trial
    • Israel E, Chinchillli VM, Ford JG, et al. Use of regularly scheduled albuterol treatment in asthma: genotype-stratified, randomized, placebo-controlled cross-over trial. Lancet 2004; 364:1505-1512.
    • (2004) Lancet , vol.364 , pp. 1505-1512
    • Israel, E.1    Chinchillli, V.M.2    Ford, J.G.3
  • 38
    • 0033841788 scopus 로고    scopus 로고
    • Asthma exacerbations during long term agonist use: Influence of β2 adrenoceptor polymorphism
    • Taylor DR, Drazen JM, Herbison GP, et al. Asthma exacerbations during long term agonist use: influence of β2 adrenoceptor polymorphism. Thorax 2000; 55:762-767.
    • (2000) Thorax , vol.55 , pp. 762-767
    • Taylor, D.R.1    Drazen, J.M.2    Herbison, G.P.3
  • 39
    • 33645110637 scopus 로고    scopus 로고
    • B-adrenergic receptor polymorphisms and response to salmeterol
    • Weschsler ME, Lehman E, Lazarus SC, et al. B-adrenergic receptor polymorphisms and response to salmeterol. Am J Respir Crit Care Med 2006; 173:519-526.
    • (2006) Am J Respir Crit Care Med , vol.173 , pp. 519-526
    • Weschsler, M.E.1    Lehman, E.2    Lazarus, S.C.3
  • 40
    • 33749370049 scopus 로고    scopus 로고
    • Salmeterol response is not affected by β2-adrenergic receptor genotype in subjects with persistent asthma
    • Bleecker ER, Yancey SW, Baitinger LA. Salmeterol response is not affected by β2-adrenergic receptor genotype in subjects with persistent asthma. J Allergy Clin Immunol 2006; 118:809-816.
    • (2006) J Allergy Clin Immunol , vol.118 , pp. 809-816
    • Bleecker, E.R.1    Yancey, S.W.2    Baitinger, L.A.3
  • 41
    • 36549033308 scopus 로고    scopus 로고
    • 2-adrenergic receptor variation on the long-term safety of formoterol in combination with budesonide and budesonide alone delivered via one pressurized metered-dose inhaled in patients with moderate to severe asthma
    • 2-adrenergic receptor variation on the long-term safety of formoterol in combination with budesonide and budesonide alone delivered via one pressurized metered-dose inhaled in patients with moderate to severe asthma. Am J Respir Crit Care Med 2007; 175:A59.
    • (2007) Am J Respir Crit Care Med , vol.175
    • Lawrence, R.1    Ambrose, H.2    Goldman, M.3


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