Levosimendan in cardiogenic shock: The magic drug for every patient?

Critical Care Medicine

Volumn 35, Issue 12, 2007, Pages 2862-2864

  Smetana, Peter ^a   Geppert, Alexander ^a  

^a WILHELMINEN HOSPITAL   (Austria)

Author keywords

Acute myocardial infarction; Cardiogenic shock; Revascularization

Indexed keywords

DOBUTAMINE; HYPERTENSIVE AGENT; INOTROPIC AGENT; LEVOSIMENDAN; NITRIC OXIDE SYNTHASE; NORADRENALIN;

ACUTE HEART INFARCTION; BETA ADRENERGIC STIMULATION; BLOOD PRESSURE; CARDIOGENIC SHOCK; EDITORIAL; HEART INDEX; HEART MUSCLE REVASCULARIZATION; HEART OUTPUT; HEMODYNAMICS; HUMAN; HYPOTENSION; MEAN ARTERIAL PRESSURE; MORTALITY; PRIORITY JOURNAL; TACHYCARDIA;

EID: 36448989020     PISSN: 00903493     EISSN: None     Source Type: Journal    
DOI: 10.1097/01.CCM.0000288090.16688.B1     Document Type: Editorial

References (18)

1. Hochman JS, Sleeper LA, Webb JG, et al: Early revascularization in acute myocardial infarction complicated by cardiogenic shock. SHOCK Investigators. Should We Emergently Revascularize Occluded Coronaries for Cardiogenic Shock. N Engl J Med 1999; 341:625-634
2. Webb JG, Lowe AM, Sanborn TA, et al: Percutaneous coronary intervention for cardiogenic shock in the SHOCK trial. J Am Coll Cardiol 2003; 42:1380-1386
3. Nieminen MS, Bohm M, Cowie MR, et al: Executive summary of the guidelines on the diagnosis and treatment of acute heart failure: The Task Force on Acute Heart Failure of the European Society of Cardiology. Eur Heart J 2005; 26:384-416
4. Leier CV, Binkley PF: Parenteral inotropic support for advanced congestive heart failure. Prog Cardiovasc Dis 1998; 41:207-224
5. Schulz R, Rose J, Martin C, et al: Development of short-term myocardial hibernation: Its limitation by the severity of ischemia and inotropic stimulation. Circulation 1993; 88:684-695
6. Alexander JH, Reynolds HR, Stebbins AL, et al: Effect of tilarginine acetate in patients with acute myocardial infarction and cardiogenic shock: The TRIUMPH randomized controlled trial. JAMA 2007; 297:1657-1666
7. Mebazaa A, Nieminen MS, Packer M, et al: Levosimendan vs dobutamine for patients with acute decompensated heart failure: The SURVIVE randomized trial. JAMA 2007; 297:1883-91
8. Hochman JS: Cardiogenic shock complicating acute myocardial infarction: Expanding the paradigm. Circulation 2003; 107:2998-3002
9. Geppert A, Steiner A, Zorn G, et al: Multiple organ failure in patients with cardiogenic shock is associated with high plasma levels of interleukin-6. Crit Care Med 2002; 30:1987-1994
10. Geppert A, Dorninger A, Delle-Karth G, et al: Plasma concentrations of interleukin-6, organ failure, vasopressor support, and successful coronary revascularization in predicting 30-day mortality of patients with cardiogenic shock complicating acute myocardial infarction. Crit Care Med 2006; 34:2035-2042
11. Toller WG, Stranz C: Levosimendan, a new inotropic and vasodilator agent. Anesthesiology 2006; 104:556-569
12. Gross GJ, Peart JN: KATP channels and myocardial preconditioning: An update. Am J Physiol Heart Circ Physiol 2003; 285:H921-H930
13. Moiseyev VS, Poder P, Andrejevs N, et al: Safety and efficacy of a novel calcium sensitizer, levosimendan, in patients with left ventricular failure due to an acute myocardial infarction: A randomized, placebo-controlled, double-blind study (RUSSLAN). Eur Heart J 2002; 23:1422-1432
14. Sonntag S, Sundberg S, Lehtonen LA, et al: The calcium sensitizer levosimendan improves the function of stunned myocardium after percutaneous transluminal coronary angioplasty in acute myocardial ischemia. J Am Coll Cardiol 2004; 43:2177-2182
15. Russ MA, Prondzinsky R, Christoph A, et al: Hemodynamic improvement following levosimendan treatment in patients with acute myocardial infarction and cardiogenic shock. Crit Care Med 2007; 35:2732-2739
16. Delle Karth G, Buberl A, Geppert A, et al: Hemodynamic effects of a continuous infusion of levosimendan in critically ill patients with cardiogenic shock requiring catecholamines. Acta Anaesthesiol Scand 2003; 47:1251-1256
17. Rokyta R Jr, Pechman V: The effects of levosimendan on global haemodynamics in patients with cardiogenic shock. Neuro Endocrinol Lett 2006; 27:121-127
18. Garcia-Gonzalez MJ, Dominguez-Rodriguez A, Ferrer-Hita JJ, et al: Cardiogenic shock after primary percutaneous coronary intervention: Effects of levosimendan compared with dobutamine on haemodynamics. Eur J Heart Fail 2006; 8:723-728