Maternal supplementation with citrulline increases renal nitric oxide in young spontaneously hypertensive rats and has long-term antihypertensive effects

Hypertension

Volumn 50, Issue 6, 2007, Pages 1077-1084

  Koeners, Maarten P ^a   Van Faassen, Ernst E ^b   Wesseling, Sebastiaan ^a   De Sain Van Der Velden, Monique ^a   Koomans, Hein A ^a   Braam, Branko ^c   Joles, Jaap A ^a  

^a UNIVERSITY MEDICAL CENTER UTRECHT   (Netherlands)

^b UTRECHT UNIVERSITY   (Netherlands)

^c UNIVERSITY OF ALBERTA   (Canada)

Author keywords

Amino acids; Citrulline; Developmental plasticity; Electron paramagnetic resonance; Hypertension; NO

Indexed keywords

ARGININE; ARGININOSUCCINATE SYNTHASE; CITRULLINE; NITRIC OXIDE; ORNITHINE;

AMINO ACID SYNTHESIS; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BLOOD PRESSURE; CONTROLLED STUDY; DISEASE COURSE; DRUG EFFECT; FEMALE; GENE EXPRESSION; KIDNEY CORTEX; KIDNEY FUNCTION; LONG TERM CARE; MALE; NONHUMAN; PREGNANCY; PRIORITY JOURNAL; RAT; RENOVASCULAR HYPERTENSION; SUPPLEMENTATION;

AMINO ACID TRANSPORT SYSTEMS, BASIC; AMINO ACIDS; ANIMALS; ANTIHYPERTENSIVE AGENTS; ARGININE; ARGININOSUCCINATE SYNTHASE; BLOOD PRESSURE; CITRULLINE; FEMALE; GENE EXPRESSION PROFILING; KIDNEY; MALE; MATERNAL NUTRITION PHYSIOLOGY; NITRIC OXIDE; NITRIC OXIDE SYNTHASE; PREGNANCY; RATS; RATS, INBRED SHR;

EID: 36448982426     PISSN: 0194911X     EISSN: None     Source Type: Journal    
DOI: 10.1161/HYPERTENSIONAHA.107.095794     Document Type: Article

References (28)

1. Vaziri ND, Rodriguez-Iturbe B. Mechanisms of disease: oxidative stress and inflammation in the pathogenesis of hypertension. Nat Clin Pract Nephrol. 2006;2:582-593.
2. Attia DM, Verhagen AM, Stroes ES, van Faassen EE, Grone HJ, De Kimpe SJ, Koomans HA, Braam B, Joles JA. Vitamin E alleviates renal injury, but not hypertension, during chronic nitric oxide synthase inhibition in rats. J Am Soc Nephrol. 2001;12:2585-2593.
3. Verhagen AM, Attia DM, Koomans HA, Joles JA. Male gender increases sensitivity to proteinuria induced by mild NOS inhibition in rats: role of sex hormones. Am J Physiol Renal Physiol. 2000;279:F664-F670.
4. Zatz R, Baylis C. Chronic nitric oxide inhibition model six years on. Hypertension. 1998;32:958-964.
5. Vaziri ND, Ni Z, Oveisi F. Upregulation of renal and vascular nitric oxide synthase in young spontaneously hypertensive rats. Hypertension. 1998;31:1248-1254.
6. Husson A, Brasse-Lagnel C, Fairand A, Renouf S, Lavoinne A. Argininosuccinate synthetase from the urea cycle to the citrulline-NO cycle. Eur J Biochem. 2003;270:1887-1899.
7. Brosnan ME, Brosnan JT. Renal arginine metabolism discussion 2796S-2797S. J Nutr. 2004;134:2791S-2795S.
8. Jones MR. Free amino acid pools in the spontaneously hypertensive rat: a longitudinal study. J Nutr. 1988;118:579-587.
9. Verrey F, Closs EI, Wagner CA, Palacin M, Endou H, Kanai Y. CATs and HATs: the SLC7 family of amino acid transporters. Pflugers Arch. 2004;447:532-542.
10. Curis E, Nicolis I, Moinard C, Osowska S, Zerrouk N, Benazeth S, Cynober L. Almost all about citrulline in mammals. Amino Acids. 2005;29:177-205.
11. Racasan S, Braam B, van der Giezen DM, Goldschmeding R, Boer P, Koomans HA, Joles JA. Perinatal L-arginine and antioxidant supplements reduce adult blood pressure in spontaneously hypertensive rats. Hypertension. 2004;44:83-88.
12. Racasan S, Braam B, Koomans HA, Joles JA. Programming blood pressure in adult SHR by shifting perinatal balance of NO and reactive oxygen species toward NO: the inverted Barker phenomenon. Am J Physiol Renal Physiol. 2005;288:F626-F636.
13. Vanin AF, Bevers LM, Mikoyan VD, Poltorakov AP, Kubrina LN, van Faassen E. Reduction enhances yields of nitric oxide trapping by iron- diethyldithiocarbamate complex in biological systems. Nitric Oxide. 2007;16:71-81.
14. Komatsu K, Frohlich ED, Ono H, Ono Y, Numabe A, Willis GW. Glomerular dynamics and morphology of aged spontaneously hypertensive rats. Effects of angiotensin-converting enzyme inhibition. Hypertension. 1995;25:207-213.
15. Simon A, Plies L, Habermeier A, Martine U, Reining M, Closs EI. Role of neutral amino acid transport and protein breakdown for substrate supply of nitric oxide synthase in human endothelial cells. Circ Res. 2003;93:813-820.
16. Welch WJ, Tojo A, Lee JU, Kang DG, Schnackenberg CG, Wilcox CS. Nitric oxide synthase in the JGA of the SHR: expression and role in tubuloglomerular feedback. Am J Physiol. 1999;277:F130-F138.
17. Cosentino F, Patton S, d'Uscio LV, Werner ER, Werner-Felmayer G, Moreau P, Malinski T, Luscher TF. Tetrahydrobiopterin alters superoxide and nitric oxide release in prehypertensive rats. J Clin Invest. 1998;101:1530-1537.
18. Hong HJ, Hsiao G, Cheng TH, Yen MH. Supplemention with tetrahydrobiopterin suppresses the development of hypertension in spontaneously hypertensive rats. Hypertension. 2001;38:1044-1048.
19. Chen PY, Sanders PW. L-arginine abrogates salt-sensitive hypertension in Dahl/Rapp rats. J Clin Invest. 1991;88:1559-1567.
20. Koeners MP, Racasan S, Koomans HA, Joles JA, Braam B. Nitric oxide, superoxide and renal blood flow autoregulation in SHR after perinatal L-arginine and antioxidants. Acta Physiol (Oxf). 2007;190:329-338.
21. Alves GM, Barao MA, Odo LN, Nascimento Gomes G, Franco Md Mdo C, Nigro D, Lucas SR, Laurindo FR, Brandizzi LI, Zaladek Gil F. L-Arginine effects on blood pressure and renal function of intrauterine restricted rats. Pediatr Nephrol. 2002;17:856-862.
22. Gil FZ, Lucas SR, Gomes GN, Cavanal Mde F, Coimbra TM. Effects of intrauterine food restriction and long-term dietary supplementation with L-arginine on age-related changes in renal function and structure of rats. Pediatr Res. 2005;57:724-731.
23. Jackson AA, Dunn RL, Marchand MC, Langley-Evans SC. Increased systolic blood pressure in rats induced by a maternal low-protein diet is reversed by dietary supplementation with glycine. Clin Sci (Lond). 2002;103:633-639.
24. Brawley L, Torrens C, Anthony FW, Itoh S, Wheeler T, Jackson AA, Clough GF, Poston L, Hanson MA. Glycine rectifies vascular dysfunction induced by dietary protein imbalance during pregnancy. J Physiol. 2004;554:497-504.
25. Franco Mdo C, Dantas AP, Akamine EH, Kawamoto EM, Fortes ZB, Scavone C, Tostes RC, Carvalho MH, Nigro D. Enhanced oxidative stress as a potential mechanism underlying the programming of hypertension in utero. J Cardiovasc Pharmacol. 2002;40:501-509.
26. Yzydorczyk C, Gobeil F, Jr, Cambonie G, Lahaie I, Le NL, Samarani S, Ahmad A, Lavoie JC, Oligny LL, Pladys P, Hardy P, Nuyt AM. Exaggerated vasomotor response to ANG II in rats with fetal programming of hypertension associated with exposure to a low-protein diet during gestation. Am J Physiol Regul Integr Comp Physiol. 2006;291:R1060-R1068.
27. Osowska S, Duchemann T, Walrand S, Paillard A, Boirie Y, Cynober L, Moinard C. Citrulline modulates muscle protein metabolism in old malnourished rats. Am J Physiol Endocrinol Metab. 2006;291:E582-E586.
28. McMillen IC, Robinson JS. Developmental origins of the metabolic syndrome: prediction, plasticity, and programming. Physiol Rev. 2005;85:571-633.