Micronutrients and T-cell subsets: A comparison between HIV-infected and uninfected, severely malnourished Rwandan children

Annals of Tropical Paediatrics

Volumn 27, Issue 4, 2007, Pages 269-275

  Ndagije, F ^a   Baribwira, C ^b   Coulter, J Brian S ^a  

^a LIVERPOOL SCHOOL OF TROPICAL MEDICINE   (United Kingdom)

^b Butare University Teaching Hospital   (Rwanda)

Author keywords

[No Author keywords available]

Indexed keywords

CD4 ANTIGEN; COPPER; SELENIUM; TRACE ELEMENT; ZINC;

CHILD HEALTH; HUMAN IMMUNODEFICIENCY VIRUS; MALNUTRITION; MULTIVARIATE ANALYSIS; TRACE ELEMENT;

ARTICLE; BLOOD LEVEL; BODY HEIGHT; BODY WEIGHT; CALCULATION; CD4+ T LYMPHOCYTE; CONTROLLED STUDY; COPPER BLOOD LEVEL; CORRELATION ANALYSIS; DISEASE SEVERITY; EDEMA; FEMALE; HUMAN; HUMAN CELL; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; IMMUNE DEFICIENCY; INFANT; LYMPHOCYTE COUNT; MAJOR CLINICAL STUDY; MALE; MALNUTRITION; PRESCHOOL CHILD; RWANDA; SCORING SYSTEM; STATISTICAL SIGNIFICANCE; T LYMPHOCYTE SUBPOPULATION; ZINC BLOOD LEVEL;

ANTHROPOMETRY; CD4 LYMPHOCYTE COUNT; CHILD, PRESCHOOL; COPPER; CROSS-SECTIONAL STUDIES; FEMALE; HIV INFECTIONS; HUMANS; IMMUNE TOLERANCE; INFANT; MALE; MALNUTRITION; MICRONUTRIENTS; SELENIUM; T-LYMPHOCYTE SUBSETS; ZINC;

AFRICA; CENTRAL AFRICA; RWANDA; SUB-SAHARAN AFRICA;

EID: 36448973094     PISSN: 02724936     EISSN: None     Source Type: Journal    
DOI: 10.1179/146532807X245652     Document Type: Article

References (38)

1. Piwoz EG, Preble EA. A review of the literature and recommendations for nutritional care and support in sub-Saharan Africa. Support for Analysis and Research in Africa, SARA/USAID, 2000.
2. de Onis M, Frongillo EA, Blossner M. Is malnutrition declining? An analysis of changes in levels of child malnutrition since 1980. Bull WHO 2000; 78:1222-33.
3. Multiple Indicator Cluster Survey 2000. UNICEF/Government of Rwanda.
4. Rwanda Demographic and Health Survey 1996. USAID/Government of Rwanda.
5. www.census.gov/ipc/hiv/rwanda.pdf, 2002.
6. Semba RD, Tang AM. Micronutrients and pathogenesis of human immunodeficiency virus infection. Br J Nutr 1999; 81:181-9.
7. Kessler L, Daley H, Malenga G, Graham S. The impact of the human immunodeficiency virus type-1 on the management of severe malnutrition in Malawi. Ann Trop Paediatr 2000; 20:50-6.
8. Prazuck T, Tall F, Nacro B, et al. HIV infection and severe malnutrition: a clinical and epidemiological study in Burkina Faso. AIDS 1993; 7:103-8.
9. Ticklay IM, Nathoo KJ, Siziya S, Brady JP. HIV infection in malnourished children in Harare, Zimbabwe. East Afr Med J 1997; 74:217-20.
10. Tang AM, Lanzillotti J, Hendricks K, et al. Micronutrients: current issues for HIV care providers. AIDS 2005; 19:847-61.
11. Rikimaru T, Taniguchi K, Yartey JE, Kennedy DO, Nkrumah FK. Humoral and cell-mediated immunity in malnourished children in Ghana. Eur J Clin Nutr 1998; 52:344-50.
12. Totin D, Ndugwa C, Mmiro F, Perry RT, Brooks Jackson J, Semba RD. Iron deficiency anemia is highly prevalent among human immunodeficient virus-infected and uninfected infants in Uganda. J Nutr 2002; 132:423-9.
13. World Health Organization. Management of Severe Malnutrition: A Manual for Physicians and Other Senior Health Workers. Geneva: WHO, 1999.
14. Handbook on Paediatric AIDS in Africa. ANECCA, 2006. Accessed at ANECCAρcqhc.org
15. www.lhsc.on.ca/lab/metals/sexage.htm, 2005.
16. European Collaborative Study. Age-related standards for total lymphocyte, CD4+ and CD8+ T cell counts in children born in Europe. Pediatr Infect Dis 2005; 24:595-600.
17. Chintu C, Malek A, Nyumbu M, et al. Case definition for paediatric AIDS: the Zambian experience. J STD AIDS 1993; 4:83-5.
18. Mgone CS, Mhalu FS, Shao JF, et al. Prevalence of HIV infection and symtomatology of AIDS in Dar es Salaam, Tanzania. J Acquit Immune Defic Syndr 1991; 4:910-13.
19. Rogerson SR, Gladstone M, Callaghan M, et al. HIV infection among paediatric in-patients in Blantyre, Malawi. Trans R Soc Trop Med Hyg 2004; 98:544-52.
20. Baum MK, Miguez-Burbano MJ, Campa A, Shor-Posner G. Selenium and interleukins in persons infected with human immunodeficiency virus type 1. J Infect Dis 2000; 182 (suppl 1):S69-73.
21. Campa A, Shor-Posner G, Indacochea F, et al. Mortality risk in selenium-deficient HIV-positive children. J Acquir Immune Defic Syndr Hum Rarovirol 1999; 20:508-13.
22. Baum MK, Shor-Posner G, Lai S, et al. High risk of HIV-related mortality is associated with selenium deficiency. J Acquir Immune Defic Syndr Hum Retrovirol 1997; 15:370-4.
23. Sappey C, Legrand-Poels S, Best-Belpomme M, et al. Stimulation of glutathione peroxidase activity decreases HIV type 1 activation after oxidative stress. AIDS Res Human Retrovir 1994; 10:1451-61.
24. Kiremadjian-Schumacher L, Roy M, Wishe HI, Cohen MW, Stotzky G. Supplementation with selenium augments the function of natural killer and lymphokine-activated killer cells. Biol Trace Elem Res 1996; 52:227-39.
25. Allavena C, Dousset B. Relationship of trace elements, immunological markers, and HIV 1 infection progression. Biol Trace Elem Res 1995; 47:133-8.
26. Dworkin BM. Selenium deficiency in HIV infection and the acquired immunodeficiency syndrome (AIDS). Chem Biol Interact 1994; 91:181-6.
27. Tang AM, Graham NMH, Kirby AJ, McCall LD, Willett WC, Saah AJ. Dietary micronutrient intake and risk of progression to acquired immunodeficiency syndrome (AIDS) in human immunodeficiency virus type 1 (HIV-1)-infected homosexual men. Am J Epidemiol 1993; 138:937-51.
28. Charkravarty I, Sinha RK. Prevalence of micronutrient deficiency based on results obtained from national pilot program on control of micronutrient malnutrition. Nutr Rev 2002; 60:S53-8.
29. Golden MH, Golden BE. Effect of zinc supplementation on the dietary intake, rate of weight gain, and energy cost of tissue deposition in children recovering from severe malnutrition. Am J Clin Nutr 1981; 34:900-8.
30. Baum MK, Shor-Posner G, Lu Y, et al. Micronutrients and HIV-1 disease progression. AIDS 1995; 9:1051-6.
31. Mocchegiani E, Muzzioli M, Gaetti R, Veccia S, Viticchi C, Scalise G. Contribution of zinc to reduce CD4+ risk factor for 'severe' infection relapse in aging: parallelism with HIV. Int J Immunopharmacol 1999; 21:271-81.
32. Wellinghausen N, Kern WV, Jochle W, Kern P. Zinc serum level in human immunodeficiency virus-infected patients in relation to immunological status Biol Trace Elem Res 2000; 73:139-49.
33. Bhutta ZA, S, Hidayat A, Black RE, et al. Prevention of diarrhoea and pneumonia by zinc supplementation in children in developing countries: pooled analysis of randomised controlled trials, J Pediatr 1999; 135:689-97.
34. Brooks WA, Santosham M, Naheed A, et al. Effect of weekly zinc supplements on incidence of pneumonia and diarrhoea in children younger than 2 years in urban, low-income Bangladesh: randomised controlled trial. Lancet 2005; 366:999-1003.
35. Bobat R, Coovadia H, Stephen C, et al. Safety and efficacy of zinc supplementation for children with HIV-1 infection in South Africa: a randomised double-blind placebo controlled trial. Lancet 2005; 366:1862-74.
36. Castillo-Duran C, Uauy R. Copper deficiency impairs growth of infants recovering from malnutrition. Am J Clin Nutr 1988; 47:710-14.
37. Moreno T, Artacho R, Navarro M, Perez A, Ruiz-Lopez MD. Serum copper concentration in HIV-infection and relationships with other biochemical indices. Sci Total Environ 1998; 217:21-6.
38. Rousseau MC, Molines C, Moreau J, Delmont J. Influence of highly active antiretroviral therapy on micronutrient profiles in HIV-infected patients. Ann Nutr Metab 2000; 44:212-16.