Pseudoneoplastic lesions of the testis and paratesticular structures

Virchows Archiv

Volumn 451, Issue 6, 2007, Pages 987-997

  Algaba, F ^a,b   Mikuz, G ^c   Boccon Gibod, L ^d   Trias, I ^e   Arce, Y ^a   Montironi, R ^f   Egevad, L ^g   Scarpelli, M ^f   Lopez Beltran, A ^h  

^a FUNDACIÓ PUIGVERT   (Spain)

^b UNIVERSITAT AUTÒNOMA DE BARCELONA   (Spain)

^c INNSBRUCK MEDICAL UNIVERSITY   (Austria)

^d ARMAND TROUSSEAU HOSPITAL   (France)

^e HOSPITAL PLATÓ   (Spain)

^f UNIVERSITÀ POLITECNICA DELLE MARCHE   (Italy)

^g INTERNATIONAL AGENCY FOR RESEARCH ON CANCER   (France)

^h HOSPITAL UNIVERSITARIO REINA SOFÍA   (Spain)

Author keywords

Benign mimics; Paratesticular structures; Pseudotumor; Testis; Tumor like

Indexed keywords

ADENOMATOID TUMOR; CELL PROLIFERATION; DIFFERENTIAL DIAGNOSIS; DISEASE ASSOCIATION; DOPPLER ECHOGRAPHY; EPIDIDYMIS; HUMAN; LEYDIG CELL; MALACOPLAKIA; ORCHIECTOMY; ORCHITIS; POLYORCHIDISM; PRIORITY JOURNAL; PSEUDOTUMOR; RETE TESTIS; REVIEW; ROSAI DORFMAN DISEASE; SARCOIDOSIS; SERTOLI CELL; SPERMATIC CORD; SPERMATOCELE; TESTIS; TESTIS TUMOR;

CHORISTOMA; CYSTS; DIAGNOSIS, DIFFERENTIAL; EPIDIDYMITIS; GRANULOMA, PLASMA CELL; HUMANS; MALE; ORCHITIS; TESTICULAR DISEASES;

EID: 36448932378     PISSN: 09456317     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00428-007-0502-8     Document Type: Review

References (110)

1. Abdou NI, NaPombejara C, Sagawa A, Ragland C, Stechschulte DJ, Nilsson U, Gourley W, Watanabe I, Lindsey NJ, Allen MS (1977) Malakoplakia: evidence for monocyte lysosomal abnormality correctable by cholinergic agonist in vitro and in vivo. N Engl J Med 29(297):1413-1419
2. Agarwal V, Li JK, Bard R (1990) Cystic orchitis: a case report. Human Pathol 21:1080-1082
3. Algaba F, Santaularia JM, Garat JM, Cubells J (1986) Testicular pseudolymphoma. Eur Urol 12:362-363
4. Ameur A, al Bouzidi A, Aqira A, Benomar S, Draoui D (1998) Granulomatous orchitis. A case report and review of the literature. Prog Urol 8:410-412
5. Archimbaud A, Bonvalet D, Levy-Klotz B, Vallet C, Civatte J (1984) Syphilitic orchiepididymitis. Apropos of a pseudotumoral case. Ann Dermatol Venereol 111:169-171
6. Bach AM, Hann LE, Hadar O, Shi W, Yoo HH, Giess CS, Sheinfeld J, Thaler H (2001) Testicular microlithiasis: what is its association with testicular cancer? Radiology 220:70-75
7. Balogh K, Travis WD (1984) The frequency of perineural ductules in vasitis nodosa. Am J Clin Pathol 82:710-713
8. Balogh K, Travis WD (1985) Benign vascular invasion in vasitis nodosa. Am J Clin Pathol 83:426-430
9. Bambirra EA, Andrade Jde S, Bamberg A, de Souza EA, Mitidiero CE, de Souza AF (1986) Testicular schistosomiasis mansoni: a differential diagnostic problem with testicular neoplasias. Am J Trop Med Hyg 35:791-792
10. Begin LR, Frail D, Brzezinski A (1990) Myofibroblastoma of the tunica testis: evolving phase of so-called fibrous pseudotumor? Human Pathol 21:866-868
11. Bolen JW, Hammar SP, McNutt MA (1986) Reactive and neoplastic serosal tissue. A light-microscopic, ultrastructural, and immunocytochemical study. Am J Surg Pathol 10:34-47
12. Brauers A, Striepecke E, Mersdorf A, Sohn M, Fuzesi L (1997) Inflammatory pseudotumor of the epididymis. Eur Urol 32:253-255
13. Casella R, Nudell D, Cozzolino D, Wang H, Lipshultz LI (2002) Primary testicular amyloidosis mimicking tumor in a cryptorchid testis. Urology 59:445
14. Cheng L, Zhang S, MacLennan GT, Poulos CK, Sung MT, Beck SD, Foster RS (2006) Interphase fluorescence in situ hybridization analysis of chromosome 12p abnormalities is useful for distinguishing epidermoid cysts of the testis from pure mature teratoma. Clin Cancer Res 12:5668-5672
15. Chong J, Flynn JT (1998) Spontaneous anticoagulant-induced testicular haemorrhage mimicking a testicular tumour. Br J Urol 81:777
16. Collins DH, Pugh RC (1964) Classification and frequency of testicular tumors. Br J Urol 36(Suppl):1-11
17. Dahl EV, Bahn RC (1962) Aberrant adrenal cortical tissue near the testis in human infants. Am J Pathol 40:587-598
18. Davis JM, Woodroof J, Sadasivan R, Stephens R (1995) Case report: congenital adrenal hyperplasia and malignant Leydig cell tumor. Am J Med Sci 309:63-65
19. Dieckmann KP, Henke RP, Zimmer-Krolzig G (1995) Malacoplakia of the epididymis. Report of a case and review of the literature. Urol Int 55:222-225
20. Doebler RW, Norbut AM (1999) Localized testicular infarction masquerading as a testicular neoplasm. Urology 54:366
21. Dotan ZA, Laufer M, Heldenberg E, Langevitz P, Fridman E, Duvdevani M, Ramon J (2003) Isolated testicular polyarteritis nodosa mimicking testicular neoplasm-long-term follow-up. Urology 62:352
22. Dunner PS, Lipsit ER, Nochomovitz LE (1982) Epididymal sperm granuloma simulating a testicular neoplasm. J Clin Ultrasound 10(7):353-355
23. Einstein DM, Paushter DM, Singer AA, Thomas AJ, Levin HS (1992) Fibrotic lesions of the testicle: sonographic patterns mimicking malignancy. Urol Radiol 14:205-210
24. Evans KJ, Teddi RJ, Weatherby E (1985) Spontaneous intratesticular hemorrhage masquerading as a testis tumor. J Urol 134:1211
25. Fernandopulle SM, Hwang JS, Kuick CH, Lui J, Tan PH, Siow WY, Wong M (2006) Rosai-Dorfman disease of the testis: an unusual entity that mimics testicular malignancy. J Clin Pathol 59(3):325-327
26. Ferro F, Lais A, Boldrini R, De Peppo F, Federici G, Bosman C (1996) Hepatogonadal fusion. J Pediatr Surg 31:435-436
27. Fridman E, Skarda J, Ofek-Moravsky E, Cordoba M (2005) Complex multilocular cystic lesion of rete testis, accompanied by smooth muscle hyperplasia, mimicking intratesticular Leydig cell neoplasm. Virchows Arch 447(4):768-771
28. Friedman MT, Gentile P, Tarectecan A, Fuchs A (1996) Malignant mesothelioma: immunohistochemistry and DNA ploidy analysis as methods to differentiate mesothelioma from benign reactive mesothelial cell proliferation and adenocarcinoma in pleural and peritoneal effusions. Arch Pathol Lab Med 120(10):959-966
29. Garat JM, Algaba F, Parra L, Gomez L (1991) Meconium vaginalitis. Br J Urol 68:430-431
30. Gouw AS, Elema JD, Bink-Boelkens MT, de Jongh HJ, ten Kate LP (1985) The spectrum of splenogonadal fusion. Case report and review of 82 reported cases. Eur J Pediatr 144:316-323
31. Green WO Jr (1968) Malacoplakia of the epididymis (without testicular involvement). The first reported case. Arch Pathol 86:438-441
32. Haas GP, Shumaker BP, Cerny JC (1986) The high incidente of benign testicular tumors. J Urol 136:1219-1220
33. Hamm B, Fobbe F, Loy V (1988) Testicular cysts: differentiation with US and clinical findings. Radiology 168(1):19-23
34. Handelsman DJ, Yue DK, Turtle JR (1983) Hypogonadism and massive testicular infiltration due to amyloidosis. J Urol 129(3):610-612
35. Hartwick RW, Ro JY, Srigley JR, Ordonez NG, Ayala AG (1991) Adenomatous hyperplasia of the rete testis. A clinicopathologic study of nine cases. Am J Surg Pathol 15:350-357
36. Hirschowitz L, Rode J, Guillebaud J, Bounds W, Moss E (1988) Vasitis nodosa and associated clinical findings. J Clin Pathol 41(4):419-423
37. Hollowood K, Fletcher CD (1992) Pseudosarcomatous myofibroblastic proliferations of the spermatic cord ("proliferative funiculitis"). Histologic and immunohistochemical analysis of a distinctive entity. Am J Surg Pathol 16(5):448-454
38. Honore LH (1978) Nonspecific peritesticular fibrosis manifested as testicular enlargement. Clinicopathological study of nine cases. Arch Surg 113:814-816
39. Hurd DS, Olsen T (2000) Cutaneous sarcoidosis presenting as a testicular mass. Cutis 66:435-438
40. Iczkowski KA, Butler SL (2006) New immunohistochemical markers in testicular tumors. Anal Quant Cytol Histol 28:181-187
41. Imperial SL, Sidhu JS (2002) Nonseminomatous germ cell tumor arising in splenogonadal fusion. Arch Pathol Lab Med 126:1222-1225
42. Jani AN, Casibang V, Mufarrij WA (1990) Disseminated actinomycosis presenting as a testicular mass: a case report. J Urol 143:1012-1014
43. Joudi FN, Austin JC, Vogelgesang SA, Jensen CS (2004) Isolated testicular vasculitis presenting as a tumor-like lesion. J Urol 171(2 Pt 1):799
44. Kao HW, Wu CJ, Chen CY, Sun GH, Lee SS, Peng YJ (2005) Malignant tumor of testis imitating epididymo-orchitis. Arch Androl 51:407-411
45. Kariv R, Sidi Y, Gur H (2000) Systemic vasculitis presenting as a tumorlike lesion. Four case reports and an analysis of 77 reported cases. Medicine (Baltimore) 79:349-359
46. Katergiannakis V, Lagoudianakis EE, Markogiannakis H, Manouras A (2006) Huge epidermoid cyst of the spermatic cord in an adult patient. Int J Urol 13:95-97
47. Khalil KH, Ball RY, Eardley I, Ashken MH (1996) Inflammatory pseudotumor of the rete testis. J Urol Pathol 5:39-43
48. Knudsen JL, Savage A, Mobb GE (1991) The testicular 'tumour' of adrenogenital syndrome-a persistent diagnostic pitfall. Histopathology 19:468-470
49. Kocak I, Dundar M, Culhaci N, Unsal A (2004) Relapse of brucellosis simulating testis tumor. Int J Urol 11:683-685
50. Lai FM, Allen PW, Chan LW, Chan PS, Cooper JE, Mackenzie TM (1995) Aggressive fibromatosis of the spermatic cord. A typical lesion in a "new" location. Am J Clin Pathol 104(4):403-407
51. Lam KY, Chan KW, Ho MH (1995) Inflammatory pseudotumour of the epididymis. Br J Urol 75:255-257
52. Lee LY, Tzeng J, Grosman M, Unger PD (2004) Prostate gland-like epithelium in the epididymis: a case report and review of the literature. Arch Pathol Lab Med 128:60-62
53. Li M, Fogarty J, Whitney KD, Stone P (2003) Repeated testicular infarction in a patient with sickle cell disease: a possible mechanism for testicular failure. Urology 62:551
54. Maizlin ZV, Belenky A, Baniel J, Gottlieb P, Sandbank J, Strauss S (2005) Epidermoid cyst and teratoma of the testis: sonographic and histologic similarities. J Ultrasound Med 24:1403-1409
55. McCluggage WG, Shah V, Nott C, Clements B, Wilson B, Hill CM (1996) Cystadenoma of spermatic cord resembling ovarian serous epithelial tumour of low malignant potential: immunohistochemical study suggesting Mullerian differentiation. Histopathology 28:77-80
56. McClure J (1980) Malakoplakia of the testis and its relationship to granulomatous orchitis. J Clin Pathol 33:670-678
57. Mikuz G (1973) Ultrastructural study of two cases of granulomatous orchitis. Virchows Arch A 360:223-234
58. Milanezi MF, Schmitt F (1997) Pseudosarcomatous myofibroblastic proliferation of the spermatic cord (proliferative funiculitis). Histopathology 31:387-388
59. Mori H, Tamai M, Fushimi H, Fukuda H, Maeda T (1987) Leydig cells within the aspermatogenic seminiferous tubules. Human Pathol 18:1227-1231
60. Murray RS, Keeling JW, Ellis PM, FitzPatrick DR (2002) Symmetrical upper limb peromelia and lower limb phocomelia associated with a de novo apparently balanced reciprocal translocation: 44,XX,t(2; 12)(p25.1;q24.1). Clin Dysmorph 11:87-90
61. Nativ O, Mor Y, Nass D, Leibovitch I, Goldwasser B (1995) Cholesterol granuloma of the tunica vaginalis mimicking a neoplasm. Isr J Med Sci 31:235-236
62. Naughton CK, Nadler RB, Basler JW, Humphrey PA (1998) Leydig cell hyperplasia. Br J Urol 81:282-289
63. Nistal M, Castillo MC, Regadera J, Garcia-Cabezas MA (2003) Adenomatous hyperplasia of the rete testis. A review and report of new cases. Histol Histopathol 18(3):741-752
64. Nistal M, Gonzalez-Peramato P, Serrano A, Regadera J (2004) Xanthogranulomatous funiculitis and orchiepididymitis: report of 2 cases with immunohistochemical study and literature review. Arch Pathol Lab Med 128:911-914
65. Nistal M, Iniguez L, Paniagua R (1987) Histological classification of spermatic cord cysts in relation to their histogenesis. Eur Urol 13:327-330
66. Nistal M, Paniagua R (1979) Histogenesis of human extraparenchymal Leydig cells. Acta Anat (Basel) 105:188-197
67. Nistal M, Paniagua R, Leon L, Regadera J (1985) Ectopic seminiferous tubules in the tunica albuginea of normal and dysgenetic testes. Appl Pathol 3:123-128
68. Nistal M, Regadera J, Paniagua R (1984) Cystic dysplasia of the testis. Light and electron microscopic study of three cases. Arch Pathol Lab Med 108:579-583
69. Older RA, Watson LR (1994) Tubular ectasia of the rete testis: a benign condition with a sonographic appearance that may be misinterpreted as malignant. J Urol 152(2 Pt 1):477-478
70. Osca Garcia JM, Alfaro Ferreres L, Ruiz Cerda JL, Moreno Pardo B, Martinez Jabaloyas J, Jimenez Cruz JF (1993) Idiopathic granulomatous orchitis. Actas Urol Esp 17:53-56
71. Parveen T, Fleischmann J, Petrelli M (1992) Benign fibrous tumor of the tunica vaginalis testis. Report of a case with light, electron microscopic, and immunocytochemical study, and review of the literature. Arch Pathol Lab Med 116:277-280
72. Pekindil G, Huseyin Atakan I, Kaya E, Bilgi S, Inci O (1999) Bilateral synchronous granulomatous orchitis: gray-scale and colour Doppler sonographic findings. Eur J Radiol 31:201-203
73. Perez-Ordonez B, Srigley JR (2000) Mesothelial lesions of the paratesticular region. Semin Diagn Pathol 17:294-306
74. Poster RB, Spirt BA, Tamsen A, Surya BV (1991) Complex tunica albuginea cyst simulating an intratesticular lesion. Urol Radiol 13:129-132
75. Ralph DJ, Lynch MJ, Pryor JP (1993) Vasitis nodosa due to torture. Br J Urol 72:515-516
76. Ramaswamy G, Jagadha V, Tchertkoff V (1985) A testicular tumor resembling the sex cord with annular tubules in a case of the androgen insensitivity syndrome. Cancer 55:1607-1611
77. Ricco R, Bufo P (1980) Histologic study of 3 cases of so-called tubular adenoma of the testis. Boll Soc Ital Biol Sper 56:2110-2115
78. Rich MA, Keating MA, Levin HS, Kay R (1998) Tumors of the adrenogenital syndrome: an aggressive conservative approach. J Urol 160:1838-1841
79. Rifkin MD, Kurtz AB, Pasto ME, Goldberg BB (1983) Polyorchidism diagnosed preoperatively by ultrasonography. J Ultrasound Med 2:93-94
80. Rosai J, Dehner LP (1975) Nodular mesothelial hyperplasia in hernia sacs: a benign reactive condition simulating a neoplastic process. Cancer 35:165-175
81. Ruibal M, Quintana JL, Fernández G, Zungri E (2003) Segmental testicular infarction. J Urol 170:187-188
82. Rutgers JL, Scully RE (1991) The androgen insensitivity syndrome (testicular feminization): a clinicopathologic study of 43 cases. Int J Gynecol Pathol 10:126-144
83. Ryan DM, Lesser BA, Crumley LA, Cartwright HA, Peron S, Haas GP, Bower G (1993) Epididymal sarcoidosis. J Urol 149:134-136
84. Ryan SP, Harte PJ (1988) Suppurative inflammation of vas deferens: an unusual groin mass. Urology 31:245-246
85. Salako AA, Olasode BJ, Eziyi AK, Osasan SA (2006) Xanthogranulomatous orchitis in an adult Nigerian. Int J Urol 13:186-188
86. Sanders LM, Levy HM, Premkumar A (1988) Malignant mixed germ cell tumor of the testis mimicking a hematocele. Am J Roentgenol 151:1253
87. Saw KC, Hartfall WG, Rowe RC (1993) Tuberculous prostatitis: nodularity may simulate malignancy. Br J Urol 72:249
88. Schned AR, Selikowitz SM (1986) Epididymitis nodosa. An epididymal lesion analogous to vasitis nodosa. Arch Pathol Lab Med 110:61-64
89. Shamsa A, Kadkhodayan A, Feiz-zadeh B, Rasulian H (2002) Testicular hematocele mimicking a testicular tumor: a case report and review of literature. Transplant Proc 34:2141-2142
90. Shawker TH, Doppman JL, Choyke PL, Feuerstein IM, Nieman LK (1992) Intratesticular masses associated with abnormally functioning adrenal glands. J Clin Ultrasound 20:51-58
91. Shekarriz M, Schneider C, Sabanegh E, Kempter F, Waldherr R (1996) Excessive testosterone production in a patient with Nelson syndrome and bilateral testicular tumors. Urol Int 56:200-203
92. Shintaku M, Ukikusa M (2003) Proliferative funiculitis with a prominent infiltration of mast cells. Pathol Int 53:897-900
93. Srigley JR, Hartwick RW (1990) Tumors and cysts of the paratesticular region. Pathol Annu 1968(25 Pt 2):51-108
94. Sundaram S, Smith DH (2001) Giant cell arteritis mimicking a testicular tumour. Rheumatol Int 20:215-216
95. Tank ES, Forsyth M (1988) Splenic gonadal fusion. J Urol 139:798-799
96. Thompson JE, van der Walt JD (1986) Nodular fibrous proliferation (fibrous pseudotumour) of the tunica vaginalis testis. A light, electron microscopic and immunocytochemical study of a case and review of the literature. Histopathology 10:741-748
97. Tolhurst SR, Lotan T, Rapp DE, Lyon MB, Orvieto MA, Gerber GS, Sokoloff MH (2006) Well-differentiated papillary mesothelioma occurring in the tunica vaginalis of the testis with contralateral atypical mesothelial hyperplasia. Urol Oncol 24:36-39
98. Tyagi G, Munn CS, Kiser LC, Wetzner SM, Tarabulcy E (1989) Malignant mesothelioma of tunica vaginalis testis. Urology 34:102-104
99. Ulbright TM, Gersell DJ (1991) Rete testis hyperplasia with hyaline globule formation. A lesion simulating yolk sac tumor. Am J Surg Pathol 15:66-74
100. Vaidyanathan S, Mansour P, Parsons KF, Singh G, Soni BM, Subramaniam R, Oo T, Sett P (2000) Xanthogranulomatous funiculitis and epididymo-orchitis in a tetraplegic patient. Spinal Cord 38:769-772
101. Val-Bernal JF, Val D, Garijo MF (2006) Ectopic epididymal tissue in appendix testis. Virchows Arch 449:373-375
102. Vaos G, Zavras N, Boukouvalea I (2006) Ectopic adrenocortical tissue along the inguinoscrotal path of children. Int Surg 91:125-128
103. Warfield AT, Lee SJ, Phillips SM, Pall AA (1994) Isolated testicular vasculitis mimicking a testicular neoplasm. J Clin Pathol 47:1121-1123
104. Warner JJ, Kirchner FK Jr, Wong SW, Dao AH (1983) Vasitis nodosa presenting as a mass of the spermatic cord. J Urol 129:380-381
105. Wegner HE, Herbst H, Dieckmann KP (1994) Paratesticular epidermoid cyst and ipsilateral spermatic cord dermoid cyst: case report and discussion of pathogenesis, diagnosis and treatment. J Urol 152:2101-2103
106. Wiesenthal JD, Ettler H, Razvi H (2004) Testicular epidermoid cyst: a case report and review of the clinicopathologic features. Can J Urol 11:2133-2135
107. Williams HJ, Abernethy LJ, Losty PD, Kotiloglu E (2004) Meconium periorchitis-a rare cause of a paratesticular mass. Pediatr Radiol 34:421-423
108. Woodward PJ, Schwab CM, Sesterhenn IA (2003) From the archives of the AFIP: extratesticular scrotal masses: radiologic-pathologic correlation. Radiographics 23:215-240
109. Woodward PJ, Sohaey R, O'Donoghue MJ, Green DE (2002) From the archives of the AFIP: tumors and tumorlike lesions of the testis: radiologic-pathologic correlation. Radiographics 22:189-216
110. Yap RL, Jang TL, Gupta R, Pins MR, Gonzalez CM (2004) Xanthogranulomatous orchitis. Urology 63:176-177