Acquisition of loss of the wild-type NRAS locus with aggressive disease progression in a patient with juvenile myelomonocytic leukemia and a heterozygous NRAS mutation

Haematologica

Volumn 92, Issue 11, 2007, Pages 1576-1578

  Matsuda, Kazuyuki ^a   Nakazawa, Yozo ^b   Sakashita, Kazuo ^b   Shiohara, Masaaki ^b   Yamauchi, Kazuyoshi ^a   Koike, Kenichi ^b  

^a SHINSHU UNIVERSITY HOSPITAL   (Japan)

^b SHINSHU UNIVERSITY SCHOOL OF MEDICINE   (Japan)

Author keywords

Blastic crisis; JMML; LOH; Mitotic recombination; NRAS mutation

Indexed keywords

MERCAPTOPURINE;

ARTICLE; BLAST CELL CRISIS; CASE REPORT; CODON; DISEASE COURSE; FLUORESCENCE IN SITU HYBRIDIZATION; GENE; GENE LOCUS; HETEROZYGOSITY; HOMOZYGOSITY; HUMAN; INFANT; JUVENILE MYELOMONOCYTIC LEUKEMIA; MALE; MICROSATELLITE MARKER; MITOGENESIS; NRAS GENE; WILD TYPE;

DISEASE PROGRESSION; GENES, RAS; HETEROZYGOTE; HUMANS; INFANT; LEUKEMIA, MYELOMONOCYTIC, JUVENILE; MALE; MUTATION;

EID: 36349016067     PISSN: 03906078     EISSN: None     Source Type: Journal    
DOI: 10.3324/haematol.11503     Document Type: Article

References (10)

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