Effect of slow-release 5-fluorouracil on capsule formation around silicone breast implants: An experimental study with mice

Aesthetic Plastic Surgery

Volumn 31, Issue 6, 2007, Pages 674-679

  Ibrahim Canter, Halil ^a,c   Konas, Ersoy ^a   Bozdogan, Onder ^b   Vargel, Ibrahim ^b   Ozbatir, Bilgen ^a   Oner, Filiz ^a   Erk, Yucel ^a  

^a HACETTEPE UNIVERSITY   (Turkey)

^b KIRIKKALE UNIVERSITY   (Turkey)

^c PROVIDENCE HOSPITAL   (United States)

Author keywords

5 Fluorouracil; Capsule formation; Collagen synthesis; Silicone breast implant

Indexed keywords

FLUOROURACIL; GELATIN; SILICONE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BREAST ENDOPROSTHESIS; BREAST SURGERY; COLLAGEN SYNTHESIS; CONTRACTURE; CONTROLLED STUDY; DRUG DOSE COMPARISON; DRUG MECHANISM; HISTOPATHOLOGY; INHIBITION KINETICS; MASTITIS; MOUSE; NONHUMAN; PRIORITY JOURNAL; SLOW DRUG RELEASE; ULTRAVIOLET SPECTROPHOTOMETRY;

ANIMALS; ANTIMETABOLITES; BREAST IMPLANTS; COLLAGEN; DOSE-RESPONSE RELATIONSHIP, DRUG; DOWN-REGULATION; EXTRACELLULAR MATRIX PROTEINS; FEMALE; FIBROBLASTS; FLUOROURACIL; FOREIGN-BODY REACTION; IMPLANTS, EXPERIMENTAL; MICE; SILICONE GELS; WOUND HEALING;

EID: 36349009268     PISSN: 0364216X     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00266-006-0172-y     Document Type: Article

References (25)

1. Adams WP Jr, Haydon MS, Raniere J Jr, Trott S, Marques M, Feliciano M, Robinson JB Jr, Tang L, Brown SA: A rabbit model for capsular contracture: Development and clinical implications. Plast Reconstr Surg 117:1214-1219, 2006
2. Akali A, Khan U, Khaw PT, McGrouther AD: Decrease in adhesion formation by a single application of 5-fluorouracil after flexor tendon injury. Plast Reconstr Surg 103:151-158, 1999
3. Baker JL Jr, Chandler ML, LeVier RR: Occurrence and activity of myofibroblasts in human capsular tissue surrounding mammary implants. Plast Reconstr Surg 68:905-912, 1981
4. Bender RA, Zwelling LA, Doroshow JH, Locker GY, Hande KR, Murinson DS, Cohen M, Myers CE, Chabner BA: Antineoplastic drugs: Clinical pharmacology and therapeutic use. Drugs 16:46-87, 1978
5. Bucky LP, Ehrlich HP, Sohoni S, May JW Jr: The capsule quality of saline-filled smooth silicone, textured silicone, and polyurethane implants in rabbits: A long-term study. Plast Reconstr Surg 93:1123-1131, 1994
6. Bulstrode NW, Mudera V, McGrouther DA, Grobbelaar AO, Cambrey AD: 5-fluorouracil selectively inhibits collagen synthesis. Plast Reconstr Surg 116:209-221, 2005
7. Clugston PA, Perry LC, Hammond DC, Maxwell GP: A rat model for capsular contracture: The effects of surface texturing. Ann Plast Surg 33:595-599, 1994
8. Coleman DJ, Foo IT, Sharpe DT: Textured or smooth implants for breast augmentation? A prospective controlled trial. Br J Plast Surg 44:444-448, 1991
9. De Cholnoky T: Augmentation mammaplasty: Survey of complications in 10,941 patients by 265 surgeons. Plast Reconstr Surg 45:573-577, 1970
10. Domanskis E, Owsley JQ Jr: Histological investigation of the etiology of capsule contracture following augmentation mammaplasty. Plast Reconstr Surg 58:689-693, 1976
11. Fitzpatrick RE: Treatment of inflamed hypertrophic scars using intralesional 5-FU. Dermatol Surg 25:224-232, 1999
12. Frangou J, Kanellaki M: The effect of local application of mitomycin-C on the development of capsule around silicone implants in the breast: An experimental study in mice. Aesth Plast Surg 25:118-128, 2001
13. Kamel M, Protzner K, Fornasier V, Peters W, Smith D, Ibanez D: The peri-implant breast capsule: An immunophenotypic study of capsules taken at explantation surgery. J Biomed Mater Res 58:88-96, 2001
14. Khaw PT, Sherwood MB, MacKay SL, Rossi MJ, Schultz G: Five-minute treatments with fluorouracil, floxuridine, and mitomycin have long-term effects on human Tenon's capsule fibroblasts. Arch Ophthalmol 110:1150-1154, 1992
15. Lebwohl M: From the literature: Intralesional 5-FU in the treatment of hypertrophic scars and keloids: Clinical experience. J Am Acad Dermatol 42:67, 2000
16. Manuskiatti W, Fitzpatrick RE: Treatment response of keloidal and hypertrophic sternotomy scars: Comparison among intralesional corticosteroid, 5-fluorouracil, and 585-nm flashlamp-pumped pulsed-dye laser treatments. Arch Dermatol 138:1149-1155, 2002
17. Moran SL, Ryan CK, Orlando GS, Pratt CE, Michalko KB: Effects of 5-fluorouracil on flexor tendon repair. J Hand Surg Am 25:242-251, 2000
18. Occleston NL, Daniels JT, Tarnuzzer RW, Sethi KK, Alexander RA, Bhattacharya SS, Schultz GS, Khaw PT: Single exposures to antiproliferatives: Long-term effects on ocular fibroblast wound-healing behavior. Invest Ophthalmol Vis Sci 38:1998-2007, 1997
19. Ophir A, Ticho U: A randomized study of trabeculectomy and subconjunctival administration of fluorouracil in primary glaucomas. Arch Ophthalmol 110:1072-1075, 1992
20. Ragoowansi R, Khan U, Brown RA, McGrouther DA: Reduction in matrix metalloproteinase production by tendon and synovial fibroblasts after a single exposure to 5-fluorouracil. Br J Plast Surg 54:283-287, 2001
21. Rudolph R, Abraham J, Vecchione T, Guber S, Woodward M: Myofibroblasts and free silicon around breast implants. Plast Reconstr Surg 62:185-196, 1978
22. Soppimath K, Aminabhavi T, Kulkami A, Rudzinzki W: Biodegradable polymericnanoparticles as drug delivery devices. J Control Release 70:1-20, 2001
23. Vinnik CA: Spherical contracture of fibrous capsules around breast implants: Prevention and treatment. Plast Reconstr Surg 58:555-560, 1976
24. Wilkerson M, Fulcher S, Shields MB, Foulks GN, Hatchell DL, Houston LL: Inhibition of human subconjunctival fibroblast proliferation by immunotoxin. Invest Ophthalmol Vis Sci 33:2293-2298, 1992
25. Yamamoto T, Varani J, Soong HK, Lichter PR: Effects of 5-fluorouracil and mitomycin C on cultured rabbit subconjunctival fibroblasts. Ophthalmology 97:1204-1210, 1990