Nutritional effects of γ-glutamyl carboxylase gene polymorphism on the correlation between the vitamin K status and γ-carboxylation of osteocalcin in young males

Journal of Nutritional Science and Vitaminology

Volumn 53, Issue 5, 2007, Pages 419-425

  Sogabe, Natsuko ^a   Tsugawa, Naoko ^b   Maruyama, Rieko ^a   Kamao, Maya ^b   Kinoshita, Hiroyuki ^c   Okano, Toshio ^b   Hosoi, Takayuki ^d   Goseki Sone, Masae ^a  

^a JAPAN WOMEN'S UNIVERSITY   (Japan)

^b KOBE PHARMACEUTICAL UNIVERSITY   (Japan)

^c UNIVERSITY OF TOKYO   (Japan)

^d NATIONAL CENTER FOR GERIATRICS AND GERONTOLOGY   (Japan)

Author keywords

glutamyl carboxylase; Menaquinone 7 (MK 7); Phylloquinone (PK); Single nucleotide polymorphisms; Vitamin K intake

Indexed keywords

MENAQUINONE; OSTEOCALCIN; PHYTOMENADIONE; VITAMIN K DEPENDENT CARBOXYLASE;

ADULT; ARTICLE; BEAN; BLOOD ANALYSIS; CARBOXYLATION; GENETIC ASSOCIATION; GENETIC CORRELATION; GENETIC POLYMORPHISM; GENOTYPE; HETEROZYGOSITY; HOMOZYGOTE; HUMAN; MALE; NORMAL HUMAN; NUTRIENT LOADING; NUTRITIONAL ASSESSMENT; NUTRITIONAL HEALTH; SINGLE NUCLEOTIDE POLYMORPHISM; VITAMIN BLOOD LEVEL; VITAMIN INTAKE; VOLUNTEER;

ADULT; BIOLOGICAL MARKERS; CALCIUM; CARBON-CARBON LIGASES; CHROMATOGRAPHY, LIQUID; DIET RECORDS; GENOTYPE; HUMANS; MALE; NUTRITION PHYSIOLOGY; NUTRITIONAL STATUS; OSTEOCALCIN; POLYMORPHISM, GENETIC; REFERENCE VALUES; TANDEM MASS SPECTROMETRY; VITAMIN K;

EID: 36349002288     PISSN: 03014800     EISSN: 18817742     Source Type: Journal    
DOI: 10.3177/jnsv.53.419     Document Type: Article

References (41)

1. NIH Consensus Development Panel on Osteoporosis Prevention, Diagnosis, and Therapy. 2001. Osteoporosis prevention, diagnosis, and therapy. JAMA 285: 785-795.
2. Kaneki M, Hosoi T, Ouchi Y, Orimo H. 2006. Pleiotropic actions of vitamin K: protector of bone health and beyond? Nutrition 22: 845-852.
3. Berkner KL, Pudota BN. 1998. Vitamin K-dependent carboxylation of the carboxylase. Proc Natl Acad Sci USA 95: 466-471.
4. Furie B, Bouchard BA, Furie BC. 1999. Vitamin K-dependent biosynthesis of γ-carboxyglutamic acid. Blood 93: 1798-1808.
5. Stanley TB, Jin DY, Lin PJ, Stafford DW. 1999. The propeptides of the vitamin K-dependent proteins possess different affinities for the vitamin K-dependent carboxylase. J Biol Chem 274: 16940-16944.
6. Knobloch JE, Suttie JW. 1987. Vitamin K-dependent carboxylase. Control of enzyme activity by the "propeptide" region of factor X. J Biol Chem 262: 15334-15337.
7. Berkner KL. 2000. The vitamin K-dependent carboxylase. J Nutr 130: 1877-1880.
8. Shearer MJ. 1997. The roles of vitamins D and K in bone health and osteoporosis prevention. Proc Nutr Soc 56: 915-937.
9. Binkley NC, Suttie JW. 1995. Vitamin K nutrition and osteoporosis. J Nutr 125: 1812-1821.
10. Weber P. 1997. Management of osteoporosis: is there a role for vitamin K? Int J Vitam Nutr Res 67: 350-356.
11. Price PA. 1988. Role of vitamin K-dependent proteins in bone metabolism. Annu Rev Nutr 8: 565-583.
12. Sokoll LJ, Booth SL, O'Brien ME, Davidson KW, Tsaioun KI, Sadowski JA. 1997. Changes in serum osteocalcin, plasma phylloquinone, and urinary gamma-carboxyglutamic acid in response to altered intakes of dietary phylloquinone in human subjects. Am J Clin Nutr 65: 779-784.
13. Binkley NC, Krueger DC, Engelke JA, Foley AL, Suttie JW. 2000. Vitamin K supplementation reduces serum concentrations of under-γ-carboxylated osteocalcin in healthy young and elderly adults. Am J Clin Nutr 72: 1523-1528.
14. McKeown NM, Jacques PF, Gundberg CM, Peterson JW, Tucker KL, Kiel DP, Wilson PW, Booth SL. 2002. Dietary and nondietary determinants of vitamin K biochemical measures in men and women. J Nutr 132: 1329-1334.
15. Binkley NC, Krueger DC, Kawahara TN, Engelke JA, Chappell RJ, Suttie JW. 2002. A high phylloquinone intake is required to achieve maximal osteocalcin gamma-carboxylation. Am J Clin Nutr 76: 1055-1060.
16. Szulc P, Chapuy MC, Meunier PJ, Delmas PD. 1993. Serum undercarboxylated osteocalcin is a marker of the risk of hip fracture in elderly women. J Clin Invest 91: 1769-1774.
17. Vergnaud P, Garnero P, Meunier PJ, Breart G, Kamihagi K, Delmas PD. 1997. Undercarboxylated osteocalcin measured with a specific immunoassay predicts hip fracture in elderly women: the EPIDOS Study. J Clin Endocrinol Metab 82: 719-724.
18. Kohlmeier M, Saupe J, Shearer MJ, Schaefer K, Asmus G. 1997. Bone health of adult hemodialysis patients is related to vitamin K status. Kidney Int 51: 1218-1221.
19. Booth SL, Tucker KL, Chen H, Hannan MT, Gagnon DR, Cupples LA, Wilson PW, Ordovas J, Schaefer EJ, Dawson-Hughes B, Kiel DP. 2000. Dietary vitamin K intakes are associated with hip fracture but not with bone mineral density in elderly men and women. Am J Clin Nutr 71: 1201-1208.
20. Booth SL, Suttie JW. 1998. Dietary intake and adequacy of vitamin K. J Nutr 128: 785-788.
21. Ikeda H, Doi Y. 1990. A vitamin-K2-binding factor secreted from Bacillus subtilis. Eur J Biochem 192: 219-224.
22. Kaneki M, Hodges SJ, Hosoi T, Fujiwara S, Lyons A, Crean SJ, Ishida N, Nakagawa M, Takechi M, Sano Y, Mizuno Y, Hoshino S, Miyao M, Inoue S, Horiki K, Shiraki M, Ouchi Y, Orimo H. 2001. Japanese fermented soybean food as the major determinant of the large geographic difference in circulating levels of vitamin K2: possible implications for hip-fracture risk. Nutrition 17: 315-321.
23. Kinoshita H, Nakagawa K, Narusawa K, Goseki-Sone M, Fukushi-Irie M, Mizoi L, Yoshida H, Okano T, Nakamura T, Suzuki T, Inoue S, Orimo H, Ouchi Y, Hosoi T. 2007. A functional single nucleotide polymorphism in the vitamin-K-dependent gamma-glutamyl carboxylase gene (Arg325Gln) is associated with bone mineral density in elderly Japanese women. Bone 40: 451-456.
24. Kobayashi S, Inoue S, Hosoi T, Ouchi Y, Shiraki M, Orimo H. 1996. Association of bone mineral density with polymorphism of the estrogen receptor gene. J Bone Miner Res 11: 306-311.
25. Shiraki M, Shiraki Y, Aoki C, Hosoi T, Inoue S, Kaneki M, Ouchi Y. 1997. Association of bone mineral density with apolipoprotein E phenotype. J Bone Miner Res 12: 1438-1445.
26. Hosoi T, Miyao M, Inoue S, Hoshino S, Shiraki M, Orimo H, Ouchi Y. 1999. Association study of parathyroid hormone gene polymorphism and bone mineral density in Japanese postmenopausal women. Calcif Tissue Int 64: 205-208.
27. Miyao M, Hosoi T, Inoue S, Hoshino S, Shiraki M, Orimo H, Ouchi Y. 1998. Polymorphism of insulin-like growth factor I gene and bone mineral density. Calcif Tissue Int 63: 306-311.
28. Yamada Y, Harada A, Hosoi T, Miyauchi A, Ikeda K, Ohta H, Shiraki M. 2000. Association of transforming growth factor betal genotype with therapeutic response to active vitamin D for postmenopausal osteoporosis. J Bone Miner Res 15: 415-420.
29. Ogawa S, Hosoi T, Shiraki M, Orimo H, Emi M, Muramatsu M, Ouchi Y, Inoue S. 2000. Association of estrogen receptor beta gene polymorphism with bone mineral density. Biochem Biophys Res Commun 269: 537-541.
30. Miyao M, Morita H, Hosoi T, Kurihara H, Inoue S, Hoshino S, Shiraki M, Yazaki Y, Ouchi Y. 2000. Association of methylenetetrahydrofolate reductase (MTHFR) polymorphism with bone mineral density in postmenopausal Japanese women. Calcif Tissue Int 66: 190-194.
31. Kawano K, Ogata N, Chiano M, Molloy H, Kleyn P, Spector TD, Uchida M, Hosoi T, Suzuki T, Orimo H, Inoue S, Nabeshima Y, Nakamura K, Kuro-o M, Kawaguchi H. 2002. Klotho gene polymorphisms associated with bone density of aged postmenopausal women. J Bone Miner Res 17: 1744-1751.
32. Goseki-Sone M, Sogabe N, Fukushi-Irie M, Mizoi L, Orimo H, Suzuki T, Nakamura H, Orimo H, Hosoi T. 2005. Functional analysis of the single nucleotide polymorphism (787T>C) in the tissue-nonspecific alkaline phosphatase gene associated with BMD. J Bone Miner Res 20: 773-782.
33. Suhara Y, Kamao M, Tsugawa N, Okano T. 2005. Method for the determination of vitamin K homologues in human plasma using high-performance liquid chromatography-tandem mass spectrometry. Anal Chem 77: 757-763.
34. Tsugawa N, Shiraki M, Suhara Y, Kamao M, Tanaka K, Okano T. 2006. Vitamin K status of healthy Japanese women: age-related vitamin K requirement for gamma-carboxylation of osteocalcin. Am J Clin Nutr 83: 380-386.
35. Booth SL, Sokoll LJ, O'Brien ME, Tucker K, Dawson-Hughes B, Sadowski JA. 1995. Assessment of dietary phylloquinone intake and vitamin K status in post-menopausal women. Eur J Clin Nutr 49: 832-841.
36. Booth SL, Lichtenstein AH, Dallai GE. 2002. Phylloquinone absorption from phylloquinone-fortified oil is greater than from a vegetable in younger and older men and women. J Nutr 132: 2609-2612.
37. Shiraki M, Shiraki Y, Aoki C, Miura M. 2000. Vitamin K2 (menatetrenone) effectively prevents fractures and sustains lumbar bone mineral density in osteoporosis. J Bone Miner Res 15: 515-521.
38. Wu SM, Cheung WF, Frazier D, Stafford DW. 1991. Cloning and expression of the cDNA for human gamma-glutamyl carboxylase. Science 254: 1634-1636.
39. Kuo WL, Stafford DW, Cruces J, Gray J, Solera J. 1995. Chromosomal localization of the gamma-glutamyl carboxylase gene at 2p12. Genomics 25: 746-748.
40. Wu SM, Stafford DW, Frazier LD, Fu YY, High KA, Chu K, Sanchez-Vega B, Solera J. 1997. Genomic sequence and transcription start site for the human gamma-glutamyl carboxylase. Blood 89: 4058-4062.
41. Brenner B, Sánchez-Vega B, Wu SM, Lanir N, Stafford DW, Solera J. 1998. A missense mutation in a gamma-glutamyl carboxylase gene causes combined deficiency of all vitamin K-dependent blood coagulation factors. Blood 92: 4554-4559.