CC10 reduces inflammation in meconium aspiration syndrome in newborn piglets

Pediatric Research

Volumn 62, Issue 6, 2007, Pages 684-688

  Angert, Robert M ^a   Pilon, Aprile L ^b   Chester, Darrin ^a   Davis, Jonathan M ^c  

^a WINTHROP UNIVERSITY HOSPITAL   (United States)

^b Claragen Inc   (United States)

^c TUFTS MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CLARA CELL PROTEIN; INTERLEUKIN 8; PHOSPHOLIPASE A2; SODIUM CHLORIDE; SURFACTANT; TUMOR NECROSIS FACTOR ALPHA;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; ASPIRATION; COMPARATIVE STUDY; CONTROLLED STUDY; ENZYME ACTIVITY; HISTOLOGY; INFLAMMATORY INFILTRATE; LUNG ALVEOLUS WALL; LUNG FUNCTION; MECONIUM; MECONIUM ASPIRATION; NEWBORN; NONHUMAN; PHYSIOLOGY; PIGLET; PNEUMONIA; PRIORITY JOURNAL; STATISTICAL SIGNIFICANCE; TRACHEA;

ANIMALS; ANIMALS, NEWBORN; ANTI-INFLAMMATORY AGENTS; BRONCHOALVEOLAR LAVAGE FLUID; DISEASE MODELS, ANIMAL; DRUG THERAPY, COMBINATION; ENZYME INHIBITORS; HUMANS; INFANT, NEWBORN; INTERLEUKIN-8; LUNG; MECONIUM; MECONIUM ASPIRATION SYNDROME; PHOSPHOLIPASES A2, SECRETORY; PULMONARY SURFACTANTS; RECOMBINANT PROTEINS; SWINE; TIME FACTORS; TUMOR NECROSIS FACTOR-ALPHA; UTEROGLOBIN;

EID: 36348990750     PISSN: 00313998     EISSN: None     Source Type: Journal    
DOI: 10.1203/PDR.0b013e31815a5632     Document Type: Article

References (28)

1. Yoder BA, Kirsch EA, Barth WH, Gordon MC 2002 Changing obstetric practices associated with decreasing incidence of meconium aspiration syndrome. Obstet Gynecol 99:731-739
2. Tyler DC, Murphy J, Cheney FW 1978 Mechanical and chemical damage to lung tissue caused by meconium aspiration. Pediatrics 62:454-459
3. Holopainen R, Aho H, Laine J, Peuravuori H, Soukka H, Kaapa P 1999 Human meconium has high phospholipase A2 activity and induces cellular injury and apoptosis in piglet lungs. Pediatr Res 46:626-632
4. Yao XL, Levine SJ, Cowan MJ, Logun C, Shelhamer JH 1998 Tumor necrosis factor-alpha stimulates human Clara cell secretory protein production by human airway epithelial cells. Am J Respir Cell Mol Biol 19:629-635
5. Ward M, Sinn J 2003 Steroid therapy for meconium aspiration syndrome in newborn infants. Cochrane Database Syst Rev CD003485
6. Levin SW, Butler JD, Schumacher UK, Wightman PD, Mukherjee AB 1986 Uteroglobin inhibits phospholipase A2 activity. Life Sci 38:1813-1819
7. Pilon AL 2000 Rationale for the development of recombinant human CC10 as a therapeutic for inflammatory and fibrotic disease. Ann N Y Acad Sci 923:280-299
8. Zhang Z, Kundu GC, Yuan CJ, Ward JM, Lee EJ, DeMayo F, Westphal H, Mukherjee AB 1997 Severe fibronectin-deposit renal glomerular disease in mice lacking uteroglobin. Science 276:1408-1412
9. Johnston CJ, Mango GW, Finkelstein JN, Stripp BR 1997 Altered pulmonary response to hyperoxia in Clara cell secretory protein deficient mice. Am J Respir Cell Mol Biol 17:147-155
10. Miller TL, Shashikant BN, Melby JM, Pilon AL, Shaffer TH, Wolfson MR 2005 Recombinant human Clara cell secretory protein in acute lung injury of the rabbit: effect of route of administration. Pediatr Crit Care Med 6:698-706
11. Nosratabadi AR, Ljungman AG, Lindahl M, Welch R, Pilon A, Tagesson C 2003 Clara cell 10-KDA protein inhibits endotoxin-induced airway contraction in isolated perfused rat lungs. Exp Lung Res 29:455-473
12. Wang SZ, Rosenberger CL, Bao YX, Stark JM, Harrod KS 2003 Clara cell secretory protein modulates lung inflammatory and immune responses to respiratory syncytial virus infection. J Immunol 171:1051-1060
13. Levine CR, Gewolb IH, Allen K, Welch RW, Melby JM, Pollack S, Shaffer T, Pilon AL, Davis JM 2005 The safety, pharmacokinetics, and anti-inflammatory effects of intratracheal recombinant human Clara cell protein in premature infants with respiratory distress syndrome. Pediatr Res 58:15-21
14. Davey AM, Becker JD, Davis JM 1993 Meconium aspiration syndrome: physiological and inflammatory changes in a newborn piglet model. Pediatr Pulmonol 16:101-108
15. Chandra S, Davis JM, Drexler S, Kowalewska J, Chester D, Koo HC, Pollack S, Welch R, Pilon A, Levine CR 2003 Safety and efficacy of intratracheal recombinant human Clara cell protein in a newborn piglet model of acute lung injury. Pediatr Res 54:509-515
16. Smith PK, Krohn RI, Hermanson GT, Mallia AK, Gartner FH, Provenzano MD, Fujimoto EK, Goeke NM, Olson BJ, Klenk DC 1985 Measurement of protein using bicinchoninic acid. Anal Biochem 150:76-85
17. Vassalli P 1992 The pathophysiology of tumor necrosis factors. Annu Rev Immunol 10:411-452
18. Berdeli A, Akisu M, Dagci T, Akisu C, Yalaz M, Kultursay N 2004 Meconium enhances platelet-activating factor and tumor necrosis factor production by rat alveolar macrophages. Prostaglandins Leukot Essent Fatty Acids 71:227-232
19. Bernard A, Thielemans N, Lauwerys R, Langhendries JP, Van Lierde M, Freund MM 1994 Clara cell protein in human amniotic fluid: a potential marker of fetal lung growth. Pediatr Res 36:771-775
20. Mantile G, Miele L, Cordella-Miele E, Singh G, Katyal SL, Mukherjee AB 1993 Human Clara cell 10-kDa protein is the counterpart of rabbit uteroglobin. J Biol Chem 268:20343-20351
21. de Beaufort AJ, Pelikan DM, Elferink JG, Berger HM 1998 Effect of interleukin 8 in meconium on in-vitro neutrophil chemotaxis. Lancet 352:102-105
22. Korhonen K, Soukka H, Halkola L, Peuravuori H, Aho H, Pulkki K, Kero P, Kaapa PO 2003 Meconium induces only localized inflammatory lung injury in piglets. Pediatr Res 54:192-197
23. Jo EJ, Lee HY, Lee YN, Kim JI, Kang HK, Park DW, Baek SH, Kwak JY, Bae YS 2004 Group IB secretory phospholipase A2 stimulates CXC chemokine ligand 8 production via ERK and NF-kappa B in human neutrophils. J Immunol 173:6433-6439
24. Granata F, Petraroli A, Boilard E, Bezzine S, Bollinger J, Del Vecchio L, Gelb MH, Lambeau G, Marone G, Triggiani M 2005 Activation of cytokine production by secreted phospholipase A2 in human lung macrophages expressing the M-type receptor. J Immunol 174:464-474
25. Talati AJ, Crouse DT, English BK, Newman C, Livingston L, Meals E 1998 Exogenous bovine surfactant suppresses tumor necrosis factor-alpha release by murine macrophages stimulated by genital mycoplasmas. J Infect Dis 178:1122-1125
26. Janssen DJ, Tibboel D, Carnielli VP, van Emmen E, Luijendijk IH, Darcos Wattimena JL, Zimmermann LJ 2003 Surfactant phosphatidylcholine pool size in human neonates with congenital diaphragmatic hernia requiring ECMO. J Pediatr 142:247-252
27. Halbertsma FJ, Vaneker M, Scheffer GJ, van der Hoeven JG 2005 Cytokines and biotrauma in ventilator-induced lung injury: a critical review of the literature. Neth J Med 63:382-392
28. Vaillant P, Menard O, Vignaud JM, Martinet N, Martinet Y 1996 The role of cytokines in human lung fibrosis. Monaldi Arch Chest Dis 51:145-152